The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis
Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-02-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/12/2/428 |
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| author | Ljiljana Krsmanović Nenad Arsović Dejan Bokonjić Vladimir Nešić Zoran Dudvarski Dragana Pavlović Milena Dubravac Tanasković Siniša Ristić Nikolina Elez-Burnjaković Radmila Balaban Branislava Ćurčić Radenko Ivanović Nikolina Vuković Maja Vuković Marija Milić Bojan Joksimović |
| author_facet | Ljiljana Krsmanović Nenad Arsović Dejan Bokonjić Vladimir Nešić Zoran Dudvarski Dragana Pavlović Milena Dubravac Tanasković Siniša Ristić Nikolina Elez-Burnjaković Radmila Balaban Branislava Ćurčić Radenko Ivanović Nikolina Vuković Maja Vuković Marija Milić Bojan Joksimović |
| author_sort | Ljiljana Krsmanović |
| collection | DOAJ |
| description | Background: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR. Methods: European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), “The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire” (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay. Results: The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; <i>p</i> < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; <i>p</i> < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β (<i>p</i> = 0.002), IL-6 (<i>p</i> = 0.031), IL-8 (<i>p</i> < 0.001), IL17-A (<i>p</i> = 0.013) and IL-18 (<i>p</i> = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly (<i>p</i> < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR. Conclusions: This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research. |
| first_indexed | 2024-03-07T22:41:06Z |
| format | Article |
| id | doaj.art-dfece35db89c400285352cdf343977f8 |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-07T22:41:06Z |
| publishDate | 2024-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-dfece35db89c400285352cdf343977f82024-02-23T15:08:48ZengMDPI AGBiomedicines2227-90592024-02-0112242810.3390/biomedicines12020428The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic RhinitisLjiljana Krsmanović0Nenad Arsović1Dejan Bokonjić2Vladimir Nešić3Zoran Dudvarski4Dragana Pavlović5Milena Dubravac Tanasković6Siniša Ristić7Nikolina Elez-Burnjaković8Radmila Balaban9Branislava Ćurčić10Radenko Ivanović11Nikolina Vuković12Maja Vuković13Marija Milić14Bojan Joksimović15University Hospital Foča, 73300 Foča, Bosnia and HerzegovinaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaUniversity Hospital Foča, 73300 Foča, Bosnia and HerzegovinaClinic of Otorhinolaryngology and Maxillofacial Surgery, Clinical Center of Serbia, 11000 Belgrade, SerbiaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaUniversity Hospital Foča, 73300 Foča, Bosnia and HerzegovinaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaUniversity Hospital Foča, 73300 Foča, Bosnia and HerzegovinaUniversity Hospital Foča, 73300 Foča, Bosnia and HerzegovinaUniversity Hospital Foča, 73300 Foča, Bosnia and HerzegovinaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaDepartment of Epidemiology, Faculty of Medicine, University of Pristina Temporarily Seated in Kosovska Mitrovica, 38220 Kosovska Mitrovica, SerbiaFaculty of Medicine Foča, University of East Sarajevo, 73300 Foča, Bosnia and HerzegovinaBackground: Frequent episodes of nasal symptoms are the usual clinical manifestations (CM) of allergic rhinitis (AR) and have a significant negative impact on health-related quality of life (HRQoL) in adolescents. The purpose of this cross-sectional study was to test the hypothesis that cytokines in nasal mucus may be associated with HRQoL in adolescents with AR. Methods: European Quality of Life 5 Dimensions 3 Level Version (EQ-5D-3L), “The Adolescent Rhinoconjunctivitis Quality of Life Questionnaire” (AdolRQLQ) and the Total 4 Symptom Score (T4SS) scoring system were administered to 113 adolescents with AR, nonallergic rhinitis (NAR) and to healthy control subjects. Nasal secretions were sampled and tested for 13 cytokines using a multiplex flow cytometric bead assay. Results: The AR group had significantly lower EQ-5D-3L (0.661 ± 0.267 vs. 0.943 ± 0.088; <i>p</i> < 0.001) and higher AdolRQLQ total scores (2.76 ± 1.01 vs. 1.02 ± 0.10; <i>p</i> < 0.001) compared to the control group. The AR group had higher concentrations of IL-1β (<i>p</i> = 0.002), IL-6 (<i>p</i> = 0.031), IL-8 (<i>p</i> < 0.001), IL17-A (<i>p</i> = 0.013) and IL-18 (<i>p</i> = 0.014) compared to the control group, and IL-1β, IL-6, IL17-A and IL-18 were significantly (<i>p</i> < 0.050) increased with disease progression. Cytokines IL-1β, IL-6, as well as severe CM, were identified as significant predictors of lower HRQoL in adolescents with AR. Conclusions: This study identified IL-1β, IL-6, as well as severe CM, as predictors of lower HRQoL in adolescents with AR. However, these results should only serve as a starting point for additional confirmation research.https://www.mdpi.com/2227-9059/12/2/428allergic rhinitiscytokineshealth-related quality of lifeadolescents |
| spellingShingle | Ljiljana Krsmanović Nenad Arsović Dejan Bokonjić Vladimir Nešić Zoran Dudvarski Dragana Pavlović Milena Dubravac Tanasković Siniša Ristić Nikolina Elez-Burnjaković Radmila Balaban Branislava Ćurčić Radenko Ivanović Nikolina Vuković Maja Vuković Marija Milić Bojan Joksimović The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis Biomedicines allergic rhinitis cytokines health-related quality of life adolescents |
| title | The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis |
| title_full | The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis |
| title_fullStr | The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis |
| title_full_unstemmed | The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis |
| title_short | The Impact of Cytokines on Health-Related Quality of Life in Adolescents with Allergic Rhinitis |
| title_sort | impact of cytokines on health related quality of life in adolescents with allergic rhinitis |
| topic | allergic rhinitis cytokines health-related quality of life adolescents |
| url | https://www.mdpi.com/2227-9059/12/2/428 |
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