Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives
A series of N-acetyl pyrazole derivatives, 1-acetyl-3-aryl-5-[5'-(4-nitrophenyl)-2'-furyl]-4,5-dihydro-1H-pyrazoles (5a-j) were synthesized by cyclocondensation reaction between 1-aryl-3-[5-(4-nitrophenyl)-2-furyl]prop-2-en-1-ones (4a-j) and hydrazine hydrate in glacial acetic aci...
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| Format: | Article |
| Language: | English |
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Growing Science
2022-01-01
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| Series: | Current Chemistry Letters |
| Online Access: | http://www.growingscience.com/ccl/Vol11/ccl_2022_2.pdf |
| _version_ | 1818487632813883392 |
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| author | M. F. Dhaduk H. S. Joshi |
| author_facet | M. F. Dhaduk H. S. Joshi |
| author_sort | M. F. Dhaduk |
| collection | DOAJ |
| description | A series of N-acetyl pyrazole derivatives, 1-acetyl-3-aryl-5-[5'-(4-nitrophenyl)-2'-furyl]-4,5-dihydro-1H-pyrazoles (5a-j) were synthesized by cyclocondensation reaction between 1-aryl-3-[5-(4-nitrophenyl)-2-furyl]prop-2-en-1-ones (4a-j) and hydrazine hydrate in glacial acetic acid at reflux temperature. Before that, compounds (4a-j) were synthesized by the condensation of 5-(4-nitrophenyl) furan-2-carbaldehyde (3) with various aromatic ketones by using alkali as catalyst. The constitution of the synthesized products has been characterized by using elemental analysis, Infrared,1H-NMR, 13C-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their in-vitro biological assay like antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40 µg/ml. It was exposed that the compounds 5a, 5b, 5c, 5d, 5g, 5h and 5j showed motivating antibacterial and antifungal activity compared to the used reference standard. |
| first_indexed | 2024-12-10T16:40:43Z |
| format | Article |
| id | doaj.art-dfecf18dd8234580a46a88829196d832 |
| institution | Directory Open Access Journal |
| issn | 1927-7296 1927-730X |
| language | English |
| last_indexed | 2024-12-10T16:40:43Z |
| publishDate | 2022-01-01 |
| publisher | Growing Science |
| record_format | Article |
| series | Current Chemistry Letters |
| spelling | doaj.art-dfecf18dd8234580a46a88829196d8322022-12-22T01:41:14ZengGrowing ScienceCurrent Chemistry Letters1927-72961927-730X2022-01-0111219920610.5267/j.ccl.2022.1.002Synthesis, characterization and biological study of some new N-acetyl pyrazole derivativesM. F. DhadukH. S. Joshi A series of N-acetyl pyrazole derivatives, 1-acetyl-3-aryl-5-[5'-(4-nitrophenyl)-2'-furyl]-4,5-dihydro-1H-pyrazoles (5a-j) were synthesized by cyclocondensation reaction between 1-aryl-3-[5-(4-nitrophenyl)-2-furyl]prop-2-en-1-ones (4a-j) and hydrazine hydrate in glacial acetic acid at reflux temperature. Before that, compounds (4a-j) were synthesized by the condensation of 5-(4-nitrophenyl) furan-2-carbaldehyde (3) with various aromatic ketones by using alkali as catalyst. The constitution of the synthesized products has been characterized by using elemental analysis, Infrared,1H-NMR, 13C-NMR spectroscopy and further supported by Mass spectroscopy. All the products have been screened for their in-vitro biological assay like antibacterial activity towards Gram-positive and Gram-negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40 µg/ml. It was exposed that the compounds 5a, 5b, 5c, 5d, 5g, 5h and 5j showed motivating antibacterial and antifungal activity compared to the used reference standard.http://www.growingscience.com/ccl/Vol11/ccl_2022_2.pdf |
| spellingShingle | M. F. Dhaduk H. S. Joshi Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives Current Chemistry Letters |
| title | Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives |
| title_full | Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives |
| title_fullStr | Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives |
| title_full_unstemmed | Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives |
| title_short | Synthesis, characterization and biological study of some new N-acetyl pyrazole derivatives |
| title_sort | synthesis characterization and biological study of some new n acetyl pyrazole derivatives |
| url | http://www.growingscience.com/ccl/Vol11/ccl_2022_2.pdf |
| work_keys_str_mv | AT mfdhaduk synthesischaracterizationandbiologicalstudyofsomenewnacetylpyrazolederivatives AT hsjoshi synthesischaracterizationandbiologicalstudyofsomenewnacetylpyrazolederivatives |