Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children
Background: The prevalence of maternal oral contraceptive pills (OCP) use and that of childhood asthma are high in western countries. The aim of this study is to examine the association of OCP use with childhood wheeze and allergic diseases in Japan. Methods: Relevant data were extracted from a hosp...
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| Format: | Article |
| Language: | English |
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Elsevier
2016-07-01
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| Series: | Allergology International |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1323893016300065 |
| _version_ | 1818672172249382912 |
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| author | Kiwako Yamamoto-Hanada Masaki Futamura Limin Yang Tetsuo Shoda Masami Narita Fumio Kobayashi Hirohisa Saito Yukihiro Ohya |
| author_facet | Kiwako Yamamoto-Hanada Masaki Futamura Limin Yang Tetsuo Shoda Masami Narita Fumio Kobayashi Hirohisa Saito Yukihiro Ohya |
| author_sort | Kiwako Yamamoto-Hanada |
| collection | DOAJ |
| description | Background: The prevalence of maternal oral contraceptive pills (OCP) use and that of childhood asthma are high in western countries. The aim of this study is to examine the association of OCP use with childhood wheeze and allergic diseases in Japan.
Methods: Relevant data were extracted from a hospital based birth cohort study named as Tokyo-Children's Health, Illness and Development Study (T-CHILD) of which questionnaire conducted during pregnancy included maternal history and duration of OCP use. To identify wheeze and allergic diseases in the children, the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC) was used. Logistic regression models were applied to estimate those association and adjustments were made for maternal history of allergy, maternal education level, maternal age at pregnancy, maternal BMI, maternal smoking during pregnancy, mode of delivery, gestational age at delivery, daycare attendance, number of previous live births, and gender of child.
Results: OCP use was associated with ever wheeze (adjusted odds ratio [aOR], 1.62; 95% confidence interval [CI], 1.10–2.40), current wheeze (aOR, 1.59; 95% CI, 1.01–2.50), ever asthma (aOR, 1.65; 95% CI, 1.02–2.65), and ever rhinitis (aOR, 1.90; 95% CI, 1.30–2.80). Compared with no prior OCP use, using OCP for more than three months statistically increased the odds of ever wheeze (P = 0.012), current wheeze (P = 0.035), and ever rhinitis (P = 0.002).
Conclusions: Our findings suggest that maternal OCP use has a role in the development of wheeze, asthma and rhinitis in children. Extended use of OCP is likely to increase the risk of wheeze and rhinitis. |
| first_indexed | 2024-12-17T07:35:40Z |
| format | Article |
| id | doaj.art-dfed6dfe760a4c749380db7d3ff25d1d |
| institution | Directory Open Access Journal |
| issn | 1323-8930 |
| language | English |
| last_indexed | 2024-12-17T07:35:40Z |
| publishDate | 2016-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Allergology International |
| spelling | doaj.art-dfed6dfe760a4c749380db7d3ff25d1d2022-12-21T21:58:21ZengElsevierAllergology International1323-89302016-07-0165332733110.1016/j.alit.2016.02.012Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in childrenKiwako Yamamoto-Hanada0Masaki Futamura1Limin Yang2Tetsuo Shoda3Masami Narita4Fumio Kobayashi5Hirohisa Saito6Yukihiro Ohya7Division of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanDivision of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanDivision of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanDivision of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanDivision of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanDepartment of Health and Psychosocial Medicine, Aichi Medical University School of Medicine, Aichi, JapanDepartment of Allergy and Immunology, National Research Institute for Child Health and Development, Tokyo, JapanDivision of Allergy, Department of Medical Subspecialties, National Center for Child Health and Development, Tokyo, JapanBackground: The prevalence of maternal oral contraceptive pills (OCP) use and that of childhood asthma are high in western countries. The aim of this study is to examine the association of OCP use with childhood wheeze and allergic diseases in Japan. Methods: Relevant data were extracted from a hospital based birth cohort study named as Tokyo-Children's Health, Illness and Development Study (T-CHILD) of which questionnaire conducted during pregnancy included maternal history and duration of OCP use. To identify wheeze and allergic diseases in the children, the questionnaire of the International Study of Asthma and Allergies in Childhood (ISAAC) was used. Logistic regression models were applied to estimate those association and adjustments were made for maternal history of allergy, maternal education level, maternal age at pregnancy, maternal BMI, maternal smoking during pregnancy, mode of delivery, gestational age at delivery, daycare attendance, number of previous live births, and gender of child. Results: OCP use was associated with ever wheeze (adjusted odds ratio [aOR], 1.62; 95% confidence interval [CI], 1.10–2.40), current wheeze (aOR, 1.59; 95% CI, 1.01–2.50), ever asthma (aOR, 1.65; 95% CI, 1.02–2.65), and ever rhinitis (aOR, 1.90; 95% CI, 1.30–2.80). Compared with no prior OCP use, using OCP for more than three months statistically increased the odds of ever wheeze (P = 0.012), current wheeze (P = 0.035), and ever rhinitis (P = 0.002). Conclusions: Our findings suggest that maternal OCP use has a role in the development of wheeze, asthma and rhinitis in children. Extended use of OCP is likely to increase the risk of wheeze and rhinitis.http://www.sciencedirect.com/science/article/pii/S1323893016300065AsthmaBirth cohortOral contraceptivesRhinitisWheeze |
| spellingShingle | Kiwako Yamamoto-Hanada Masaki Futamura Limin Yang Tetsuo Shoda Masami Narita Fumio Kobayashi Hirohisa Saito Yukihiro Ohya Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children Allergology International Asthma Birth cohort Oral contraceptives Rhinitis Wheeze |
| title | Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children |
| title_full | Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children |
| title_fullStr | Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children |
| title_full_unstemmed | Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children |
| title_short | Preconceptional exposure to oral contraceptive pills and the risk of wheeze, asthma and rhinitis in children |
| title_sort | preconceptional exposure to oral contraceptive pills and the risk of wheeze asthma and rhinitis in children |
| topic | Asthma Birth cohort Oral contraceptives Rhinitis Wheeze |
| url | http://www.sciencedirect.com/science/article/pii/S1323893016300065 |
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