Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography
Introduction: Our ability to diagnose renal cell carcinoma (RCC) has increased in the past 30 years as a result of the extensive application of imaging techniques, such as ultrasonography, computed tomography, and magnetic resonance imaging. Multi-detector computed tomography (MDCT) remains the mo...
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| Format: | Article |
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Electronic Physician
2016-01-01
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| Series: | Electronic Physician |
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| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768930/ |
| _version_ | 1818540942738587648 |
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| author | Ahmed I Kamel Mohamed H. Badawy Hossam Elganzoury Amr Elkhouly Khalid Elesaily S Eldahshan Mohamed A. A. Ismail Mostafa F Elshafie Emam M Abdel Aziz Ahmed G El Baz Mamdouh A Roshdy Tarek R El Leithy Samir Ghobashy Ahmed M Kamal |
| author_facet | Ahmed I Kamel Mohamed H. Badawy Hossam Elganzoury Amr Elkhouly Khalid Elesaily S Eldahshan Mohamed A. A. Ismail Mostafa F Elshafie Emam M Abdel Aziz Ahmed G El Baz Mamdouh A Roshdy Tarek R El Leithy Samir Ghobashy Ahmed M Kamal |
| author_sort | Ahmed I Kamel |
| collection | DOAJ |
| description | Introduction: Our ability to diagnose renal cell carcinoma (RCC) has increased in the past 30 years as a result of
the extensive application of imaging techniques, such as ultrasonography, computed tomography, and magnetic
resonance imaging. Multi-detector computed tomography (MDCT) remains the most appropriate imaging
modality for the diagnosis and staging of RCC. The aim of this work was to compare the findings of MDCT with
surgical pathology to determine the accuracy of delineating tumor size, localization, organ confinement, lymph
node metastases, and the extent of tumor thrombus in the renal vein and inferior vena cava.
Methods: The clinical, surgical, and anatomo-pathologic records of 99 patients treated by nephrectomy (radical
or partial) for solid renal tumors at Theodor Bilharz Research Institute and Nasser Institute from 2005 to 2011
were reviewed retrospectively. All cases were staged pre-operatively with abdominal MDCT (pre- and post- contrast enhancement) in addition to the routine biochemical, hematological, and radiological work-up. The
tumors’ histologic types were determined according to the WHO classification of renal tumors in adults in 2004,
and staging was updated to the TNM 2010 system. Data were analyzed using the t-test.
Results: The mean age was 52 (range 21-73). Seventy-eight patients were males, and 21 patients were females
(Male/Female ratio: 3.7:1). There were no significant differences in the mean tumor size between radiographic
and pathologic assessments in different tumor stages. The overall incidence of lymph node invasion in surgical
specimens was 76%, whereas MDCT showed a positive incidence in 68.4% of cases (false negative result in 7
cases, 7.6%).
Conclusion: Our findings indicated that MDCT urography is an accurate method to estimate renal tumor size,
lymph node, vascular and visceral metastases preoperatively. Also, preoperative staging of renal tumors with
MDCT represents a valuable and accurate tool. |
| first_indexed | 2024-12-11T22:02:02Z |
| format | Article |
| id | doaj.art-dfed75fc60ac436bbdd73a47842f5d8f |
| institution | Directory Open Access Journal |
| issn | 2008-5842 2008-5842 |
| language | English |
| last_indexed | 2024-12-11T22:02:02Z |
| publishDate | 2016-01-01 |
| publisher | Electronic Physician |
| record_format | Article |
| series | Electronic Physician |
| spelling | doaj.art-dfed75fc60ac436bbdd73a47842f5d8f2022-12-22T00:49:04ZengElectronic PhysicianElectronic Physician2008-58422008-58422016-01-01811791179510.19082/1791Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT UrographyAhmed I KamelMohamed H. BadawyHossam ElganzouryAmr ElkhoulyKhalid ElesailyS EldahshanMohamed A. A. IsmailMostafa F ElshafieEmam M Abdel AzizAhmed G El BazMamdouh A RoshdyTarek R El LeithySamir GhobashyAhmed M KamalIntroduction: Our ability to diagnose renal cell carcinoma (RCC) has increased in the past 30 years as a result of the extensive application of imaging techniques, such as ultrasonography, computed tomography, and magnetic resonance imaging. Multi-detector computed tomography (MDCT) remains the most appropriate imaging modality for the diagnosis and staging of RCC. The aim of this work was to compare the findings of MDCT with surgical pathology to determine the accuracy of delineating tumor size, localization, organ confinement, lymph node metastases, and the extent of tumor thrombus in the renal vein and inferior vena cava. Methods: The clinical, surgical, and anatomo-pathologic records of 99 patients treated by nephrectomy (radical or partial) for solid renal tumors at Theodor Bilharz Research Institute and Nasser Institute from 2005 to 2011 were reviewed retrospectively. All cases were staged pre-operatively with abdominal MDCT (pre- and post- contrast enhancement) in addition to the routine biochemical, hematological, and radiological work-up. The tumors’ histologic types were determined according to the WHO classification of renal tumors in adults in 2004, and staging was updated to the TNM 2010 system. Data were analyzed using the t-test. Results: The mean age was 52 (range 21-73). Seventy-eight patients were males, and 21 patients were females (Male/Female ratio: 3.7:1). There were no significant differences in the mean tumor size between radiographic and pathologic assessments in different tumor stages. The overall incidence of lymph node invasion in surgical specimens was 76%, whereas MDCT showed a positive incidence in 68.4% of cases (false negative result in 7 cases, 7.6%). Conclusion: Our findings indicated that MDCT urography is an accurate method to estimate renal tumor size, lymph node, vascular and visceral metastases preoperatively. Also, preoperative staging of renal tumors with MDCT represents a valuable and accurate tool.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768930/Multi-Detector CT Urographyrenal cell carcinoma |
| spellingShingle | Ahmed I Kamel Mohamed H. Badawy Hossam Elganzoury Amr Elkhouly Khalid Elesaily S Eldahshan Mohamed A. A. Ismail Mostafa F Elshafie Emam M Abdel Aziz Ahmed G El Baz Mamdouh A Roshdy Tarek R El Leithy Samir Ghobashy Ahmed M Kamal Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography Electronic Physician Multi-Detector CT Urography renal cell carcinoma |
| title | Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography |
| title_full | Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography |
| title_fullStr | Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography |
| title_full_unstemmed | Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography |
| title_short | Clinical versus Pathologic staging of Renal Tumors: Role of Multi-Detector CT Urography |
| title_sort | clinical versus pathologic staging of renal tumors role of multi detector ct urography |
| topic | Multi-Detector CT Urography renal cell carcinoma |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4768930/ |
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