Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis
IntroductionNeurodegenerative diseases often cause motor and cognitive deterioration that leads to postural instability and motor impairment, while aging-associated frailty frequently results in reduced muscle mass, balance, and mobility. These conditions increase the risk of falls and injuries in t...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187325/full |
| _version_ | 1797777998118649856 |
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| author | Feifei Feng Feifei Feng Haocheng Xu Yu Sun Xin Zhang Nan Li Xun Sun Xin Tian Renqing Zhao |
| author_facet | Feifei Feng Feifei Feng Haocheng Xu Yu Sun Xin Zhang Nan Li Xun Sun Xin Tian Renqing Zhao |
| author_sort | Feifei Feng |
| collection | DOAJ |
| description | IntroductionNeurodegenerative diseases often cause motor and cognitive deterioration that leads to postural instability and motor impairment, while aging-associated frailty frequently results in reduced muscle mass, balance, and mobility. These conditions increase the risk of falls and injuries in these populations. This study aimed to determine the effects of exercise on falls and consequent injuries among individuals with neurodegenerative diseases and frail aging people.MethodsElectronic database searches were conducted in PubMed, Cochrane Library, SportDiscus, and Web of Science up to 1 January 2023. Randomized controlled trials that reported the effects of exercise on falls and fall-related injuries in neurodegenerative disease and frail aging people were eligible for inclusion. The intervention effects for falls, fractures, and injuries were evaluated by calculating the rate ratio (RaR) or risk ratio (RR) with 95% confidence interval (CI).ResultsSixty-four studies with 13,241 participants met the inclusion criteria. Exercise is effective in reducing falls for frail aging people (RaR, 0.75; 95% CI, 0.68–0.82) and participants with ND (0.53, 0.43–0.65) [dementia (0.64, 0.51–0.82), Parkinson’s disease (0.49, 0.39–0.69), and stroke survivors (0.40, 0.27–0.57)]. Exercise also reduced fall-related injuries in ND patients (RR, 0.66; 95% CI, 0.48–0.90) and decreased fractures (0.63, 0.41–0.95) and fall-related injuries (0.89, 0.84–0.95) among frail aging people. For fall prevention, balance and combined exercise protocols are both effective, and either short-, moderate-, or long-term intervention duration is beneficial. More importantly, exercise only induced a very low injury rate per participant year (0.007%; 95% CI, 0–0.016) and show relatively good compliance with exercise (74.8; 95% CI, 69.7%–79.9%).DiscussionExercise is effective in reducing neurodegenerative disease- and aging-associated falls and consequent injuries, suggesting that exercise is an effective and feasible strategy for the prevention of falls. |
| first_indexed | 2024-03-12T23:12:00Z |
| format | Article |
| id | doaj.art-dfeded80725c4e69948e8c217e3837fa |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T23:12:00Z |
| publishDate | 2023-07-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-dfeded80725c4e69948e8c217e3837fa2023-07-18T03:28:05ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-07-011410.3389/fendo.2023.11873251187325Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysisFeifei Feng0Feifei Feng1Haocheng Xu2Yu Sun3Xin Zhang4Nan Li5Xun Sun6Xin Tian7Renqing Zhao8College of Physical Education, Yangzhou University, Yangzhou, ChinaSchool of Humanities and Education, Guangzhou Nanyang Polytechnic College, Guangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaCollege of Physical Education, Yangzhou University, Yangzhou, ChinaIntroductionNeurodegenerative diseases often cause motor and cognitive deterioration that leads to postural instability and motor impairment, while aging-associated frailty frequently results in reduced muscle mass, balance, and mobility. These conditions increase the risk of falls and injuries in these populations. This study aimed to determine the effects of exercise on falls and consequent injuries among individuals with neurodegenerative diseases and frail aging people.MethodsElectronic database searches were conducted in PubMed, Cochrane Library, SportDiscus, and Web of Science up to 1 January 2023. Randomized controlled trials that reported the effects of exercise on falls and fall-related injuries in neurodegenerative disease and frail aging people were eligible for inclusion. The intervention effects for falls, fractures, and injuries were evaluated by calculating the rate ratio (RaR) or risk ratio (RR) with 95% confidence interval (CI).ResultsSixty-four studies with 13,241 participants met the inclusion criteria. Exercise is effective in reducing falls for frail aging people (RaR, 0.75; 95% CI, 0.68–0.82) and participants with ND (0.53, 0.43–0.65) [dementia (0.64, 0.51–0.82), Parkinson’s disease (0.49, 0.39–0.69), and stroke survivors (0.40, 0.27–0.57)]. Exercise also reduced fall-related injuries in ND patients (RR, 0.66; 95% CI, 0.48–0.90) and decreased fractures (0.63, 0.41–0.95) and fall-related injuries (0.89, 0.84–0.95) among frail aging people. For fall prevention, balance and combined exercise protocols are both effective, and either short-, moderate-, or long-term intervention duration is beneficial. More importantly, exercise only induced a very low injury rate per participant year (0.007%; 95% CI, 0–0.016) and show relatively good compliance with exercise (74.8; 95% CI, 69.7%–79.9%).DiscussionExercise is effective in reducing neurodegenerative disease- and aging-associated falls and consequent injuries, suggesting that exercise is an effective and feasible strategy for the prevention of falls.https://www.frontiersin.org/articles/10.3389/fendo.2023.1187325/fullfallsfall-related injuriesneurodegenerative diseasesagingexercise |
| spellingShingle | Feifei Feng Feifei Feng Haocheng Xu Yu Sun Xin Zhang Nan Li Xun Sun Xin Tian Renqing Zhao Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis Frontiers in Endocrinology falls fall-related injuries neurodegenerative diseases aging exercise |
| title | Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis |
| title_full | Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis |
| title_fullStr | Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis |
| title_full_unstemmed | Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis |
| title_short | Exercise for prevention of falls and fall-related injuries in neurodegenerative diseases and aging-related risk conditions: a meta-analysis |
| title_sort | exercise for prevention of falls and fall related injuries in neurodegenerative diseases and aging related risk conditions a meta analysis |
| topic | falls fall-related injuries neurodegenerative diseases aging exercise |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1187325/full |
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