Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice
Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease (AD). However, the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical e...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2023-12-01
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| Series: | Sports Medicine and Health Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666337623000707 |
| _version_ | 1797388710812057600 |
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| author | Xue Li Yu Jin Xianyi Ding Tongyang Zhu Changling Wei Li Yao |
| author_facet | Xue Li Yu Jin Xianyi Ding Tongyang Zhu Changling Wei Li Yao |
| author_sort | Xue Li |
| collection | DOAJ |
| description | Behavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease (AD). However, the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical evidence. We investigated the potential effect of long-term physical exercise on cognition and hippocampal gene and protein expression changes in a transgenic AD mouse model. Following twenty weeks of treadmill exercise, transgenic AD mice showed improvement in cognitive functions and downregulation of Nod-like receptor protein 3 (NLRP3) (p < 0.01), interleukin-1beta (IL-1β) (p < 0.05), and amyloid-β1-42 (Aβ1-42) (p < 0.05) expression levels. In addition, we observed significant reductions of microglial activation and hippocampal neuronal damage in the exercised AD mice (p < 0.01), which might be a result of the downregulation of NLRP3-mediated signaling and neuro-inflammatory responses. As neuronal damage due to inflammation might be a likely cause of AD-associated cognitive dysfunction. Our results suggested that the anti-inflammatory effects of exercise training involved downregulating the expression of key inflammatory factors and might play an important role in protecting hippocampal neurons against damage during the course of AD. |
| first_indexed | 2024-03-08T22:44:45Z |
| format | Article |
| id | doaj.art-dfee313edd7644ddafca2f7980b063aa |
| institution | Directory Open Access Journal |
| issn | 2666-3376 |
| language | English |
| last_indexed | 2024-03-08T22:44:45Z |
| publishDate | 2023-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Sports Medicine and Health Science |
| spelling | doaj.art-dfee313edd7644ddafca2f7980b063aa2023-12-17T06:41:51ZengKeAi Communications Co., Ltd.Sports Medicine and Health Science2666-33762023-12-0154329335Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 miceXue Li0Yu Jin1Xianyi Ding2Tongyang Zhu3Changling Wei4Li Yao5Corresponding author. School of Sports Medicine and Health, Chengdu Sport University, No. 2 Tiyuan Road, Chengdu, Sichuan, 610041, China.; School of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, ChinaSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, ChinaSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, ChinaSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, ChinaSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, ChinaSchool of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, ChinaBehavioral experiments have demonstrated that long-term physical exercise can be beneficial for learning and memory dysfunction caused by neuroinflammation in Alzheimer's disease (AD). However, the molecular mechanism remains poorly understood due to a lack of sufficient pertinent biochemical evidence. We investigated the potential effect of long-term physical exercise on cognition and hippocampal gene and protein expression changes in a transgenic AD mouse model. Following twenty weeks of treadmill exercise, transgenic AD mice showed improvement in cognitive functions and downregulation of Nod-like receptor protein 3 (NLRP3) (p < 0.01), interleukin-1beta (IL-1β) (p < 0.05), and amyloid-β1-42 (Aβ1-42) (p < 0.05) expression levels. In addition, we observed significant reductions of microglial activation and hippocampal neuronal damage in the exercised AD mice (p < 0.01), which might be a result of the downregulation of NLRP3-mediated signaling and neuro-inflammatory responses. As neuronal damage due to inflammation might be a likely cause of AD-associated cognitive dysfunction. Our results suggested that the anti-inflammatory effects of exercise training involved downregulating the expression of key inflammatory factors and might play an important role in protecting hippocampal neurons against damage during the course of AD.http://www.sciencedirect.com/science/article/pii/S2666337623000707ExerciseNLRP3NeuroinflammationHippocampusAPP/PS1 miceAlzheimer's |
| spellingShingle | Xue Li Yu Jin Xianyi Ding Tongyang Zhu Changling Wei Li Yao Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice Sports Medicine and Health Science Exercise NLRP3 Neuroinflammation Hippocampus APP/PS1 mice Alzheimer's |
| title | Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice |
| title_full | Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice |
| title_fullStr | Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice |
| title_full_unstemmed | Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice |
| title_short | Long-term exercise training inhibits inflammation by suppressing hippocampal NLRP3 in APP/PS1 mice |
| title_sort | long term exercise training inhibits inflammation by suppressing hippocampal nlrp3 in app ps1 mice |
| topic | Exercise NLRP3 Neuroinflammation Hippocampus APP/PS1 mice Alzheimer's |
| url | http://www.sciencedirect.com/science/article/pii/S2666337623000707 |
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