Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer
Objective: The prognostic significance of serum CA19-9 levels in gastric cancer patients remains a matter debate. The aim of this study was to determine the prognostic value of changes in preoperative and postoperative serum CA19-9 levels in patients with gastric cancer.Methods: A total of 1,046 gas...
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| Format: | Article |
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Frontiers Media S.A.
2020-08-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.01432/full |
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| author | Xiao-Hai Song Xiao-Hai Song Kai Liu Kai Liu Shi-Jie Yang Shi-Jie Yang Wei-Han Zhang Wei-Han Zhang Xiao-Long Chen Xiao-Long Chen Lin-Yong Zhao Lin-Yong Zhao Xin-Zu Chen Xin-Zu Chen Kun Yang Kun Yang Zong-Guang Zhou Zong-Guang Zhou Jian-Kun Hu Jian-Kun Hu |
| author_facet | Xiao-Hai Song Xiao-Hai Song Kai Liu Kai Liu Shi-Jie Yang Shi-Jie Yang Wei-Han Zhang Wei-Han Zhang Xiao-Long Chen Xiao-Long Chen Lin-Yong Zhao Lin-Yong Zhao Xin-Zu Chen Xin-Zu Chen Kun Yang Kun Yang Zong-Guang Zhou Zong-Guang Zhou Jian-Kun Hu Jian-Kun Hu |
| author_sort | Xiao-Hai Song |
| collection | DOAJ |
| description | Objective: The prognostic significance of serum CA19-9 levels in gastric cancer patients remains a matter debate. The aim of this study was to determine the prognostic value of changes in preoperative and postoperative serum CA19-9 levels in patients with gastric cancer.Methods: A total of 1,046 gastric cancer patients who underwent curative gastrectomy in West China Hospital of Sichuan University from January 2011 to December 2016 were analyzed retrospectively. Patients were categorized by minimum P-value using X-tile, while the baseline confounders for CA19-9 changes were balanced through propensity score matching (PSM). The relationships between CA19-9 changes and other clinicopathologic features were measured. Univariate and multivariate analysis were performed to explore the risk factors associated with survival outcomes.Results: We included 653 patients. Changes in CA19-9 levels significantly correlated with age, tumor size, macroscopic type, histological grade, T stage and TNM stage. Kaplan–Meier curves revealed that patients with CA19-9 changes <20% had significant better overall survival than those with changes more than 20% (p < 0.001); Cox regression analysis revealed the CA19-9 change (p = 0.010), gender (p = 0.031), histological grade (p = 0.036) and TNM stage (p < 0.001) were independent risk factors for survival after PSM. Stratification analysis indicated that patients with CA19-9 change more than 20% had worse prognosis that those with CA19-9 change no more than 20% in male (p = 0.002), poorly differentiated or undifferentiated type (p = 0.031) and TNM stage III (p = 0.006).Conclusion: Changes in preoperative and postoperative serum CA19-9 levels were closely associated with clinicopathological traits and was an independent prognostic factor in gastric cancer patients. This parameter may be a reliable marker for prediction of survival. |
| first_indexed | 2024-12-12T23:04:47Z |
| format | Article |
| id | doaj.art-dfef5f82dc63459e87dd9fc91f33d96b |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-12T23:04:47Z |
| publishDate | 2020-08-01 |
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| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-dfef5f82dc63459e87dd9fc91f33d96b2022-12-22T00:08:44ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-08-011010.3389/fonc.2020.01432528866Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric CancerXiao-Hai Song0Xiao-Hai Song1Kai Liu2Kai Liu3Shi-Jie Yang4Shi-Jie Yang5Wei-Han Zhang6Wei-Han Zhang7Xiao-Long Chen8Xiao-Long Chen9Lin-Yong Zhao10Lin-Yong Zhao11Xin-Zu Chen12Xin-Zu Chen13Kun Yang14Kun Yang15Zong-Guang Zhou16Zong-Guang Zhou17Jian-Kun Hu18Jian-Kun Hu19Department of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Digestive Surgery, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Gastrointestinal Surgery, West China Hospital, Sichuan University, Chengdu, ChinaLaboratory of Gastric Cancer, State Key Laboratory of Biotherapy, Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, ChinaObjective: The prognostic significance of serum CA19-9 levels in gastric cancer patients remains a matter debate. The aim of this study was to determine the prognostic value of changes in preoperative and postoperative serum CA19-9 levels in patients with gastric cancer.Methods: A total of 1,046 gastric cancer patients who underwent curative gastrectomy in West China Hospital of Sichuan University from January 2011 to December 2016 were analyzed retrospectively. Patients were categorized by minimum P-value using X-tile, while the baseline confounders for CA19-9 changes were balanced through propensity score matching (PSM). The relationships between CA19-9 changes and other clinicopathologic features were measured. Univariate and multivariate analysis were performed to explore the risk factors associated with survival outcomes.Results: We included 653 patients. Changes in CA19-9 levels significantly correlated with age, tumor size, macroscopic type, histological grade, T stage and TNM stage. Kaplan–Meier curves revealed that patients with CA19-9 changes <20% had significant better overall survival than those with changes more than 20% (p < 0.001); Cox regression analysis revealed the CA19-9 change (p = 0.010), gender (p = 0.031), histological grade (p = 0.036) and TNM stage (p < 0.001) were independent risk factors for survival after PSM. Stratification analysis indicated that patients with CA19-9 change more than 20% had worse prognosis that those with CA19-9 change no more than 20% in male (p = 0.002), poorly differentiated or undifferentiated type (p = 0.031) and TNM stage III (p = 0.006).Conclusion: Changes in preoperative and postoperative serum CA19-9 levels were closely associated with clinicopathological traits and was an independent prognostic factor in gastric cancer patients. This parameter may be a reliable marker for prediction of survival.https://www.frontiersin.org/article/10.3389/fonc.2020.01432/fullgastric cancerCA19-9prognosisgastrectomyoverall survival |
| spellingShingle | Xiao-Hai Song Xiao-Hai Song Kai Liu Kai Liu Shi-Jie Yang Shi-Jie Yang Wei-Han Zhang Wei-Han Zhang Xiao-Long Chen Xiao-Long Chen Lin-Yong Zhao Lin-Yong Zhao Xin-Zu Chen Xin-Zu Chen Kun Yang Kun Yang Zong-Guang Zhou Zong-Guang Zhou Jian-Kun Hu Jian-Kun Hu Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer Frontiers in Oncology gastric cancer CA19-9 prognosis gastrectomy overall survival |
| title | Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer |
| title_full | Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer |
| title_fullStr | Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer |
| title_full_unstemmed | Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer |
| title_short | Prognostic Value of Changes in Preoperative and Postoperative Serum CA19-9 Levels in Gastric Cancer |
| title_sort | prognostic value of changes in preoperative and postoperative serum ca19 9 levels in gastric cancer |
| topic | gastric cancer CA19-9 prognosis gastrectomy overall survival |
| url | https://www.frontiersin.org/article/10.3389/fonc.2020.01432/full |
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