Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell–Cell Junctions

Protein Phosphatase 2A: More Than a Passenger in the Regulation of Epithelial Cell–Cell Junctions

Cell–cell adhesion plays a key role in the maintenance of the epithelial barrier and apicobasal cell polarity, which is crucial for homeostasis. Disruption of cell–cell adhesion is a hallmark of numerous pathological conditions, including invasive carcinomas. Adhesion between apposing cells is prima...

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Bibliographic Details
Main Authors: Diana Schuhmacher, Jean-Marie Sontag, Estelle Sontag
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
adherens junction
dephosphorylation
desmosome
polarity
PP2A
signaling
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2019.00030/full

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