Results of implementation of viral hepatitis B elimination program in the North-West Russia
Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the distri...
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| Format: | Article |
| Language: | Russian |
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Sankt-Peterburg : NIIÈM imeni Pastera
2021-11-01
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| Series: | Инфекция и иммунитет |
| Subjects: | |
| Online Access: | https://www.iimmun.ru/iimm/article/view/1785 |
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| author | L. V. Lyalina E. V. Esaulenko E. V. Khorkova K. E. Novak Y. V. Ostankova E. N. Serikova D. V. Vasilyev E. S. Gorziy M. J. Butskaya I. V. Kritskaya L. V. Buts E. V. Grebenkina E. V. Baydakova N. A. Smirnova M. A. Krasnopyorova N. S. Koltsov L. M. Kotovich E. L. Kalinina R. R. Galimov N. V. Kirkhar E. A. Cherepanova Areg A. Totolian |
| author_facet | L. V. Lyalina E. V. Esaulenko E. V. Khorkova K. E. Novak Y. V. Ostankova E. N. Serikova D. V. Vasilyev E. S. Gorziy M. J. Butskaya I. V. Kritskaya L. V. Buts E. V. Grebenkina E. V. Baydakova N. A. Smirnova M. A. Krasnopyorova N. S. Koltsov L. M. Kotovich E. L. Kalinina R. R. Galimov N. V. Kirkhar E. A. Cherepanova Areg A. Totolian |
| author_sort | L. V. Lyalina |
| collection | DOAJ |
| description | Introduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection. |
| first_indexed | 2024-04-11T03:29:34Z |
| format | Article |
| id | doaj.art-dff0fbc48a764389b521a597e300be82 |
| institution | Directory Open Access Journal |
| issn | 2220-7619 2313-7398 |
| language | Russian |
| last_indexed | 2024-04-11T03:29:34Z |
| publishDate | 2021-11-01 |
| publisher | Sankt-Peterburg : NIIÈM imeni Pastera |
| record_format | Article |
| series | Инфекция и иммунитет |
| spelling | doaj.art-dff0fbc48a764389b521a597e300be822023-01-02T06:40:31ZrusSankt-Peterburg : NIIÈM imeni PasteraИнфекция и иммунитет2220-76192313-73982021-11-0111587588610.15789/2220-7619-ROT-17851039Results of implementation of viral hepatitis B elimination program in the North-West RussiaL. V. Lyalina0E. V. Esaulenko1E. V. Khorkova2K. E. Novak3Y. V. Ostankova4E. N. Serikova5D. V. Vasilyev6E. S. Gorziy7M. J. Butskaya8I. V. Kritskaya9L. V. Buts10E. V. Grebenkina11E. V. Baydakova12N. A. Smirnova13M. A. Krasnopyorova14N. S. Koltsov15L. M. Kotovich16E. L. Kalinina17R. R. Galimov18N. V. Kirkhar19E. A. Cherepanova20Areg A. Totolian21St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. MechnikovSt. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical UniversityLeningrad Regional Center for the Prevention and Control of AIDS and Infectious DiseasesSt. Petersburg State Pediatric Medical UniversitySt. Petersburg Pasteur InstituteSt. Petersburg Pasteur InstitutePolyclinic No. 48St. Petersburg Pasteur Institute; North-Western State Medical University named after I.I. MechnikovSt. Petersburg Pasteur Institute; St. Petersburg State Pediatric Medical UniversityRospotrebnadzor Office for St. PetersburgRospotrebnadzor Office for Leningrad RegionRospotrebnadzor Office for Novgorod RegionRospotrebnadzor Office for Arkhangelsk Region; Northern State Medical University of the Ministry of Health of Russian FederationRospotrebnadzor Office for Vologda RegionRospotrebnadzor Office for Kaliningrad RegionRospotrebnadzor Office for Murmansk RegionRospotrebnadzor Office for the Republic of KareliaRospotrebnadzor Office for Pskov RegionRospotrebnadzor Office for Komi RepublicRospotrebnadzor Office for Nenets Autonomous OkrugFederal Center of Hygiene and EpidemiologySt. Petersburg Pasteur InstituteIntroduction. Vaccination contributed to reduce the incidence of acute hepatitis B in the territories of the North-West Russia. The urgency of this problem remains due to the high incidence of chronic hepatitis B. This accounted for the need to develop a hepatitis B elimination program in the district discussed that was approved in 2013 by the head of the Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing. Objective is to characterize the results of the program for the elimination of acute hepatitis B virus implemented in the North-Western Federal District. Materials and methods. The 2010–2020 incidence rate of acute and chronic hepatitis B virus (HBV) infection in the regions of the North-West Russia was carried out. To determine HBV genotypes and subgenotypes, 160 blood plasma samples from patients with acute hepatitis B were studied using molecular genetic methods (PCR, sequencing). The prevalence of latent hepatitis B in various population groups was assessed. The 2016–2020 hepatitis B vaccination coverage and relevant serological monitoring in adults was carried out. Results. While implementing the program, it was found that the incidence rate of acute hepatitis B in the district decreased by 4.5-fold, revealing in 2020 no cases of the disease in 5 regions, with incidence rate in the 6 subfederal units being lower than 1.0 per 100,000 population. Moreover, the incidence rate for chronic hepatitis B decreased by 2.6 times. The 2020 vaccination coverage of children under 17 and adults in all territories comprised more than 95% and 90%, respectively. In addition, it was shown the circulation of genotypes D and A of hepatitis B virus is dominated by genotype D (91.8%), subgenotype D2 (47.8%). The prevalence of latent hepatitis B among migrants was 6.5%, pregnant women — 4.9%, hemodialysis patients — 1.7%. Conclusion. Implementation of the program on elimination of acute viral hepatitis B in the territory of the North-West Russia contributed to raise in the vaccination coverage in adult population and lowered incidence rate of acute and chronic HBV infection.https://www.iimmun.ru/iimm/article/view/1785hepatitis b virusmorbiditygenotypesvaccinationelimination |
| spellingShingle | L. V. Lyalina E. V. Esaulenko E. V. Khorkova K. E. Novak Y. V. Ostankova E. N. Serikova D. V. Vasilyev E. S. Gorziy M. J. Butskaya I. V. Kritskaya L. V. Buts E. V. Grebenkina E. V. Baydakova N. A. Smirnova M. A. Krasnopyorova N. S. Koltsov L. M. Kotovich E. L. Kalinina R. R. Galimov N. V. Kirkhar E. A. Cherepanova Areg A. Totolian Results of implementation of viral hepatitis B elimination program in the North-West Russia Инфекция и иммунитет hepatitis b virus morbidity genotypes vaccination elimination |
| title | Results of implementation of viral hepatitis B elimination program in the North-West Russia |
| title_full | Results of implementation of viral hepatitis B elimination program in the North-West Russia |
| title_fullStr | Results of implementation of viral hepatitis B elimination program in the North-West Russia |
| title_full_unstemmed | Results of implementation of viral hepatitis B elimination program in the North-West Russia |
| title_short | Results of implementation of viral hepatitis B elimination program in the North-West Russia |
| title_sort | results of implementation of viral hepatitis b elimination program in the north west russia |
| topic | hepatitis b virus morbidity genotypes vaccination elimination |
| url | https://www.iimmun.ru/iimm/article/view/1785 |
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