Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease
Case summary A 5-year-old male neutered Persian cat was referred for investigation of a 4 week history of weight loss, inappetence and intermittent vomiting. Chronic kidney disease (CKD) and inflammatory bowel disease were diagnosed, and despite immunosuppressive therapy and assisted enteral nutriti...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2018-07-01
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| Series: | Journal of Feline Medicine and Surgery Open Reports |
| Online Access: | https://doi.org/10.1177/2055116918786750 |
| _version_ | 1818524335270264832 |
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| author | Cécile Dor Jessica L Adamany Caroline Kisielewicz Simone de Brot Kerstin Erles Marc P Dhumeaux |
| author_facet | Cécile Dor Jessica L Adamany Caroline Kisielewicz Simone de Brot Kerstin Erles Marc P Dhumeaux |
| author_sort | Cécile Dor |
| collection | DOAJ |
| description | Case summary A 5-year-old male neutered Persian cat was referred for investigation of a 4 week history of weight loss, inappetence and intermittent vomiting. Chronic kidney disease (CKD) and inflammatory bowel disease were diagnosed, and despite immunosuppressive therapy and assisted enteral nutrition, the cat experienced persistent anorexia, vomiting and severe weight loss. After 2 additional weeks of treatment, the cat developed acute-onset neurological signs associated with severe hyperammonaemia and was euthanased. Plasma amino acid assessment revealed deficiency of several amino acids involved in the urea cycle, including arginine. Relevance and novel information To our knowledge, this is the first reported case of an acquired urea cycle amino acid deficiency without nutritional deprivation in a cat. Several contributing factors were suspected, including intestinal malabsorption and CKD. This case demonstrates the importance of urea cycle amino acids in feline metabolism and possible necessity for parenteral supplementation, particularly in the context of persistent weight loss despite adequate enteral nutrition. |
| first_indexed | 2024-12-11T05:55:44Z |
| format | Article |
| id | doaj.art-dff35e6b602d4fdc9a1c03c7285b75fa |
| institution | Directory Open Access Journal |
| issn | 2055-1169 |
| language | English |
| last_indexed | 2024-12-11T05:55:44Z |
| publishDate | 2018-07-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Journal of Feline Medicine and Surgery Open Reports |
| spelling | doaj.art-dff35e6b602d4fdc9a1c03c7285b75fa2022-12-22T01:18:41ZengSAGE PublishingJournal of Feline Medicine and Surgery Open Reports2055-11692018-07-01410.1177/2055116918786750Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney diseaseCécile Dor0Jessica L Adamany1Caroline Kisielewicz2Simone de Brot3Kerstin Erles4Marc P Dhumeaux5Department of Internal Medicine, Pride Veterinary Centre, Derby, UKDepartment of Internal Medicine, Pride Veterinary Centre, Derby, UKDepartment of Internal Medicine, Pride Veterinary Centre, Derby, UKSchool of Veterinary Medicine and Science, University of Nottingham, Nottingham, UKBridge Pathology, Bristol, UKDepartment of Internal Medicine, Pride Veterinary Centre, Derby, UKCase summary A 5-year-old male neutered Persian cat was referred for investigation of a 4 week history of weight loss, inappetence and intermittent vomiting. Chronic kidney disease (CKD) and inflammatory bowel disease were diagnosed, and despite immunosuppressive therapy and assisted enteral nutrition, the cat experienced persistent anorexia, vomiting and severe weight loss. After 2 additional weeks of treatment, the cat developed acute-onset neurological signs associated with severe hyperammonaemia and was euthanased. Plasma amino acid assessment revealed deficiency of several amino acids involved in the urea cycle, including arginine. Relevance and novel information To our knowledge, this is the first reported case of an acquired urea cycle amino acid deficiency without nutritional deprivation in a cat. Several contributing factors were suspected, including intestinal malabsorption and CKD. This case demonstrates the importance of urea cycle amino acids in feline metabolism and possible necessity for parenteral supplementation, particularly in the context of persistent weight loss despite adequate enteral nutrition.https://doi.org/10.1177/2055116918786750 |
| spellingShingle | Cécile Dor Jessica L Adamany Caroline Kisielewicz Simone de Brot Kerstin Erles Marc P Dhumeaux Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease Journal of Feline Medicine and Surgery Open Reports |
| title | Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease |
| title_full | Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease |
| title_fullStr | Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease |
| title_full_unstemmed | Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease |
| title_short | Acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease |
| title_sort | acquired urea cycle amino acid deficiency and hyperammonaemic encephalopathy in a cat with inflammatory bowel disease and chronic kidney disease |
| url | https://doi.org/10.1177/2055116918786750 |
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