Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity
Neuropeptide Y (NPY) and peptide YY (PYY) are involved in metabolic regulation. The purpose of the study was to assess the serum levels of NPY and PYY in adolescents with anorexia nervosa (AN) or obesity (OB), as well as in a healthy control group (CG). The effects of potential confounders on their...
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MDPI AG
2021-02-01
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| Online Access: | https://www.mdpi.com/2072-6643/13/2/598 |
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| author | Marta Tyszkiewicz-Nwafor Katarzyna Jowik Agata Dutkiewicz Agata Krasinska Natalia Pytlinska Monika Dmitrzak-Weglarz Marta Suminska Agata Pruciak Bogda Skowronska Agnieszka Slopien |
| author_facet | Marta Tyszkiewicz-Nwafor Katarzyna Jowik Agata Dutkiewicz Agata Krasinska Natalia Pytlinska Monika Dmitrzak-Weglarz Marta Suminska Agata Pruciak Bogda Skowronska Agnieszka Slopien |
| author_sort | Marta Tyszkiewicz-Nwafor |
| collection | DOAJ |
| description | Neuropeptide Y (NPY) and peptide YY (PYY) are involved in metabolic regulation. The purpose of the study was to assess the serum levels of NPY and PYY in adolescents with anorexia nervosa (AN) or obesity (OB), as well as in a healthy control group (CG). The effects of potential confounders on their concentrations were also analysed. Eighty-nine adolescents were included in this study (AN = 30, OB = 30, and CG = 29). Anthropometric measurements and psychometric assessment of depressive symptoms, eating behaviours, body attitudes, and fasting serum levels of NPY and PYY were analysed. The AN group presented severe depressive symptoms, while the OB group held different attitudes towards the body. The levels of NPY were lower in the AN and OB groups as compared with the CG. The PYY levels were higher in the OB group than in the AN group and the CG. The severity of eating disorder symptoms predicted fasting serum concentrations of NPY. Lower levels of NPY in AN, as well as in OB suggests the need to look for a common link in the mechanism of this effect. Higher level of PYY in OB may be important in explaining complex etiopathogenesis of the disease. The psychopathological symptoms may have an influence on the neurohormones regulating metabolism. |
| first_indexed | 2024-03-09T00:58:08Z |
| format | Article |
| id | doaj.art-dff36e0406ba42de95299bde899984ff |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T00:58:08Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-dff36e0406ba42de95299bde899984ff2023-12-11T16:46:35ZengMDPI AGNutrients2072-66432021-02-0113259810.3390/nu13020598Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to ObesityMarta Tyszkiewicz-Nwafor0Katarzyna Jowik1Agata Dutkiewicz2Agata Krasinska3Natalia Pytlinska4Monika Dmitrzak-Weglarz5Marta Suminska6Agata Pruciak7Bogda Skowronska8Agnieszka Slopien9Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, PolandPsychiatric Genetics Unit, Department of Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, 61-701 Poznan, PolandInstitute of Plant Protection—National Research Institute, Research Centre of Quarantine, Invasive and Genetically Modified Organisms, 60-318 Poznan, PolandDepartment of Pediatric Diabetes and Obesity, Poznan University of Medical Sciences, 61-701 Poznan, PolandDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, 61-701 Poznan, PolandNeuropeptide Y (NPY) and peptide YY (PYY) are involved in metabolic regulation. The purpose of the study was to assess the serum levels of NPY and PYY in adolescents with anorexia nervosa (AN) or obesity (OB), as well as in a healthy control group (CG). The effects of potential confounders on their concentrations were also analysed. Eighty-nine adolescents were included in this study (AN = 30, OB = 30, and CG = 29). Anthropometric measurements and psychometric assessment of depressive symptoms, eating behaviours, body attitudes, and fasting serum levels of NPY and PYY were analysed. The AN group presented severe depressive symptoms, while the OB group held different attitudes towards the body. The levels of NPY were lower in the AN and OB groups as compared with the CG. The PYY levels were higher in the OB group than in the AN group and the CG. The severity of eating disorder symptoms predicted fasting serum concentrations of NPY. Lower levels of NPY in AN, as well as in OB suggests the need to look for a common link in the mechanism of this effect. Higher level of PYY in OB may be important in explaining complex etiopathogenesis of the disease. The psychopathological symptoms may have an influence on the neurohormones regulating metabolism.https://www.mdpi.com/2072-6643/13/2/598anorexia nervosaobesityneuropeptide Y family |
| spellingShingle | Marta Tyszkiewicz-Nwafor Katarzyna Jowik Agata Dutkiewicz Agata Krasinska Natalia Pytlinska Monika Dmitrzak-Weglarz Marta Suminska Agata Pruciak Bogda Skowronska Agnieszka Slopien Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity Nutrients anorexia nervosa obesity neuropeptide Y family |
| title | Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity |
| title_full | Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity |
| title_fullStr | Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity |
| title_full_unstemmed | Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity |
| title_short | Neuropeptide Y and Peptide YY in Association with Depressive Symptoms and Eating Behaviours in Adolescents across the Weight Spectrum: From Anorexia Nervosa to Obesity |
| title_sort | neuropeptide y and peptide yy in association with depressive symptoms and eating behaviours in adolescents across the weight spectrum from anorexia nervosa to obesity |
| topic | anorexia nervosa obesity neuropeptide Y family |
| url | https://www.mdpi.com/2072-6643/13/2/598 |
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