Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics
Active surveillance is the preferred strategy for very low risk, low risk, and some favorable intermediate risk of prostate cancer. However, the current risk stratifications with initial prostate-specific antigen (iPSA) levels and Gleason scores at biopsy can underestimate the true oncologic threat....
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| Format: | Article |
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MDPI AG
2020-08-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/10/9/656 |
| _version_ | 1797555015475265536 |
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| author | Ju-Chuan Hu Chia-Yen Lin Shian-Shiang Wang Kun-Yuan Chiu Jian-Ri Li Chuan-Shu Chen Sheng-Chun Hung Cheng-Kuang Yang Yen-Chuan Ou Chen-Li Cheng Shun-Fa Yang |
| author_facet | Ju-Chuan Hu Chia-Yen Lin Shian-Shiang Wang Kun-Yuan Chiu Jian-Ri Li Chuan-Shu Chen Sheng-Chun Hung Cheng-Kuang Yang Yen-Chuan Ou Chen-Li Cheng Shun-Fa Yang |
| author_sort | Ju-Chuan Hu |
| collection | DOAJ |
| description | Active surveillance is the preferred strategy for very low risk, low risk, and some favorable intermediate risk of prostate cancer. However, the current risk stratifications with initial prostate-specific antigen (iPSA) levels and Gleason scores at biopsy can underestimate the true oncologic threat. More precise predictors are required to avoid the overtreatment of prostate cancer. H19 single-nucleotide polymorphisms (SNPs) have been found to play crucial roles in numerous malignancies, but not yet in prostate cancer. This study assessed the clinicopathologic effects of H19 SNPs on prostate cancer to identify potential active surveillance candidates. A total of 579 patients with prostate cancer who underwent robot-assisted radical prostatectomy between 2012 and 2017 were recruited. The patients were grouped by iPSA levels, and five H19 SNPs were evaluated. Our results show that patients with an iPSA level of ≤7 ng/mL had increased an likelihood of having Gleason score and group grade upgrades after radical prostatectomy compared with patients with an iPSA level of >7 ng/mL. Moreover, patients with loci polymorphisms in either rs3024270 or rs3741219 had a significantly higher risk of perineural invasion (rs3024270: Odds ratio (OR) 2.76, 95% confidence interval (CI) 1.30–5.87, <i>p</i> = 0.01; rs3741219: OR 2.30, 95% CI 1.17–4.54, <i>p</i> = 0.018). In conclusion, our results suggested that H19 SNPs play a role in the perineural invasion of prostate cancer. |
| first_indexed | 2024-03-10T16:41:17Z |
| format | Article |
| id | doaj.art-dff5b078fc5748c9ad80739f6d5e4c6d |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-10T16:41:17Z |
| publishDate | 2020-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-dff5b078fc5748c9ad80739f6d5e4c6d2023-11-20T12:02:45ZengMDPI AGDiagnostics2075-44182020-08-0110965610.3390/diagnostics10090656Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic CharacteristicsJu-Chuan Hu0Chia-Yen Lin1Shian-Shiang Wang2Kun-Yuan Chiu3Jian-Ri Li4Chuan-Shu Chen5Sheng-Chun Hung6Cheng-Kuang Yang7Yen-Chuan Ou8Chen-Li Cheng9Shun-Fa Yang10Institute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanDivision of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanInstitute of Medicine, Chung Shan Medical University, Taichung 402, TaiwanActive surveillance is the preferred strategy for very low risk, low risk, and some favorable intermediate risk of prostate cancer. However, the current risk stratifications with initial prostate-specific antigen (iPSA) levels and Gleason scores at biopsy can underestimate the true oncologic threat. More precise predictors are required to avoid the overtreatment of prostate cancer. H19 single-nucleotide polymorphisms (SNPs) have been found to play crucial roles in numerous malignancies, but not yet in prostate cancer. This study assessed the clinicopathologic effects of H19 SNPs on prostate cancer to identify potential active surveillance candidates. A total of 579 patients with prostate cancer who underwent robot-assisted radical prostatectomy between 2012 and 2017 were recruited. The patients were grouped by iPSA levels, and five H19 SNPs were evaluated. Our results show that patients with an iPSA level of ≤7 ng/mL had increased an likelihood of having Gleason score and group grade upgrades after radical prostatectomy compared with patients with an iPSA level of >7 ng/mL. Moreover, patients with loci polymorphisms in either rs3024270 or rs3741219 had a significantly higher risk of perineural invasion (rs3024270: Odds ratio (OR) 2.76, 95% confidence interval (CI) 1.30–5.87, <i>p</i> = 0.01; rs3741219: OR 2.30, 95% CI 1.17–4.54, <i>p</i> = 0.018). In conclusion, our results suggested that H19 SNPs play a role in the perineural invasion of prostate cancer.https://www.mdpi.com/2075-4418/10/9/656H19prostate cancerpolymorphismoutcome |
| spellingShingle | Ju-Chuan Hu Chia-Yen Lin Shian-Shiang Wang Kun-Yuan Chiu Jian-Ri Li Chuan-Shu Chen Sheng-Chun Hung Cheng-Kuang Yang Yen-Chuan Ou Chen-Li Cheng Shun-Fa Yang Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics Diagnostics H19 prostate cancer polymorphism outcome |
| title | Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics |
| title_full | Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics |
| title_fullStr | Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics |
| title_full_unstemmed | Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics |
| title_short | Impact of H19 Polymorphisms on Prostate Cancer Clinicopathologic Characteristics |
| title_sort | impact of h19 polymorphisms on prostate cancer clinicopathologic characteristics |
| topic | H19 prostate cancer polymorphism outcome |
| url | https://www.mdpi.com/2075-4418/10/9/656 |
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