Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry

Quantitative Determination of Unbound Piperacillin and Imipenem in Biological Material from Critically Ill Using Thin-Film Microextraction-Liquid Chromatography-Mass Spectrometry

β-Lactam antibiotics are most commonly used in the critically ill, but their effective dosing is challenging and may result in sub-therapeutic concentrations that can lead to therapy failure and even promote antimicrobial resistance. In this study, we present the analytical tool enabling specific an...

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Bibliographic Details
Main Authors: Robert Włodarski, Karolina Żuchowska, Wojciech Filipiak
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Molecules
Subjects:
β-Lactam antibiotics
imipenem
piperacillin
ventilation-associated pneumonia (VAP)
therapeutic drug monitoring (TDM)
personalized therapy
Online Access:https://www.mdpi.com/1420-3049/27/3/926

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