Serotonin in the regulation of systemic energy metabolism
Abstract Serotonin is a well‐known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been discovered; they exist universally in our body and enable diverse biological functions in different organs. Central serotonin regulat...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-10-01
|
| Series: | Journal of Diabetes Investigation |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jdi.13879 |
| _version_ | 1811199038132846592 |
|---|---|
| author | Joon Ho Moon Chang‐Myung Oh Hail Kim |
| author_facet | Joon Ho Moon Chang‐Myung Oh Hail Kim |
| author_sort | Joon Ho Moon |
| collection | DOAJ |
| description | Abstract Serotonin is a well‐known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been discovered; they exist universally in our body and enable diverse biological functions in different organs. Central serotonin regulates mood and behavior, and impacts the systemic energy balance by decreasing appetite. A number of drugs that modulate central serotonin function (e.g., fenfluramine, sibutramine and lorcaserin) were approved and used as anti‐obesity drugs, but then later withdrawn due to adverse cardiovascular and carcinogenic effects. Over the past decade, the role of peripheral serotonin in regulating systemic energy metabolism has been extensively explored using tissue‐specific knockout animal models. By inhibiting the action of serotonin in liver and adipose tissues, hepatic steatosis was improved and lipid accumulation was mitigated, respectively. Recent findings show that modulation of the serotonergic system is a promising therapeutic target for metabolic diseases. This review summarizes the role of serotonin in regulating energy metabolism in different organs, and discusses the potential of serotonin modulation for treating metabolic diseases. |
| first_indexed | 2024-04-12T01:41:10Z |
| format | Article |
| id | doaj.art-dff83e661df748668745ab74aeaa43ae |
| institution | Directory Open Access Journal |
| issn | 2040-1116 2040-1124 |
| language | English |
| last_indexed | 2024-04-12T01:41:10Z |
| publishDate | 2022-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Investigation |
| spelling | doaj.art-dff83e661df748668745ab74aeaa43ae2022-12-22T03:53:12ZengWileyJournal of Diabetes Investigation2040-11162040-11242022-10-0113101639164510.1111/jdi.13879Serotonin in the regulation of systemic energy metabolismJoon Ho Moon0Chang‐Myung Oh1Hail Kim2Department of Internal Medicine Seoul National University Bundang Hospital, Seoul National University College of Medicine Seoul South KoreaDepartment of Biomedical Science and Engineering Gwangju Institute of Science and Technology Gwangju South KoreaGraduate School of Medical Science and Engineering Korea Advanced Institute of Science and Technology Daejeon South KoreaAbstract Serotonin is a well‐known neurotransmitter that is synthesized from the amino acid, tryptophan. To date, more than 14 different serotonin receptors have been discovered; they exist universally in our body and enable diverse biological functions in different organs. Central serotonin regulates mood and behavior, and impacts the systemic energy balance by decreasing appetite. A number of drugs that modulate central serotonin function (e.g., fenfluramine, sibutramine and lorcaserin) were approved and used as anti‐obesity drugs, but then later withdrawn due to adverse cardiovascular and carcinogenic effects. Over the past decade, the role of peripheral serotonin in regulating systemic energy metabolism has been extensively explored using tissue‐specific knockout animal models. By inhibiting the action of serotonin in liver and adipose tissues, hepatic steatosis was improved and lipid accumulation was mitigated, respectively. Recent findings show that modulation of the serotonergic system is a promising therapeutic target for metabolic diseases. This review summarizes the role of serotonin in regulating energy metabolism in different organs, and discusses the potential of serotonin modulation for treating metabolic diseases.https://doi.org/10.1111/jdi.13879MetabolismSerotonin |
| spellingShingle | Joon Ho Moon Chang‐Myung Oh Hail Kim Serotonin in the regulation of systemic energy metabolism Journal of Diabetes Investigation Metabolism Serotonin |
| title | Serotonin in the regulation of systemic energy metabolism |
| title_full | Serotonin in the regulation of systemic energy metabolism |
| title_fullStr | Serotonin in the regulation of systemic energy metabolism |
| title_full_unstemmed | Serotonin in the regulation of systemic energy metabolism |
| title_short | Serotonin in the regulation of systemic energy metabolism |
| title_sort | serotonin in the regulation of systemic energy metabolism |
| topic | Metabolism Serotonin |
| url | https://doi.org/10.1111/jdi.13879 |
| work_keys_str_mv | AT joonhomoon serotoninintheregulationofsystemicenergymetabolism AT changmyungoh serotoninintheregulationofsystemicenergymetabolism AT hailkim serotoninintheregulationofsystemicenergymetabolism |