Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus

Molecular Genetics of Abnormal Redox Homeostasis in Type 2 Diabetes Mellitus

Numerous studies have shown that oxidative stress resulting from an imbalance between the production of free radicals and their neutralization by antioxidant enzymes is one of the major pathological disorders underlying the development and progression of type 2 diabetes (T2D). The present review sum...

Full description

Bibliographic Details
Main Authors:	Iuliia Azarova, Alexey Polonikov, Elena Klyosova
Format:	Article
Language:	English
Published:	MDPI AG 2023-03-01
Series:	International Journal of Molecular Sciences
Subjects:	type 2 diabetes genetic susceptibility molecular mechanisms oxidative stress redox homeostasis glutathione metabolism
Online Access:	https://www.mdpi.com/1422-0067/24/5/4738

Similar Items

Differentially Expressed Genes Regulating Glutathione Metabolism, Protein-Folding, and Unfolded Protein Response in Pancreatic β-Cells in Type 2 Diabetes Mellitus
by: Elena Klyosova, et al.
Published: (2023-07-01)

The Link between Type 2 Diabetes Mellitus and the Polymorphisms of Glutathione-Metabolizing Genes Suggests a New Hypothesis Explaining Disease Initiation and Progression
by: Iuliia Azarova, et al.
Published: (2021-08-01)

Glutathione and peroxisome redox homeostasis
by: Maria J. Ferreira, et al.
Published: (2023-11-01)

A Polymorphism in the Gene Encoding Heat Shock Factor 1 (<i>HSF1</i>) Increases the Risk of Type 2 Diabetes: A Pilot Study Supports a Role for Impaired Protein Folding in Disease Pathogenesis
by: Elena Klyosova, et al.
Published: (2022-11-01)

Glutathione and Glutaredoxin—Key Players in Cellular Redox Homeostasis and Signaling
by: Yuh-Cherng Chai, et al.
Published: (2023-08-01)

Glutathione-dependent redox homeostasis is critical for chlorothalonil detoxification in tomato leaves
by: Gao-Bo Yu, et al.
Published: (2023-12-01)

Clove bud (Syzygium aromaticum L.) polyphenol helps to mitigate metabolic syndrome by establishing intracellular redox homeostasis and glucose metabolism: A randomized, double-blinded, active-controlled comparative study
by: Jestin Thomas, et al.
Published: (2022-11-01)

Redox Homeostasis and Regulation in Pluripotent Stem Cells: Uniqueness or Versatility?
by: Julia S. Ivanova, et al.
Published: (2021-10-01)

Thylakoid Rhodanese-like Protein–Ferredoxin:NADP<sup>+</sup> Oxidoreductase Interaction Is Integrated into Plant Redox Homeostasis System
by: Lea Vojta, et al.
Published: (2023-10-01)

The Impact of Spermidine on C2C12 Myoblasts Proliferation, Redox Status and Polyamines Metabolism under H<sub>2</sub>O<sub>2</sub> Exposure
by: Roberta Ceci, et al.
Published: (2022-09-01)

Visualization of the Redox Status of Cytosolic Glutathione Using the Organelle- and Cytoskeleton-Targeted Redox Sensors
by: Yuta Hatori, et al.
Published: (2020-02-01)

Cellular Redox Homeostasis
by: Kristell Le Gal, et al.
Published: (2021-08-01)

Redox Homeostasis via Gene Families of Ascorbate-Glutathione Pathway
by: Prachi ePandey, et al.
Published: (2015-03-01)

The role of redox homeostasis biomarkers in clear cell renal cell carcinoma development and progression
by: Mihailović Smiljana, et al.
Published: (2022-01-01)

Multistability maintains redox homeostasis in human cells
by: Jo‐Hsi Huang, et al.
Published: (2021-10-01)

Methionine restriction - Association with redox homeostasis and implications on aging and diseases
by: Yuyu Zhang, et al.
Published: (2022-11-01)

Modulation of Subcellular Redox Homeostasis with Trialkylphosphines
by: Jade Nguyen
Published: (2022-04-01)

Single Nucleotide Polymorphisms of the <i>RAC1</i> Gene as Novel Susceptibility Markers for Neuropathy and Microvascular Complications in Type 2 Diabetes
by: Iuliia Azarova, et al.
Published: (2023-03-01)

Glutathione-Related Enzymes and Proteins: A Review
by: Janka Vašková, et al.
Published: (2023-02-01)

Nanoparticles as Tools to Target Redox Homeostasis in Cancer Cells
by: Francesco Ciccarese, et al.
Published: (2020-03-01)

Inflammation, Peripheral Signals and Redox Homeostasis in Athletes Who Practice Different Sports
by: Simone Luti, et al.
Published: (2020-10-01)

Intersection between Redox Homeostasis and Autophagy: Valuable Insights into Neurodegeneration
by: Hyungsun Park, et al.
Published: (2021-04-01)

Understanding Cellular Redox Homeostasis: A Challenge for Precision Medicine
by: Verena Tretter, et al.
Published: (2021-12-01)

Monitoring Dynamic Cellular Redox Homeostasis Using Fluorescence-Switchable Graphene Quantum Dots
by: Li, Nan, et al.
Published: (2017)

Uncovering the roles of Mycobacterium tuberculosis melH in redox and bioenergetic homeostasis: implications for antitubercular therapy
by: Yu-Ching Chen, et al.
Published: (2024-04-01)

Exercise Improves Redox Homeostasis and Mitochondrial Function in White Adipose Tissue
by: Leonardo Matta, et al.
Published: (2022-08-01)

Circadian Rhythms, Chrononutrition, Physical Training, and Redox Homeostasis—Molecular Mechanisms in Human Health
by: Cristina Manuela Drăgoi, et al.
Published: (2024-01-01)

Functional Analysis of GSTK1 in Peroxisomal Redox Homeostasis in HEK-293 Cells
by: Cláudio F. Costa, et al.
Published: (2023-06-01)

Hsp70 in Redox Homeostasis
by: Hong Zhang, et al.
Published: (2022-02-01)

Modulation of redox homeostasis: A strategy to overcome cancer drug resistance
by: Yang Li, et al.
Published: (2023-03-01)

Redox Homeostasis in Pancreatic β-Cells: From Development to Failure
by: Štěpánka Benáková, et al.
Published: (2021-03-01)

The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size
by: Alexey Polonikov, et al.
Published: (2022-04-01)

An Update on Phytochemicals in Redox Homeostasis: “Virtuous or Evil” in Cancer Chemoprevention?
by: Homa Fatma, et al.
Published: (2023-02-01)

Role of Gender in Regulation of Redox Homeostasis in Pulmonary Arterial Hypertension
by: Ruslan Rafikov, et al.
Published: (2019-05-01)

The flavohaemoprotein hmp maintains redox homeostasis in response to reactive oxygen and nitrogen species in Corynebacterium glutamicum
by: Ziqin Jiang, et al.
Published: (2023-08-01)

Hyperglycemia and Loss of Redox Homeostasis in COVID-19 Patients
by: María Elena Soto, et al.
Published: (2022-03-01)

Recent Advances in Cellular Signaling Interplay between Redox Metabolism and Autophagy Modulation in Cancer: An Overview of Molecular Mechanisms and Therapeutic Interventions
by: Md. Ataur Rahman, et al.
Published: (2023-02-01)

Redox Cycling Dioxonaphthoimidazoliums Disrupt Iron Homeostasis in Mycobacterium bovis Bacillus Calmette-Guérin
by: Ming Li, et al.
Published: (2022-12-01)

Mitochondrial calcium signaling and redox homeostasis in cardiac health and disease
by: Tudor-Alexandru Popoiu, et al.
Published: (2023-08-01)

The Keap1-Nrf2 system in cancers: Stress response and anabolic metabolism
by: Yoichiro eMitsuishi, et al.
Published: (2012-12-01)