The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities
<i>Dacryodes</i> Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethnobotanical uses, phytochemistry...
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MDPI AG
2023-05-01
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| Series: | Pharmaceuticals |
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| Online Access: | https://www.mdpi.com/1424-8247/16/5/775 |
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| author | Leseho Swana Bienvenu Tsakem Jacqueline V. Tembu Rémy B. Teponno Joy T. Folahan Jarmo-Charles Kalinski Alexandros Polyzois Guy Kamatou Louis P. Sandjo Jean Christopher Chamcheu Xavier Siwe-Noundou |
| author_facet | Leseho Swana Bienvenu Tsakem Jacqueline V. Tembu Rémy B. Teponno Joy T. Folahan Jarmo-Charles Kalinski Alexandros Polyzois Guy Kamatou Louis P. Sandjo Jean Christopher Chamcheu Xavier Siwe-Noundou |
| author_sort | Leseho Swana |
| collection | DOAJ |
| description | <i>Dacryodes</i> Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethnobotanical uses, phytochemistry, and bioactivities of <i>Dacryodes</i> species. The intent is to spur future research into isolating and identifying key active principles, secondary metabolites, and crude extracts, and evaluating their pharmacological and toxicological effects, as well as the mechanism of actions to understand their medicinal benefits. A systematic review of scientific electronic databases from 1963 to 2022 including Scifinder, Scopus, Pubmed, Springer Link, ResearchGate, Ethnobotany Research and Applications, Google Scholar, and ScienceDirect was conducted with a focus on <i>Dacryodes edulis</i> (G.Don) H.J. Lam and <i>Dacryodes rostrata</i> (Blume) H.J. Lam. Pharmacological data revealed that <i>D. edulis</i> isolates contain secondary metabolites and other phytochemical groups belonging to the terpenoids class with anti-microbial, anticancer, antidiabetic, antiinflammatory and hepatoprotective activities, highlighting its pharmacological potential in the therapy or management of diverse cancers, cardiovascular, and neurological diseases. Thus, phytochemicals and standardized extracts from <i>D. edulis</i> could offer safer and cost-effective chemopreventive and chemotherapeutic health benefits/regimen, or as alternative therapeutic remedy for several human diseases. Nevertheless, the therapeutic potential of most of the plants in the genus have not been exhaustively explored with regard to phytochemistry and pharmacology, but mostly complementary approaches lacking rigorous, scientific research-based knowledge. Therefore, the therapeutic potentials of the <i>Dacryodes</i> genus remain largely untapped, and comprehensive research is necessary to fully harness their medicinal properties. |
| first_indexed | 2024-03-11T03:24:50Z |
| format | Article |
| id | doaj.art-dff9025e4f1e4b6faf30e7bcd387abe4 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T03:24:50Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-dff9025e4f1e4b6faf30e7bcd387abe42023-11-18T02:49:47ZengMDPI AGPharmaceuticals1424-82472023-05-0116577510.3390/ph16050775The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological ActivitiesLeseho Swana0Bienvenu Tsakem1Jacqueline V. Tembu2Rémy B. Teponno3Joy T. Folahan4Jarmo-Charles Kalinski5Alexandros Polyzois6Guy Kamatou7Louis P. Sandjo8Jean Christopher Chamcheu9Xavier Siwe-Noundou10Department of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria 0208, South AfricaDepartment of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, CameroonDepartment of Chemistry, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South AfricaDepartment of Chemistry, Faculty of Science, University of Dschang, Dschang P.O. Box 67, CameroonSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USADepartment of Biochemistry and Microbiology, Rhodes University, Makhanda 6140, South AfricaDepartment of Biochemistry and Microbiology, Rhodes University, Makhanda 6140, South AfricaDepartment of Pharmaceutical Sciences, Faculty of Science, Tshwane University of Technology, Private Bag X680, Pretoria 0001, South AfricaDepartment of Chemistry, Federal University of Santa Catarina, Florianópolis 88040-900, BrazilSchool of Basic Pharmaceutical and Toxicological Sciences, College of Pharmacy, University of Louisiana at Monroe, Monroe, LA 71209, USADepartment of Pharmaceutical Sciences, School of Pharmacy, Sefako Makgatho Health Sciences University, P.O. Box 218, Pretoria 0208, South Africa<i>Dacryodes</i> Vahl. species, belonging to the Burseraceae family, are widely used in traditional medicine in tropical regions to treat a range of ailments including malaria, wounds, tonsillitis, and ringworms. This review discusses the distribution, ethnobotanical uses, phytochemistry, and bioactivities of <i>Dacryodes</i> species. The intent is to spur future research into isolating and identifying key active principles, secondary metabolites, and crude extracts, and evaluating their pharmacological and toxicological effects, as well as the mechanism of actions to understand their medicinal benefits. A systematic review of scientific electronic databases from 1963 to 2022 including Scifinder, Scopus, Pubmed, Springer Link, ResearchGate, Ethnobotany Research and Applications, Google Scholar, and ScienceDirect was conducted with a focus on <i>Dacryodes edulis</i> (G.Don) H.J. Lam and <i>Dacryodes rostrata</i> (Blume) H.J. Lam. Pharmacological data revealed that <i>D. edulis</i> isolates contain secondary metabolites and other phytochemical groups belonging to the terpenoids class with anti-microbial, anticancer, antidiabetic, antiinflammatory and hepatoprotective activities, highlighting its pharmacological potential in the therapy or management of diverse cancers, cardiovascular, and neurological diseases. Thus, phytochemicals and standardized extracts from <i>D. edulis</i> could offer safer and cost-effective chemopreventive and chemotherapeutic health benefits/regimen, or as alternative therapeutic remedy for several human diseases. Nevertheless, the therapeutic potential of most of the plants in the genus have not been exhaustively explored with regard to phytochemistry and pharmacology, but mostly complementary approaches lacking rigorous, scientific research-based knowledge. Therefore, the therapeutic potentials of the <i>Dacryodes</i> genus remain largely untapped, and comprehensive research is necessary to fully harness their medicinal properties.https://www.mdpi.com/1424-8247/16/5/775<i>Dacryodes</i><i>Dacryodes edulis</i>medicinal plantphytochemistrytropical diseasesbioactivity |
| spellingShingle | Leseho Swana Bienvenu Tsakem Jacqueline V. Tembu Rémy B. Teponno Joy T. Folahan Jarmo-Charles Kalinski Alexandros Polyzois Guy Kamatou Louis P. Sandjo Jean Christopher Chamcheu Xavier Siwe-Noundou The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities Pharmaceuticals <i>Dacryodes</i> <i>Dacryodes edulis</i> medicinal plant phytochemistry tropical diseases bioactivity |
| title | The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities |
| title_full | The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities |
| title_fullStr | The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities |
| title_full_unstemmed | The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities |
| title_short | The Genus <i>Dacryodes</i> Vahl.: Ethnobotany, Phytochemistry and Biological Activities |
| title_sort | genus i dacryodes i vahl ethnobotany phytochemistry and biological activities |
| topic | <i>Dacryodes</i> <i>Dacryodes edulis</i> medicinal plant phytochemistry tropical diseases bioactivity |
| url | https://www.mdpi.com/1424-8247/16/5/775 |
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