Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial
<p>Abstract</p> <p>Background</p> <p>Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure.</p&g...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-02-01
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| Series: | BMC Pulmonary Medicine |
| Online Access: | http://www.biomedcentral.com/1471-2466/11/8 |
| _version_ | 1811266309128716288 |
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| author | Pavord Ian D Olivenstein Ronald Siersted Hans Corris Paul A Niven Robert M Rubin Adalberto S Thomson Neil C McCormack David Laviolette Michel Shargill Narinder S Cox Gerard |
| author_facet | Pavord Ian D Olivenstein Ronald Siersted Hans Corris Paul A Niven Robert M Rubin Adalberto S Thomson Neil C McCormack David Laviolette Michel Shargill Narinder S Cox Gerard |
| author_sort | Pavord Ian D |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure.</p> <p>Methods</p> <p>Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta<sub>2</sub>-agonists and demonstrated worsening of asthma on long-acting-β<sub>2</sub>-agonist withdrawal. Following initial evaluation at 1 year, subjects were invited to participate in a 4 year safety study. Adverse events (AEs) and spirometry data were used to assess long-term safety out to 5 years post-BT.</p> <p>Results</p> <p>45 of 52 treated and 24 of 49 control group subjects participated in long-term follow-up of 5 years and 3 years respectively. The rate of respiratory adverse events (AEs/subject) was stable in years 2 to 5 following BT (1.2, 1.3, 1.2, and 1.1, respectively,). There was no increase in hospitalizations or emergency room visits for respiratory symptoms in Years 2, 3, 4, and 5 compared to Year 1. The FVC and FEV<sub>1 </sub>values showed no deterioration over the 5 year period in the BT group. Similar results were obtained for the Control group.</p> <p>Conclusions</p> <p>The absence of clinical complications (based on AE reporting) and the maintenance of stable lung function (no deterioration of FVC and FEV<sub>1</sub>) over a 5-year period post-BT in this group of patients with moderate to severe asthma support the long-term safety of the procedure out to 5 years.</p> |
| first_indexed | 2024-04-12T20:39:52Z |
| format | Article |
| id | doaj.art-dff9b622ec144a24879a60b85a27787d |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-04-12T20:39:52Z |
| publishDate | 2011-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-dff9b622ec144a24879a60b85a27787d2022-12-22T03:17:27ZengBMCBMC Pulmonary Medicine1471-24662011-02-01111810.1186/1471-2466-11-8Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trialPavord Ian DOlivenstein RonaldSiersted HansCorris Paul ANiven Robert MRubin Adalberto SThomson Neil CMcCormack DavidLaviolette MichelShargill Narinder SCox Gerard<p>Abstract</p> <p>Background</p> <p>Bronchial thermoplasty (BT) is a bronchoscopic procedure that improves asthma control by reducing excess airway smooth muscle. Treated patients have been followed out to 5 years to evaluate long-term safety of this procedure.</p> <p>Methods</p> <p>Patients enrolled in the Asthma Intervention Research Trial were on inhaled corticosteroids ≥200 μg beclomethasone or equivalent + long-acting-beta<sub>2</sub>-agonists and demonstrated worsening of asthma on long-acting-β<sub>2</sub>-agonist withdrawal. Following initial evaluation at 1 year, subjects were invited to participate in a 4 year safety study. Adverse events (AEs) and spirometry data were used to assess long-term safety out to 5 years post-BT.</p> <p>Results</p> <p>45 of 52 treated and 24 of 49 control group subjects participated in long-term follow-up of 5 years and 3 years respectively. The rate of respiratory adverse events (AEs/subject) was stable in years 2 to 5 following BT (1.2, 1.3, 1.2, and 1.1, respectively,). There was no increase in hospitalizations or emergency room visits for respiratory symptoms in Years 2, 3, 4, and 5 compared to Year 1. The FVC and FEV<sub>1 </sub>values showed no deterioration over the 5 year period in the BT group. Similar results were obtained for the Control group.</p> <p>Conclusions</p> <p>The absence of clinical complications (based on AE reporting) and the maintenance of stable lung function (no deterioration of FVC and FEV<sub>1</sub>) over a 5-year period post-BT in this group of patients with moderate to severe asthma support the long-term safety of the procedure out to 5 years.</p>http://www.biomedcentral.com/1471-2466/11/8 |
| spellingShingle | Pavord Ian D Olivenstein Ronald Siersted Hans Corris Paul A Niven Robert M Rubin Adalberto S Thomson Neil C McCormack David Laviolette Michel Shargill Narinder S Cox Gerard Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial BMC Pulmonary Medicine |
| title | Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial |
| title_full | Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial |
| title_fullStr | Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial |
| title_full_unstemmed | Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial |
| title_short | Long-term (5 year) safety of bronchial thermoplasty: Asthma Intervention Research (AIR) trial |
| title_sort | long term 5 year safety of bronchial thermoplasty asthma intervention research air trial |
| url | http://www.biomedcentral.com/1471-2466/11/8 |
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