The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion
Obesity and obesity-related diseases [type 2 diabetes, cardiovascular disease (CVD), and cancer] are becoming more common, which is a major public health concern. Metabolically healthy obesity (MHO) has become a type of obesity, accounting for a large proportion of obese people. MHO is still harmful...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-07-01
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| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2022.924649/full |
| _version_ | 1811224817216520192 |
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| author | Liqiang Su Yihe Pan Haichun Chen |
| author_facet | Liqiang Su Yihe Pan Haichun Chen |
| author_sort | Liqiang Su |
| collection | DOAJ |
| description | Obesity and obesity-related diseases [type 2 diabetes, cardiovascular disease (CVD), and cancer] are becoming more common, which is a major public health concern. Metabolically healthy obesity (MHO) has become a type of obesity, accounting for a large proportion of obese people. MHO is still harmful to health. It was discovered that MHO screening criteria could not well reflect health hazards, whereas visceral fat, adiponectin pathway, oxidative stress, chronic inflammation, and histological indicators at the microlevel could clearly distinguish MHO from health control, and the biological pathways involved in these micro indicators were related to MHO pathogenesis. This review reveals that MHO’s micro metabolic abnormality is the initial cause of the increase of disease risk in the future. Exploring the biological pathway of MHO is important in order to develop an effective mechanism-based preventive and treatment intervention strategy. Exercise can correct the abnormal micro metabolic pathway of MHO, regulate metabolic homeostasis, and enhance metabolic flexibility. It is a supplementary or possible alternative to the traditional healthcare prevention/treatment strategy as well as an important strategy for reducing MHO-related health hazards. |
| first_indexed | 2024-04-12T08:55:31Z |
| format | Article |
| id | doaj.art-dffa7c6a16154264b4ef8e836f1f2b80 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-12T08:55:31Z |
| publishDate | 2022-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-dffa7c6a16154264b4ef8e836f1f2b802022-12-22T03:39:24ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2022-07-011310.3389/fphys.2022.924649924649The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health PromotionLiqiang Su0Yihe Pan1Haichun Chen2Physical Education of College, Jiangxi Normal University, Nanchang, ChinaPhysical Education of College, Jiangxi Normal University, Nanchang, ChinaSchool of Physical Education and Sport Science, Fujian Normal University, Fuzhou, ChinaObesity and obesity-related diseases [type 2 diabetes, cardiovascular disease (CVD), and cancer] are becoming more common, which is a major public health concern. Metabolically healthy obesity (MHO) has become a type of obesity, accounting for a large proportion of obese people. MHO is still harmful to health. It was discovered that MHO screening criteria could not well reflect health hazards, whereas visceral fat, adiponectin pathway, oxidative stress, chronic inflammation, and histological indicators at the microlevel could clearly distinguish MHO from health control, and the biological pathways involved in these micro indicators were related to MHO pathogenesis. This review reveals that MHO’s micro metabolic abnormality is the initial cause of the increase of disease risk in the future. Exploring the biological pathway of MHO is important in order to develop an effective mechanism-based preventive and treatment intervention strategy. Exercise can correct the abnormal micro metabolic pathway of MHO, regulate metabolic homeostasis, and enhance metabolic flexibility. It is a supplementary or possible alternative to the traditional healthcare prevention/treatment strategy as well as an important strategy for reducing MHO-related health hazards.https://www.frontiersin.org/articles/10.3389/fphys.2022.924649/fullmetabolically healthy Obesehealth Evaluationmetabolic Characteristicsdisease Riskexercise |
| spellingShingle | Liqiang Su Yihe Pan Haichun Chen The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion Frontiers in Physiology metabolically healthy Obese health Evaluation metabolic Characteristics disease Risk exercise |
| title | The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion |
| title_full | The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion |
| title_fullStr | The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion |
| title_full_unstemmed | The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion |
| title_short | The Harm of Metabolically Healthy Obese and the Effect of Exercise on Their Health Promotion |
| title_sort | harm of metabolically healthy obese and the effect of exercise on their health promotion |
| topic | metabolically healthy Obese health Evaluation metabolic Characteristics disease Risk exercise |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2022.924649/full |
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