Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Co-expression of YAP and TAZ associates with chromosomal instability in human cholangiocarcinoma

Abstract Background Activation of the oncogene yes-associated protein (YAP) is frequently detected in intrahepatic cholangiocarcinoma (iCCA); however, the expression pattern and the functional impact of its paralogue WW domain-containing transcription regulator 1 (WWTR1; synonym: TAZ) are not well d...

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Main Authors: Marcell Tóth, Lilija Wehling, Lena Thiess, Fabian Rose, Jennifer Schmitt, Sofia M. E. Weiler, Carsten Sticht, Carolina De La Torre, Melina Rausch, Thomas Albrecht, Niels Grabe, Lea Duwe, Jesper B. Andersen, Bruno C. Köhler, Christoph Springfeld, Arianeb Mehrabi, Yakup Kulu, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert, Kai Breuhahn
Format: Article
Language:English
Published: BMC 2021-10-01
Series:BMC Cancer
Subjects:
Hippo pathway
CIN25
Liver cancer
Cell density
Genomic instability
Online Access:https://doi.org/10.1186/s12885-021-08794-5

Internet

https://doi.org/10.1186/s12885-021-08794-5

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