Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice

Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice

Abstract Phosphatidylcholine transfer protein (PC-TP; synonym StarD2) is a soluble lipid-binding protein that transports phosphatidylcholine (PC) between cellular membranes. To better understand the protective metabolic effects associated with hepatic PC-TP, we generated a hepatocyte-specific PC-TP...

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Bibliographic Details
Main Authors: Samuel A. Druzak, Matteo Tardelli, Suzanne G. Mays, Mireille El Bejjani, Xulie Mo, Kristal M. Maner-Smith, Thomas Bowen, Michael L. Cato, Matthew C. Tillman, Akiko Sugiyama, Yang Xie, Haian Fu, David E. Cohen, Eric A. Ortlund
Format: Article
Language:English
Published: Nature Portfolio 2023-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-38010-w

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