Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes
Uterine Arteriovenous Malformation (UAVM) is a rare but life-threating cause of uterine bleeding. The clinical management of this condition is challenging, and there is a need to describe the most adequate approach for these patients. Uterine artery embolization (UAE) is the most widely-published tr...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-07-01
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| Series: | Journal of Personalized Medicine |
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| Online Access: | https://www.mdpi.com/2075-4426/12/7/1098 |
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| author | Francisco Javier Ruiz Labarta María Pilar Pintado Recarte Manuel González Leyte Coral Bravo Arribas Arturo Álvarez Luque Yolanda Cuñarro López Cielo García-Montero Oscar Fraile-Martinez Miguel A. Ortega Juan A. De León-Luis |
| author_facet | Francisco Javier Ruiz Labarta María Pilar Pintado Recarte Manuel González Leyte Coral Bravo Arribas Arturo Álvarez Luque Yolanda Cuñarro López Cielo García-Montero Oscar Fraile-Martinez Miguel A. Ortega Juan A. De León-Luis |
| author_sort | Francisco Javier Ruiz Labarta |
| collection | DOAJ |
| description | Uterine Arteriovenous Malformation (UAVM) is a rare but life-threating cause of uterine bleeding. The clinical management of this condition is challenging, and there is a need to describe the most adequate approach for these patients. Uterine artery embolization (UAE) is the most widely-published treatment in the literature in recent years, although there is a need to update the evidence on this treatment and to compare it with other available therapies. Thus, the objective of this systematic review is to quantify the efficacy of UAE of UAVM. In addition, we evaluated the clinical context of the patients included, the treatment complications, and the pregnancy outcomes after UAE. With this goal in mind, we finally included 371 patients spread over all continents who were included in 95 studies. Our results show that, similar to other medical therapies, the global success rate after embolization treatment was 88.4%, presenting a low risk of adverse outcomes (1.8%), even in women with later pregnancy (77% had no complications). To date, this is the largest systematic review conducted in this field, although there are still some points to address in future studies. The results obtained in our study should be outlined in UAE protocols and guidelines to aid in clinical decision-making in patients with UAVM. |
| first_indexed | 2024-03-09T10:16:49Z |
| format | Article |
| id | doaj.art-dffd37a101514d3d9605649da82ef8fd |
| institution | Directory Open Access Journal |
| issn | 2075-4426 |
| language | English |
| last_indexed | 2024-03-09T10:16:49Z |
| publishDate | 2022-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Personalized Medicine |
| spelling | doaj.art-dffd37a101514d3d9605649da82ef8fd2023-12-01T22:20:39ZengMDPI AGJournal of Personalized Medicine2075-44262022-07-01127109810.3390/jpm12071098Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy OutcomesFrancisco Javier Ruiz Labarta0María Pilar Pintado Recarte1Manuel González Leyte2Coral Bravo Arribas3Arturo Álvarez Luque4Yolanda Cuñarro López5Cielo García-Montero6Oscar Fraile-Martinez7Miguel A. Ortega8Juan A. De León-Luis9Department of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainGroup of Pathophysiology in Women, Pregnancy, Labor, and Puerperium, Health Research Institute Gregorio Marañón, 28040 Madrid, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainGroup of Pathophysiology in Women, Pregnancy, Labor, and Puerperium, Health Research Institute Gregorio Marañón, 28040 Madrid, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Medicine and Medical Specialities, Faculty of Medicine and Health Sciences, University of Alcalá, 28801 Alcala de Henares, SpainDepartment of Public and Maternal and Child Health, School of Medicine, Complutense University of Madrid, 28040 Madrid, SpainUterine Arteriovenous Malformation (UAVM) is a rare but life-threating cause of uterine bleeding. The clinical management of this condition is challenging, and there is a need to describe the most adequate approach for these patients. Uterine artery embolization (UAE) is the most widely-published treatment in the literature in recent years, although there is a need to update the evidence on this treatment and to compare it with other available therapies. Thus, the objective of this systematic review is to quantify the efficacy of UAE of UAVM. In addition, we evaluated the clinical context of the patients included, the treatment complications, and the pregnancy outcomes after UAE. With this goal in mind, we finally included 371 patients spread over all continents who were included in 95 studies. Our results show that, similar to other medical therapies, the global success rate after embolization treatment was 88.4%, presenting a low risk of adverse outcomes (1.8%), even in women with later pregnancy (77% had no complications). To date, this is the largest systematic review conducted in this field, although there are still some points to address in future studies. The results obtained in our study should be outlined in UAE protocols and guidelines to aid in clinical decision-making in patients with UAVM.https://www.mdpi.com/2075-4426/12/7/1098Uterine Arteriovenous Malformation (UAVM)hemorrhageuterine artery embolization (UAE)systematic review |
| spellingShingle | Francisco Javier Ruiz Labarta María Pilar Pintado Recarte Manuel González Leyte Coral Bravo Arribas Arturo Álvarez Luque Yolanda Cuñarro López Cielo García-Montero Oscar Fraile-Martinez Miguel A. Ortega Juan A. De León-Luis Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes Journal of Personalized Medicine Uterine Arteriovenous Malformation (UAVM) hemorrhage uterine artery embolization (UAE) systematic review |
| title | Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes |
| title_full | Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes |
| title_fullStr | Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes |
| title_full_unstemmed | Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes |
| title_short | Uterine Artery Embolization of Uterine Arteriovenous Malformation: A Systematic Review of Success Rate, Complications, and Posterior Pregnancy Outcomes |
| title_sort | uterine artery embolization of uterine arteriovenous malformation a systematic review of success rate complications and posterior pregnancy outcomes |
| topic | Uterine Arteriovenous Malformation (UAVM) hemorrhage uterine artery embolization (UAE) systematic review |
| url | https://www.mdpi.com/2075-4426/12/7/1098 |
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