Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder
Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disease featuring executive control deficits as a prominent neuropsychological trait. Executive functions are implicated in multiple sub-networks of the brain; however, few studies examine these sub-networks as a whole in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-11-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00246/full |
| _version_ | 1811280433012277248 |
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| author | Jiejie Tao Xueyan Jiang Xueyan Jiang Xin Wang Huiru Liu Andan Qian Chuang Yang Hong Chen Jiance Li Qiong Ye Jinhui Wang Jinhui Wang Meihao Wang |
| author_facet | Jiejie Tao Xueyan Jiang Xueyan Jiang Xin Wang Huiru Liu Andan Qian Chuang Yang Hong Chen Jiance Li Qiong Ye Jinhui Wang Jinhui Wang Meihao Wang |
| author_sort | Jiejie Tao |
| collection | DOAJ |
| description | Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disease featuring executive control deficits as a prominent neuropsychological trait. Executive functions are implicated in multiple sub-networks of the brain; however, few studies examine these sub-networks as a whole in ADHD. By combining resting-state functional MRI and graph-based approaches, we systematically investigated functional connectivity patterns among four control-related networks, including the frontoparietal network (FPN), cingulo-opercular network, cerebellar network, and default mode network (DMN), in 46 drug-naive children with ADHD and 31 age-, gender-, and intelligence quotient-matched healthy controls (HCs). Compared to the HCs, the ADHD children showed significantly decreased functional connectivity that primarily involved the DMN and FPN regions and cross-network long-range connections. Further graph-based network analysis revealed that the ADHD children had fewer connections, lower network efficiency, and more functional modules compared with the HCs. The ADHD-related alterations in functional connectivity but not topological organization were correlated with clinical symptoms of the ADHD children and differentiated the patients from the HCs with a good performance. Taken together, our findings suggest a less-integrated functional brain network in children with ADHD due to selective disruption of key long-range connections, with important implications for understanding the neural substrates of ADHD, particularly executive dysfunction. |
| first_indexed | 2024-04-13T01:14:53Z |
| format | Article |
| id | doaj.art-dffd7446246d40c7ba602d370c14e913 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-04-13T01:14:53Z |
| publishDate | 2017-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-dffd7446246d40c7ba602d370c14e9132022-12-22T03:09:00ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402017-11-01810.3389/fpsyt.2017.00246223689Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity DisorderJiejie Tao0Xueyan Jiang1Xueyan Jiang2Xin Wang3Huiru Liu4Andan Qian5Chuang Yang6Hong Chen7Jiance Li8Qiong Ye9Jinhui Wang10Jinhui Wang11Meihao Wang12Department of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaCenter for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, ChinaDepartment of Radiology, Yancheng First Peoples’ Hospital, Yancheng, ChinaDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaDepartment of Psychiatry, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaDepartment of Psychiatry, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaCenter for Cognition and Brain Disorders, Hangzhou Normal University, Hangzhou, ChinaZhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou, ChinaDepartment of Radiology, First Affiliated Hospital of Wenzhou Medical University, Wenzhou Medical University, Wenzhou, ChinaAttention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disease featuring executive control deficits as a prominent neuropsychological trait. Executive functions are implicated in multiple sub-networks of the brain; however, few studies examine these sub-networks as a whole in ADHD. By combining resting-state functional MRI and graph-based approaches, we systematically investigated functional connectivity patterns among four control-related networks, including the frontoparietal network (FPN), cingulo-opercular network, cerebellar network, and default mode network (DMN), in 46 drug-naive children with ADHD and 31 age-, gender-, and intelligence quotient-matched healthy controls (HCs). Compared to the HCs, the ADHD children showed significantly decreased functional connectivity that primarily involved the DMN and FPN regions and cross-network long-range connections. Further graph-based network analysis revealed that the ADHD children had fewer connections, lower network efficiency, and more functional modules compared with the HCs. The ADHD-related alterations in functional connectivity but not topological organization were correlated with clinical symptoms of the ADHD children and differentiated the patients from the HCs with a good performance. Taken together, our findings suggest a less-integrated functional brain network in children with ADHD due to selective disruption of key long-range connections, with important implications for understanding the neural substrates of ADHD, particularly executive dysfunction.http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00246/fullbrain networkexecutive controlgraph theorylong-range connectivityresting-state fMRI |
| spellingShingle | Jiejie Tao Xueyan Jiang Xueyan Jiang Xin Wang Huiru Liu Andan Qian Chuang Yang Hong Chen Jiance Li Qiong Ye Jinhui Wang Jinhui Wang Meihao Wang Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder Frontiers in Psychiatry brain network executive control graph theory long-range connectivity resting-state fMRI |
| title | Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder |
| title_full | Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder |
| title_fullStr | Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder |
| title_full_unstemmed | Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder |
| title_short | Disrupted Control-Related Functional Brain Networks in Drug-Naive Children with Attention-Deficit/Hyperactivity Disorder |
| title_sort | disrupted control related functional brain networks in drug naive children with attention deficit hyperactivity disorder |
| topic | brain network executive control graph theory long-range connectivity resting-state fMRI |
| url | http://journal.frontiersin.org/article/10.3389/fpsyt.2017.00246/full |
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