The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy
Background: Electroconvulsive therapy (ECT) is a medical treatment used in serious mental illnesses, in which a small amount of electricity passed the brain. The hemodynamic side effects include an initial parasympathetic response causing transient bradycardia, followed by a sympathetic discharge re...
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Isfahan University of Medical Sciences
2013-12-01
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| Series: | مجله دانشکده پزشکی اصفهان |
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| Online Access: | http://jims.mui.ac.ir/index.php/jims/article/view/1488 |
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| author | Azim Honarmand Seyyed-Mohammadreza Safavi Mehrdad Salehi Mohammadreza Habibzadeh Mehrdad Masoudifar Masoud Nazem Fahimeh Mehdizadeh Shahnaz Barvarz |
| author_facet | Azim Honarmand Seyyed-Mohammadreza Safavi Mehrdad Salehi Mohammadreza Habibzadeh Mehrdad Masoudifar Masoud Nazem Fahimeh Mehdizadeh Shahnaz Barvarz |
| author_sort | Azim Honarmand |
| collection | DOAJ |
| description | Background: Electroconvulsive therapy (ECT) is a medical treatment used in serious mental illnesses, in which a small amount of electricity passed the brain. The hemodynamic side effects include an initial parasympathetic response causing transient bradycardia, followed by a sympathetic discharge resulting in tachycardia, hypertension and a risk of arrhythmias. The aim of this study was to determine the effect of different doses of magnesium sulfate on cardiovascular response after electroconvulsive therapy.
Methods: This clinical-trial, double-blind, randomized study was held cross over on 35 patients in electroconvulsive therapy (ECT) center of Noor hospital in Isfahan, Iran, in 2011. Each patient was randomly assigned to be allocated twice into each of the four test groups which received placebo (control) or 10 (second), 20 (third), or 30 (forth) mg/kg of MgSo4. Systolic and diastolic arterial blood pressures, heart rate and oxygen saturation values were recorded on arrival for the ECT and then at 0, 1, 3 and 10 minutes after the end of the ECT-induced seizure.
Findings: Mean systolic blood pressure at 0, 1 and 3 minutes after the end of the ECT-induced seizure of the second (126.140 ± 20.937, 122.710 ,± 18.524, and 115.710 ± 17.504 mmHg, respectively) and third (123.000 ± 18.077, 123.710 ± 14.770, and 116.290 ± 14.201 mmHg, respectively) groups were statistically different compared to controls. Besides, mean diastolic blood pressure at 0, 1 and 3 minutes after the end of the ECT-induced seizure of the second group (76.000 ± 10.304, 74.430 ± 9.669, and 76.140 ± 9.082 mmHg, respectively) were statistically different compared to control group. Mean arterial blood pressure (MAP) at 0, 1 and 3 minutes after the end of the ECT of the second (92.140 ± 12.237, 90.710 ± 12.328, and 89.330 ± 12.425 mmHg, respectively) and third (91.670 ± 11.602, 90.860 ± 10.905, 89.520 ± 9.873 mmHg, respectively) groups compared with the control group were statistically different, too. Heart rate and arterial oxygen saturation at different times in the four groups were not statistically different.
Conclusion: Based on the results of this study, magnesium sulfate with doses of 20 and 30 mg/kg attenuated the systolic and diastolic blood pressure and mean arterial blood pressure (MAP) response of electroconvulsive therapy without reducing the duration of seizure activity. |
| first_indexed | 2024-03-12T09:29:40Z |
| format | Article |
| id | doaj.art-dfff841adc1b43b881df8916d2149a17 |
| institution | Directory Open Access Journal |
| issn | 1027-7595 1735-854X |
| language | fas |
| last_indexed | 2024-03-12T09:29:40Z |
| publishDate | 2013-12-01 |
| publisher | Isfahan University of Medical Sciences |
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| series | مجله دانشکده پزشکی اصفهان |
| spelling | doaj.art-dfff841adc1b43b881df8916d2149a172023-09-02T13:56:59ZfasIsfahan University of Medical Sciencesمجله دانشکده پزشکی اصفهان1027-75951735-854X2013-12-0131255156915781431The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive TherapyAzim Honarmand0Seyyed-Mohammadreza Safavi1Mehrdad Salehi2Mohammadreza Habibzadeh3Mehrdad Masoudifar4Masoud Nazem5Fahimeh Mehdizadeh6Shahnaz Barvarz7Associate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Behavioral Sciences Research Center AND Department of Psychiatric Medicine, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranFellowship in Critical Care Unit, Department of Anesthesiology, Imam Hussein Hospital, Isfahan University of Medical Sciences, Isfahan, IranAssistant Professor, Department of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranAssociate Professor, Department of Surgery, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranStudent of Medicine, School of Medicine AND Student Research Committee, Isfahan University of Medical Sciences, Isfahan, IranDepartment of Anesthesiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranBackground: Electroconvulsive therapy (ECT) is a medical treatment used in serious mental illnesses, in which a small amount of electricity passed the brain. The hemodynamic side effects include an initial parasympathetic response causing transient bradycardia, followed by a sympathetic discharge resulting in tachycardia, hypertension and a risk of arrhythmias. The aim of this study was to determine the effect of different doses of magnesium sulfate on cardiovascular response after electroconvulsive therapy. Methods: This clinical-trial, double-blind, randomized study was held cross over on 35 patients in electroconvulsive therapy (ECT) center of Noor hospital in Isfahan, Iran, in 2011. Each patient was randomly assigned to be allocated twice into each of the four test groups which received placebo (control) or 10 (second), 20 (third), or 30 (forth) mg/kg of MgSo4. Systolic and diastolic arterial blood pressures, heart rate and oxygen saturation values were recorded on arrival for the ECT and then at 0, 1, 3 and 10 minutes after the end of the ECT-induced seizure. Findings: Mean systolic blood pressure at 0, 1 and 3 minutes after the end of the ECT-induced seizure of the second (126.140 ± 20.937, 122.710 ,± 18.524, and 115.710 ± 17.504 mmHg, respectively) and third (123.000 ± 18.077, 123.710 ± 14.770, and 116.290 ± 14.201 mmHg, respectively) groups were statistically different compared to controls. Besides, mean diastolic blood pressure at 0, 1 and 3 minutes after the end of the ECT-induced seizure of the second group (76.000 ± 10.304, 74.430 ± 9.669, and 76.140 ± 9.082 mmHg, respectively) were statistically different compared to control group. Mean arterial blood pressure (MAP) at 0, 1 and 3 minutes after the end of the ECT of the second (92.140 ± 12.237, 90.710 ± 12.328, and 89.330 ± 12.425 mmHg, respectively) and third (91.670 ± 11.602, 90.860 ± 10.905, 89.520 ± 9.873 mmHg, respectively) groups compared with the control group were statistically different, too. Heart rate and arterial oxygen saturation at different times in the four groups were not statistically different. Conclusion: Based on the results of this study, magnesium sulfate with doses of 20 and 30 mg/kg attenuated the systolic and diastolic blood pressure and mean arterial blood pressure (MAP) response of electroconvulsive therapy without reducing the duration of seizure activity.http://jims.mui.ac.ir/index.php/jims/article/view/1488Magnesium sulfateCardiovascular responseElectroconvulsive therapy (ECT) |
| spellingShingle | Azim Honarmand Seyyed-Mohammadreza Safavi Mehrdad Salehi Mohammadreza Habibzadeh Mehrdad Masoudifar Masoud Nazem Fahimeh Mehdizadeh Shahnaz Barvarz The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy مجله دانشکده پزشکی اصفهان Magnesium sulfate Cardiovascular response Electroconvulsive therapy (ECT) |
| title | The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy |
| title_full | The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy |
| title_fullStr | The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy |
| title_full_unstemmed | The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy |
| title_short | The Effect of Magnesium Sulfate on Blood Pressure and Heart Rate after Electroconvulsive Therapy |
| title_sort | effect of magnesium sulfate on blood pressure and heart rate after electroconvulsive therapy |
| topic | Magnesium sulfate Cardiovascular response Electroconvulsive therapy (ECT) |
| url | http://jims.mui.ac.ir/index.php/jims/article/view/1488 |
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