Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression
With the rapid development of biomedicine, a series of studies have shown that there is a close relationship between depression and intestinal microorganisms. Patients with depression are usually accompanied by changes in the species, relative abundance and metabolites of intestinal microflora. Shor...
| Main Authors: | , , |
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| Format: | Article |
| Language: | zho |
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The editorial department of Science and Technology of Food Industry
2022-04-01
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| Series: | Shipin gongye ke-ji |
| Subjects: | |
| Online Access: | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021030387 |
| _version_ | 1797983583429722112 |
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| author | Lufen YE Xujiao SONG Hao MA |
| author_facet | Lufen YE Xujiao SONG Hao MA |
| author_sort | Lufen YE |
| collection | DOAJ |
| description | With the rapid development of biomedicine, a series of studies have shown that there is a close relationship between depression and intestinal microorganisms. Patients with depression are usually accompanied by changes in the species, relative abundance and metabolites of intestinal microflora. Short-chain fatty acids, the metabolites of intestinal flora, are important mediators that connect the host and intestinal flora. They have biological effects and affect the physiological function of the host. In recent years, the prevention and treatment of depression based on short-chain fatty acids has been a hot topic in this field. The content of short-chain fatty acids in the intestinal tract affects the occurrence and development of depression. This article mainly reviews the possible mechanisms of SCFA on depression (regulating hypothalamus-pituitary-adrenal axis, affecting tryptophan metabolism and reducing inflammation) and the possible ways of exogenous intervention in the treatment of depression (edible probiotics, probiotics and fecal flora transplantation), in order to provide theoretical reference for the development of new depression treatment drugs. |
| first_indexed | 2024-04-11T06:49:38Z |
| format | Article |
| id | doaj.art-e000e7b36d7147dfaf2bbe6bff0439eb |
| institution | Directory Open Access Journal |
| issn | 1002-0306 |
| language | zho |
| last_indexed | 2024-04-11T06:49:38Z |
| publishDate | 2022-04-01 |
| publisher | The editorial department of Science and Technology of Food Industry |
| record_format | Article |
| series | Shipin gongye ke-ji |
| spelling | doaj.art-e000e7b36d7147dfaf2bbe6bff0439eb2022-12-22T04:39:15ZzhoThe editorial department of Science and Technology of Food IndustryShipin gongye ke-ji1002-03062022-04-0143742442910.13386/j.issn1002-0306.20210303872021030387-7Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and DepressionLufen YE0Xujiao SONG1Hao MA2College of Chemistry and Biological Engineering, Yichun University, Yichun 336000, ChinaCollege of Chemistry and Biological Engineering, Yichun University, Yichun 336000, ChinaAesthetic Medical School, Yichun University, Yichun 336000, ChinaWith the rapid development of biomedicine, a series of studies have shown that there is a close relationship between depression and intestinal microorganisms. Patients with depression are usually accompanied by changes in the species, relative abundance and metabolites of intestinal microflora. Short-chain fatty acids, the metabolites of intestinal flora, are important mediators that connect the host and intestinal flora. They have biological effects and affect the physiological function of the host. In recent years, the prevention and treatment of depression based on short-chain fatty acids has been a hot topic in this field. The content of short-chain fatty acids in the intestinal tract affects the occurrence and development of depression. This article mainly reviews the possible mechanisms of SCFA on depression (regulating hypothalamus-pituitary-adrenal axis, affecting tryptophan metabolism and reducing inflammation) and the possible ways of exogenous intervention in the treatment of depression (edible probiotics, probiotics and fecal flora transplantation), in order to provide theoretical reference for the development of new depression treatment drugs.http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021030387depressionmetabolites of intestinal florashort-chain fatty acids (scfa)hypothalamic-pituitary-adrenal axistryptophan (trp) |
| spellingShingle | Lufen YE Xujiao SONG Hao MA Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression Shipin gongye ke-ji depression metabolites of intestinal flora short-chain fatty acids (scfa) hypothalamic-pituitary-adrenal axis tryptophan (trp) |
| title | Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression |
| title_full | Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression |
| title_fullStr | Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression |
| title_full_unstemmed | Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression |
| title_short | Research Progress on the Relationship between Short-chain Fatty Acids Metabolized by Intestinal Flora and Depression |
| title_sort | research progress on the relationship between short chain fatty acids metabolized by intestinal flora and depression |
| topic | depression metabolites of intestinal flora short-chain fatty acids (scfa) hypothalamic-pituitary-adrenal axis tryptophan (trp) |
| url | http://www.spgykj.com/cn/article/doi/10.13386/j.issn1002-0306.2021030387 |
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