Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry
Association studies between ADIPOR1 genetic variants and predisposition to type 2 diabetes (DM2) have provided contradictory results. We determined if two single nucleotide polymorphisms (SNP c.-8503G>A and SNP c.10225C>G) in regulatory regions of ADIPOR1 in 567 Brazilian individuals of Europe...
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2008-06-01
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| Series: | Brazilian Journal of Medical and Biological Research |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600005 |
| _version_ | 1818062623079399424 |
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| author | E. Yeh L. Kimura F.I.V. Errera C.B. Angeli R.C. Mingroni-Netto M.E.R. Silva L.H.S. Canani M.R. Passos-Bueno |
| author_facet | E. Yeh L. Kimura F.I.V. Errera C.B. Angeli R.C. Mingroni-Netto M.E.R. Silva L.H.S. Canani M.R. Passos-Bueno |
| author_sort | E. Yeh |
| collection | DOAJ |
| description | Association studies between ADIPOR1 genetic variants and predisposition to type 2 diabetes (DM2) have provided contradictory results. We determined if two single nucleotide polymorphisms (SNP c.-8503G>A and SNP c.10225C>G) in regulatory regions of ADIPOR1 in 567 Brazilian individuals of European (EA; N = 443) or African (AfA; N = 124) ancestry from rural (quilombo remnants; N = 439) and urban (N = 567) areas. We detected a significant effect of ethnicity on the distribution of the allelic frequencies of both SNPs in these populations (EA: -8503A = 0.27; AfA: -8503A = 0.16; P = 0.001 and EA: 10225G = 0.35; AfA: 10225G = 0.51; P < 0.001). Neither of the polymorphisms were associated with DM2 in the case-control study in EA (SNP c.-8503G>A: DM2 group -8503A = 0.26; control group -8503A = 0.30; P = 0.14/SNP 10225C>G: DM2 group 10225G = 0.37; control group 10225G = 0.32; P = 0.40) and AfA populations (SNP c.-8503G>A: DM2 group -8503A = 0.16; control group -8503A = 0.15; P = 0.34/SNP 10225C>G: DM2 group 10225G = 0.51; control group 10225G = 0.52; P = 0.50). Similarly, none of the polymorphisms were associated with metabolic/anthropometric risk factors for DM2 in any of the three populations, except for HDL cholesterol, which was significantly higher in AfA heterozygotes (GC = 53.75 ± 17.26 mg/dL) than in homozygotes. We conclude that ADIPOR1 polymorphisms are unlikely to be major risk factors for DM2 or for metabolic/anthropometric measurements that represent risk factors for DM2 in populations of European and African ancestries. |
| first_indexed | 2024-12-10T14:07:09Z |
| format | Article |
| id | doaj.art-e0012a8a6fda41428d433d3efea68c2b |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-10T14:07:09Z |
| publishDate | 2008-06-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-e0012a8a6fda41428d433d3efea68c2b2022-12-22T01:45:38ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2008-06-01416468472Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestryE. YehL. KimuraF.I.V. ErreraC.B. AngeliR.C. Mingroni-NettoM.E.R. SilvaL.H.S. CananiM.R. Passos-BuenoAssociation studies between ADIPOR1 genetic variants and predisposition to type 2 diabetes (DM2) have provided contradictory results. We determined if two single nucleotide polymorphisms (SNP c.-8503G>A and SNP c.10225C>G) in regulatory regions of ADIPOR1 in 567 Brazilian individuals of European (EA; N = 443) or African (AfA; N = 124) ancestry from rural (quilombo remnants; N = 439) and urban (N = 567) areas. We detected a significant effect of ethnicity on the distribution of the allelic frequencies of both SNPs in these populations (EA: -8503A = 0.27; AfA: -8503A = 0.16; P = 0.001 and EA: 10225G = 0.35; AfA: 10225G = 0.51; P < 0.001). Neither of the polymorphisms were associated with DM2 in the case-control study in EA (SNP c.-8503G>A: DM2 group -8503A = 0.26; control group -8503A = 0.30; P = 0.14/SNP 10225C>G: DM2 group 10225G = 0.37; control group 10225G = 0.32; P = 0.40) and AfA populations (SNP c.-8503G>A: DM2 group -8503A = 0.16; control group -8503A = 0.15; P = 0.34/SNP 10225C>G: DM2 group 10225G = 0.51; control group 10225G = 0.52; P = 0.50). Similarly, none of the polymorphisms were associated with metabolic/anthropometric risk factors for DM2 in any of the three populations, except for HDL cholesterol, which was significantly higher in AfA heterozygotes (GC = 53.75 ± 17.26 mg/dL) than in homozygotes. We conclude that ADIPOR1 polymorphisms are unlikely to be major risk factors for DM2 or for metabolic/anthropometric measurements that represent risk factors for DM2 in populations of European and African ancestries.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600005Association studyAdiponectin receptorsType 2 diabetesPolymorphism for ancestry-admixture mappingHDL cholesterolAssociation of ADIPOR1 with DM2 |
| spellingShingle | E. Yeh L. Kimura F.I.V. Errera C.B. Angeli R.C. Mingroni-Netto M.E.R. Silva L.H.S. Canani M.R. Passos-Bueno Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry Brazilian Journal of Medical and Biological Research Association study Adiponectin receptors Type 2 diabetes Polymorphism for ancestry-admixture mapping HDL cholesterol Association of ADIPOR1 with DM2 |
| title | Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry |
| title_full | Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry |
| title_fullStr | Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry |
| title_full_unstemmed | Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry |
| title_short | Association of polymorphisms at the ADIPOR1 regulatory region with type 2 diabetes and body mass index in a Brazilian population with European or African ancestry |
| title_sort | association of polymorphisms at the adipor1 regulatory region with type 2 diabetes and body mass index in a brazilian population with european or african ancestry |
| topic | Association study Adiponectin receptors Type 2 diabetes Polymorphism for ancestry-admixture mapping HDL cholesterol Association of ADIPOR1 with DM2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2008000600005 |
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