Progress of Nanomaterials in Photodynamic Therapy Against Tumor
Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the thre...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-05-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2022.920162/full |
| _version_ | 1811254891132223488 |
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| author | Lei Chen Jiahui Huang Xiaotong Li Miaoting Huang Shaoting Zeng Jiayi Zheng Shuyi Peng Shiying Li |
| author_facet | Lei Chen Jiahui Huang Xiaotong Li Miaoting Huang Shaoting Zeng Jiayi Zheng Shuyi Peng Shiying Li |
| author_sort | Lei Chen |
| collection | DOAJ |
| description | Photodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor. |
| first_indexed | 2024-04-12T17:15:25Z |
| format | Article |
| id | doaj.art-e001484c8ef543cabef52f143f91e37a |
| institution | Directory Open Access Journal |
| issn | 2296-4185 |
| language | English |
| last_indexed | 2024-04-12T17:15:25Z |
| publishDate | 2022-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj.art-e001484c8ef543cabef52f143f91e37a2022-12-22T03:23:41ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852022-05-011010.3389/fbioe.2022.920162920162Progress of Nanomaterials in Photodynamic Therapy Against TumorLei Chen0Jiahui Huang1Xiaotong Li2Miaoting Huang3Shaoting Zeng4Jiayi Zheng5Shuyi Peng6Shiying Li7Department of Anesthesiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, ChinaDepartment of Anesthesiology, Huizhou Central People’s Hospital, Huizhou, ChinaGuangzhou Medical University, Guangzhou, ChinaGuangzhou Medical University, Guangzhou, ChinaGuangzhou Medical University, Guangzhou, ChinaGuangzhou Medical University, Guangzhou, ChinaGuangzhou Medical University, Guangzhou, ChinaKey Laboratory of Molecular Target and Clinical Pharmacology and The State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, ChinaPhotodynamic therapy (PDT) is an advanced therapeutic strategy with light-triggered, minimally invasive, high spatiotemporal selective and low systemic toxicity properties, which has been widely used in the clinical treatment of many solid tumors in recent years. Any strategies that improve the three elements of PDT (light, oxygen, and photosensitizers) can improve the efficacy of PDT. However, traditional PDT is confronted some challenges of poor solubility of photosensitizers and tumor suppressive microenvironment. To overcome the related obstacles of PDT, various strategies have been investigated in terms of improving photosensitizers (PSs) delivery, penetration of excitation light sources, and hypoxic tumor microenvironment. In addition, compared with a single treatment mode, the synergistic treatment of multiple treatment modalities such as photothermal therapy, chemotherapy, and radiation therapy can improve the efficacy of PDT. This review summarizes recent advances in nanomaterials, including metal nanoparticles, liposomes, hydrogels and polymers, to enhance the efficiency of PDT against malignant tumor.https://www.frontiersin.org/articles/10.3389/fbioe.2022.920162/fullphotodynamic therapytumor microenvironmentnanomaterialstumor-targetingphotosensitizers |
| spellingShingle | Lei Chen Jiahui Huang Xiaotong Li Miaoting Huang Shaoting Zeng Jiayi Zheng Shuyi Peng Shiying Li Progress of Nanomaterials in Photodynamic Therapy Against Tumor Frontiers in Bioengineering and Biotechnology photodynamic therapy tumor microenvironment nanomaterials tumor-targeting photosensitizers |
| title | Progress of Nanomaterials in Photodynamic Therapy Against Tumor |
| title_full | Progress of Nanomaterials in Photodynamic Therapy Against Tumor |
| title_fullStr | Progress of Nanomaterials in Photodynamic Therapy Against Tumor |
| title_full_unstemmed | Progress of Nanomaterials in Photodynamic Therapy Against Tumor |
| title_short | Progress of Nanomaterials in Photodynamic Therapy Against Tumor |
| title_sort | progress of nanomaterials in photodynamic therapy against tumor |
| topic | photodynamic therapy tumor microenvironment nanomaterials tumor-targeting photosensitizers |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2022.920162/full |
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