Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co‐Occurrence of P63A and P380S BAG3 Variants

Dysregulated Autophagy and Sarcomere Dysfunction in Patients With Heart Failure With Co‐Occurrence of P63A and P380S BAG3 Variants

Background Mutations to the co‐chaperone protein BAG3 (B‐cell lymphoma‐2–associated athanogene‐3) are a leading cause of dilated cardiomyopathy (DCM). These mutations often impact the C‐terminal BAG domain (residues 420–499), which regulates heat shock protein 70‐dependent protein turnover via autop...

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Bibliographic Details
Main Authors: Thomas G. Martin, Hana Pak, Glenn S. Gerhard, Salim Merali, Carmen Merali, Bonnie Lemster, Praveen Dubey, Charles F. McTiernan, Michael R. Bristow, Arthur M. Feldman, Jonathan A. Kirk
Format: Article
Language:English
Published: Wiley 2023-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
autophagy
BAG3
dilated cardiomyopathy
sarcomere
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.123.029938

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