Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS

Deficiency of endothelial FGFR1 signaling via upregulation of ROCK2 activity aggravated ALI/ARDS

Vascular leakage and inflammation are pathological hallmarks of acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Endothelial cells (ECs) serve as a semipermeable barrier and play a key role in disease progression. It is well known that fibroblast growth factor receptor 1 (FGFR1) i...

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Bibliographic Details
Main Authors: Yue Deng, Xingming Huang, Yan Hu, Weiting Zhong, Hua Zhang, Chunheng Mo, Hongjun Wang, Bi-Sen Ding, Chen Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
ALI/ARDS
vascular leakage
inflammation
endothelial cell
FGFR1
ROCK2
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1041533/full

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