Complement-targeted therapies in kidney transplantation—insights from preclinical studies

Complement-targeted therapies in kidney transplantation—insights from preclinical studies

Aberrant activation of the complement system contributes to solid-organ graft dysfunction and failure. In kidney transplantation, the complement system is implicated in the pathogenesis of antibody- and cell-mediated rejection, ischemia-reperfusion injury, and vascular injury. This has led to the ev...

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Bibliographic Details
Main Authors:	Imran J. Anwar, Isabel DeLaura, Joseph Ladowski, Qimeng Gao, Stuart J. Knechtle, Jean Kwun
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-10-01
Series:	Frontiers in Immunology
Subjects:	complement allotransplantation xenotransplantation animal model nonhuman primate (NHP)
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.984090/full

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