Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis
Abstract Bronchiectasis is a common feature of severe inherited and acquired pulmonary disease conditions. Among inherited diseases, cystic fibrosis (CF) is the major disorder associated with bronchiectasis, while acquired conditions frequently featuring bronchiectasis include post-infective bronchi...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-05-01
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| Series: | BMC Pulmonary Medicine |
| Online Access: | http://link.springer.com/article/10.1186/s12890-018-0630-8 |
| _version_ | 1818134644192706560 |
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| author | Jürgen Schäfer Matthias Griese Ravishankar Chandrasekaran Sanjay H. Chotirmall Dominik Hartl |
| author_facet | Jürgen Schäfer Matthias Griese Ravishankar Chandrasekaran Sanjay H. Chotirmall Dominik Hartl |
| author_sort | Jürgen Schäfer |
| collection | DOAJ |
| description | Abstract Bronchiectasis is a common feature of severe inherited and acquired pulmonary disease conditions. Among inherited diseases, cystic fibrosis (CF) is the major disorder associated with bronchiectasis, while acquired conditions frequently featuring bronchiectasis include post-infective bronchiectasis and chronic obstructive pulmonary disease (COPD). Mechanistically, bronchiectasis is driven by a complex interplay of inflammation and infection with neutrophilic inflammation playing a predominant role. The clinical characterization and management of bronchiectasis should involve a precise diagnostic workup, tailored therapeutic strategies and pulmonary imaging that has become an essential tool for the diagnosis and follow-up of bronchiectasis. Prospective future studies are required to optimize the diagnostic and therapeutic management of bronchiectasis, particularly in heterogeneous non-CF bronchiectasis populations. |
| first_indexed | 2024-12-11T09:11:53Z |
| format | Article |
| id | doaj.art-e0085c0ca1c84039bfa923f16da546e2 |
| institution | Directory Open Access Journal |
| issn | 1471-2466 |
| language | English |
| last_indexed | 2024-12-11T09:11:53Z |
| publishDate | 2018-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pulmonary Medicine |
| spelling | doaj.art-e0085c0ca1c84039bfa923f16da546e22022-12-22T01:13:28ZengBMCBMC Pulmonary Medicine1471-24662018-05-0118111110.1186/s12890-018-0630-8Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasisJürgen Schäfer0Matthias Griese1Ravishankar Chandrasekaran2Sanjay H. Chotirmall3Dominik Hartl4Department of Radiology, Division of Pediatric Radiology, University of TübingenChildren’s Hospital, University of MunichLee Kong Chian School of Medicine, Nanyang Technological UniversityLee Kong Chian School of Medicine, Nanyang Technological UniversityDepartment of Pediatrics I, University of TübingenAbstract Bronchiectasis is a common feature of severe inherited and acquired pulmonary disease conditions. Among inherited diseases, cystic fibrosis (CF) is the major disorder associated with bronchiectasis, while acquired conditions frequently featuring bronchiectasis include post-infective bronchiectasis and chronic obstructive pulmonary disease (COPD). Mechanistically, bronchiectasis is driven by a complex interplay of inflammation and infection with neutrophilic inflammation playing a predominant role. The clinical characterization and management of bronchiectasis should involve a precise diagnostic workup, tailored therapeutic strategies and pulmonary imaging that has become an essential tool for the diagnosis and follow-up of bronchiectasis. Prospective future studies are required to optimize the diagnostic and therapeutic management of bronchiectasis, particularly in heterogeneous non-CF bronchiectasis populations.http://link.springer.com/article/10.1186/s12890-018-0630-8 |
| spellingShingle | Jürgen Schäfer Matthias Griese Ravishankar Chandrasekaran Sanjay H. Chotirmall Dominik Hartl Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis BMC Pulmonary Medicine |
| title | Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis |
| title_full | Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis |
| title_fullStr | Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis |
| title_full_unstemmed | Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis |
| title_short | Pathogenesis, imaging and clinical characteristics of CF and non-CF bronchiectasis |
| title_sort | pathogenesis imaging and clinical characteristics of cf and non cf bronchiectasis |
| url | http://link.springer.com/article/10.1186/s12890-018-0630-8 |
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