The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding

The Antimicrobials Anacardic Acid and Curcumin Are Not-Competitive Inhibitors of Gram-Positive Bacterial Pathogenic Glyceraldehyde-3-Phosphate Dehydrogenase by a Mechanism Unrelated to Human C5a Anaphylatoxin Binding

The ubiquitous and highly abundant glycolytic enzyme D-glyceraldehyde-3-phosphate dehydrogenase (GAPDH) is pivotal for the energy and carbon metabolism of most organisms, including human pathogenic bacteria. For bacteria that depend mostly on glycolysis for survival, GAPDH is an attractive target fo...

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Bibliographic Details
Main Authors: Sara Gómez, Javier Querol-García, Gara Sánchez-Barrón, Marta Subias, Àlex González-Alsina, Virginia Franco-Hidalgo, Sebastián Albertí, Santiago Rodríguez de Córdoba, Francisco J. Fernández, M. Cristina Vega
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-02-01
Series:Frontiers in Microbiology
Subjects:
GAPDH – glyceraldehyde-3-phosphate dehydrogenase
Streptococcus pyogenes
Clostridium perfringens
anacardic acid
curcumin
complement – immunological term
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2019.00326/full

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