Autophagy and intermittent fasting: the connection for cancer therapy?
Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, rad...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier España
2018-12-01
|
| Series: | Clinics |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000200339&lng=en&tlng=en |
| _version_ | 1818114196590559232 |
|---|---|
| author | Fernanda Antunes Adolfo Garcia Erustes Angélica Jardim Costa Ana Carolina Nascimento Claudia Bincoletto Rodrigo Portes Ureshino Gustavo José Silva Pereira Soraya Soubhi Smaili |
| author_facet | Fernanda Antunes Adolfo Garcia Erustes Angélica Jardim Costa Ana Carolina Nascimento Claudia Bincoletto Rodrigo Portes Ureshino Gustavo José Silva Pereira Soraya Soubhi Smaili |
| author_sort | Fernanda Antunes |
| collection | DOAJ |
| description | Cancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as autophagy) is a conserved lysosomal degradation pathway for the intracellular recycling of macromolecules and clearance of damaged organelles and misfolded proteins to ensure cellular homeostasis. Dysfunctional autophagy contributes to many diseases, including cancer. Autophagy can suppress or promote tumors depending on the developmental stage and tumor type, and modulating autophagy for cancer treatment is an interesting therapeutic approach currently under intense investigation. Nutritional restriction is a promising protocol to modulate autophagy and enhance the efficacy of anticancer therapies while protecting normal cells. Here, the description and role of autophagy in tumorigenesis will be summarized. Moreover, the possibility of using fasting as an adjuvant therapy for cancer treatment, as well as the molecular mechanisms underlying this approach, will be presented. |
| first_indexed | 2024-12-11T03:46:53Z |
| format | Article |
| id | doaj.art-e00c0d840d7d40c183b74012255cbbcd |
| institution | Directory Open Access Journal |
| issn | 1980-5322 |
| language | English |
| last_indexed | 2024-12-11T03:46:53Z |
| publishDate | 2018-12-01 |
| publisher | Elsevier España |
| record_format | Article |
| series | Clinics |
| spelling | doaj.art-e00c0d840d7d40c183b74012255cbbcd2022-12-22T01:22:00ZengElsevier EspañaClinics1980-53222018-12-0173suppl 110.6061/clinics/2018/e814sS1807-59322018000200339Autophagy and intermittent fasting: the connection for cancer therapy?Fernanda AntunesAdolfo Garcia ErustesAngélica Jardim CostaAna Carolina NascimentoClaudia BincolettoRodrigo Portes UreshinoGustavo José Silva PereiraSoraya Soubhi SmailiCancer is a leading cause of death worldwide, and its incidence is continually increasing. Although anticancer therapy has improved significantly, it still has limited efficacy for tumor eradication and is highly toxic to healthy cells. Thus, novel therapeutic strategies to improve chemotherapy, radiotherapy and targeted therapy are an important goal in cancer research. Macroautophagy (herein referred to as autophagy) is a conserved lysosomal degradation pathway for the intracellular recycling of macromolecules and clearance of damaged organelles and misfolded proteins to ensure cellular homeostasis. Dysfunctional autophagy contributes to many diseases, including cancer. Autophagy can suppress or promote tumors depending on the developmental stage and tumor type, and modulating autophagy for cancer treatment is an interesting therapeutic approach currently under intense investigation. Nutritional restriction is a promising protocol to modulate autophagy and enhance the efficacy of anticancer therapies while protecting normal cells. Here, the description and role of autophagy in tumorigenesis will be summarized. Moreover, the possibility of using fasting as an adjuvant therapy for cancer treatment, as well as the molecular mechanisms underlying this approach, will be presented.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000200339&lng=en&tlng=enApoptosisAutophagyFastingCancerTherapy |
| spellingShingle | Fernanda Antunes Adolfo Garcia Erustes Angélica Jardim Costa Ana Carolina Nascimento Claudia Bincoletto Rodrigo Portes Ureshino Gustavo José Silva Pereira Soraya Soubhi Smaili Autophagy and intermittent fasting: the connection for cancer therapy? Clinics Apoptosis Autophagy Fasting Cancer Therapy |
| title | Autophagy and intermittent fasting: the connection for cancer therapy? |
| title_full | Autophagy and intermittent fasting: the connection for cancer therapy? |
| title_fullStr | Autophagy and intermittent fasting: the connection for cancer therapy? |
| title_full_unstemmed | Autophagy and intermittent fasting: the connection for cancer therapy? |
| title_short | Autophagy and intermittent fasting: the connection for cancer therapy? |
| title_sort | autophagy and intermittent fasting the connection for cancer therapy |
| topic | Apoptosis Autophagy Fasting Cancer Therapy |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322018000200339&lng=en&tlng=en |
| work_keys_str_mv | AT fernandaantunes autophagyandintermittentfastingtheconnectionforcancertherapy AT adolfogarciaerustes autophagyandintermittentfastingtheconnectionforcancertherapy AT angelicajardimcosta autophagyandintermittentfastingtheconnectionforcancertherapy AT anacarolinanascimento autophagyandintermittentfastingtheconnectionforcancertherapy AT claudiabincoletto autophagyandintermittentfastingtheconnectionforcancertherapy AT rodrigoportesureshino autophagyandintermittentfastingtheconnectionforcancertherapy AT gustavojosesilvapereira autophagyandintermittentfastingtheconnectionforcancertherapy AT sorayasoubhismaili autophagyandintermittentfastingtheconnectionforcancertherapy |