Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma
Abstract Background Markers that can be used to evaluate the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) remain undefined. Objective This study aimed to investigate the prognostic impact of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (...
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| Format: | Article |
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BMC
2023-12-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-023-11752-y |
| _version_ | 1797376942955036672 |
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| author | Jiao Zhou Sheng Wei Xiumei Guo Yanjun Huang Yizheng Zhang Yuming Hong Xiaofang Chen Ming Lu Feng Zheng Chaohui Zheng |
| author_facet | Jiao Zhou Sheng Wei Xiumei Guo Yanjun Huang Yizheng Zhang Yuming Hong Xiaofang Chen Ming Lu Feng Zheng Chaohui Zheng |
| author_sort | Jiao Zhou |
| collection | DOAJ |
| description | Abstract Background Markers that can be used to evaluate the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) remain undefined. Objective This study aimed to investigate the prognostic impact of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in patients with HNSCC who underwent surgery-based treatment for the first time. Methods This retrospective study included patients HNSCC who underwent surgery-based treatment at our institution between January 2018 and December 2020. Specificity and sensitivity were analyzed using receiver operating characteristic (ROC) curves and the critical value was determined. Patients were divided into low and high groups according to NLR, PLR, and LMR the critical value. Log-rank and Cox proportional hazards models were used to evaluate the associations between preoperative NLR, PLR, LMR, and overall survival (OS). Results A total of 304 patients with HNSCC were included, of whom 190 (62.5%) and 114 (37.5%), 203 (66.8%) and 101 (33.2%), 98 (32.2%), and 206 (67.8%) cases were classified as low NLR and high NLR groups, low PLR and high PLR groups, and low LMR and high LMR groups, respectively. Univariate analysis showed that white blood cell count (WBC), neutrophil count (NEU), platelet count (PLT), NLR, pathologic N stage (pN stage), TNM stage and postoperative complications were significantly associated with OS (p < 0.05). Multivariate analysis showed that NEU, NLR, TNM stage and postoperative complications were independent negative prognostic factors for HNSCC (p < 0.05). Conclusion Preoperative NLR is an independent negative prognostic factor for HNSCC. Patients with an increased NLR may have a poor OS. |
| first_indexed | 2024-03-08T19:46:46Z |
| format | Article |
| id | doaj.art-e00c852b673c4916aa219c451c7e55e2 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-03-08T19:46:46Z |
| publishDate | 2023-12-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-e00c852b673c4916aa219c451c7e55e22023-12-24T12:21:36ZengBMCBMC Cancer1471-24072023-12-012311910.1186/s12885-023-11752-yCorrelation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinomaJiao Zhou0Sheng Wei1Xiumei Guo2Yanjun Huang3Yizheng Zhang4Yuming Hong5Xiaofang Chen6Ming Lu7Feng Zheng8Chaohui Zheng9Department of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of General Surgery, The Second Affiliated Hospital of Anhui Medical UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Neurosurgery, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Otolaryngology, The Second Affiliated Hospital of Fujian Medical UniversityAbstract Background Markers that can be used to evaluate the prognosis of patients with head and neck squamous cell carcinoma (HNSCC) remain undefined. Objective This study aimed to investigate the prognostic impact of preoperative neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and lymphocyte-to-monocyte ratio (LMR) in patients with HNSCC who underwent surgery-based treatment for the first time. Methods This retrospective study included patients HNSCC who underwent surgery-based treatment at our institution between January 2018 and December 2020. Specificity and sensitivity were analyzed using receiver operating characteristic (ROC) curves and the critical value was determined. Patients were divided into low and high groups according to NLR, PLR, and LMR the critical value. Log-rank and Cox proportional hazards models were used to evaluate the associations between preoperative NLR, PLR, LMR, and overall survival (OS). Results A total of 304 patients with HNSCC were included, of whom 190 (62.5%) and 114 (37.5%), 203 (66.8%) and 101 (33.2%), 98 (32.2%), and 206 (67.8%) cases were classified as low NLR and high NLR groups, low PLR and high PLR groups, and low LMR and high LMR groups, respectively. Univariate analysis showed that white blood cell count (WBC), neutrophil count (NEU), platelet count (PLT), NLR, pathologic N stage (pN stage), TNM stage and postoperative complications were significantly associated with OS (p < 0.05). Multivariate analysis showed that NEU, NLR, TNM stage and postoperative complications were independent negative prognostic factors for HNSCC (p < 0.05). Conclusion Preoperative NLR is an independent negative prognostic factor for HNSCC. Patients with an increased NLR may have a poor OS.https://doi.org/10.1186/s12885-023-11752-yHead and Neck squamous cell carcinomaNeutrophilPlateletLymphocyteMonocytePrognosis |
| spellingShingle | Jiao Zhou Sheng Wei Xiumei Guo Yanjun Huang Yizheng Zhang Yuming Hong Xiaofang Chen Ming Lu Feng Zheng Chaohui Zheng Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma BMC Cancer Head and Neck squamous cell carcinoma Neutrophil Platelet Lymphocyte Monocyte Prognosis |
| title | Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma |
| title_full | Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma |
| title_fullStr | Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma |
| title_full_unstemmed | Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma |
| title_short | Correlation between preoperative peripheral blood NLR, PLR, LMR and prognosis of patients with head and neck squamous cell carcinoma |
| title_sort | correlation between preoperative peripheral blood nlr plr lmr and prognosis of patients with head and neck squamous cell carcinoma |
| topic | Head and Neck squamous cell carcinoma Neutrophil Platelet Lymphocyte Monocyte Prognosis |
| url | https://doi.org/10.1186/s12885-023-11752-y |
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