Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study
In community studies, both attenuated psychotic symptoms (APS) and basic symptoms (BS) were more frequent but less clinically relevant in children and adolescents compared to adults. In doing so, they displayed differential age thresholds that were around age 16 for APS, around age 18 for perceptive...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-11-01
|
| Series: | Frontiers in Psychiatry |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.552175/full |
| _version_ | 1819118092497715200 |
|---|---|
| author | Helene Walger Linda A. Antonucci Alessandro Pigoni Alessandro Pigoni Rachel Upthegrove Raimo K. R. Salokangas Rebekka Lencer Katharine Chisholm Katharine Chisholm Anita Riecher-Rössler Theresa Haidl Eva Meisenzahl Marlene Rosen Stephan Ruhrmann Joseph Kambeitz Lana Kambeitz-Ilankovic Peter Falkai Anne Ruef Jarmo Hietala Christos Pantelis Stephen J. Wood Stephen J. Wood Stephen J. Wood Paolo Brambilla Alessandro Bertolino Stefan Borgwardt Nikolaos Koutsouleris Frauke Schultze-Lutter Frauke Schultze-Lutter |
| author_facet | Helene Walger Linda A. Antonucci Alessandro Pigoni Alessandro Pigoni Rachel Upthegrove Raimo K. R. Salokangas Rebekka Lencer Katharine Chisholm Katharine Chisholm Anita Riecher-Rössler Theresa Haidl Eva Meisenzahl Marlene Rosen Stephan Ruhrmann Joseph Kambeitz Lana Kambeitz-Ilankovic Peter Falkai Anne Ruef Jarmo Hietala Christos Pantelis Stephen J. Wood Stephen J. Wood Stephen J. Wood Paolo Brambilla Alessandro Bertolino Stefan Borgwardt Nikolaos Koutsouleris Frauke Schultze-Lutter Frauke Schultze-Lutter |
| author_sort | Helene Walger |
| collection | DOAJ |
| description | In community studies, both attenuated psychotic symptoms (APS) and basic symptoms (BS) were more frequent but less clinically relevant in children and adolescents compared to adults. In doing so, they displayed differential age thresholds that were around age 16 for APS, around age 18 for perceptive BS, and within the early twenties for cognitive BS. Only the age effect has previously been studied and replicated in clinical samples for APS. Thus, we examined the reported age effect on and age thresholds of 14 criteria-relevant BS in a patient sample at clinical-high risk of psychosis (N = 261, age 15–40 yrs.), recruited within the European multicenter PRONIA-study. BS and the BS criteria, “Cognitive Disturbances” (COGDIS) and “Cognitive-perceptive BS” (COPER), were assessed with the “Schizophrenia Proneness Instrument, Adult version” (SPI-A). Using logistic regressions, prevalence rates of perceptive and cognitive BS, and of COGDIS and COPER, as well as the impact of social and role functioning on the association between age and BS were studied in three age groups (15–18 years, 19–23 years, 24–40 years). Most patients (91.2%) reported any BS, 55.9% any perceptive and 87.4% any cognitive BS. Furthermore, 56.3% met COGDIS and 80.5% COPER. Not exhibiting the reported differential age thresholds, both perceptive and cognitive BS, and, at trend level only, COPER were less prevalent in the oldest age group (24–40 years); COGDIS was most frequent in the youngest group (15–18 years). Functional deficits did not better explain the association with age, particularly in perceptive BS and cognitive BS meeting the frequency requirement of BS criteria. Our findings broadly confirmed an age threshold in BS and, thus, the earlier assumed link between presence of BS and brain maturation processes. Yet, age thresholds of perceptive and cognitive BS did not differ. This lack of differential age thresholds might be due to more pronounced the brain abnormalities in this clinical sample compared to earlier community samples. These might have also shown in more frequently occurring and persistent BS that, however, also resulted from a sampling toward these, i.e., toward COGDIS. Future studies should address the neurobiological basis of CHR criteria in relation to age. |
| first_indexed | 2024-12-22T05:43:23Z |
| format | Article |
| id | doaj.art-e00cb8cd0cb244b4bb96d55f832c10ee |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-22T05:43:23Z |
| publishDate | 2020-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-e00cb8cd0cb244b4bb96d55f832c10ee2022-12-21T18:37:08ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402020-11-011110.3389/fpsyt.2020.552175552175Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA StudyHelene Walger0Linda A. Antonucci1Alessandro Pigoni2Alessandro Pigoni3Rachel Upthegrove4Raimo K. R. Salokangas5Rebekka Lencer6Katharine Chisholm7Katharine Chisholm8Anita Riecher-Rössler9Theresa Haidl10Eva Meisenzahl11Marlene Rosen12Stephan Ruhrmann13Joseph Kambeitz14Lana Kambeitz-Ilankovic15Peter Falkai16Anne Ruef17Jarmo Hietala18Christos Pantelis19Stephen J. Wood20Stephen J. Wood21Stephen J. Wood22Paolo Brambilla23Alessandro Bertolino24Stefan Borgwardt25Nikolaos Koutsouleris26Frauke Schultze-Lutter27Frauke Schultze-Lutter28Department of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, GermanyDepartment of Education, Psychology, Communication, University of Bari Aldo Moro, Bari, ItalyDepartment of Neurosciences and Mental Health, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Foundation Major Hospital Polyclinic, University of Milan, Milan, ItalyMoMiLab Research Unit, Institutions, Markets, Technologies (IMT) School for Advanced Studies Lucca, Lucca, ItalyInstitute for Mental Health, University of Birmingham, Birmingham, United KingdomDepartment of Psychiatry, Medical Faculty, University of Turku, Turku, FinlandDepartment of Psychiatry and Psychotherapy, and Otto Creutzfeldt Center for Cognitive and Behavioral Neuroscience, University of Muenster, Muenster, GermanyInstitute for Mental Health, University of Birmingham, Birmingham, United KingdomDepartment of Psychology, Aston University, Birmingham, United KingdomDepartment of Psychiatry (Psychiatric University Hospital, UPK), University of Basel, Basel, Switzerland0Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany1Department of Psychiatry and Psychotherapy, Medical Faculty, Heinrich-Heine University, Düsseldorf, Germany0Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany0Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany0Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany0Department of Psychiatry and Psychotherapy, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, GermanyDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, GermanyDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, GermanyDepartment of Psychiatry, Medical Faculty, University of Turku, Turku, Finland2Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Carlton, VIC, AustraliaInstitute for Mental Health, University of Birmingham, Birmingham, United Kingdom3Orygen, The National Centre of Excellence for Youth Mental Health, Melbourne, VIC, Australia4Centre for Youth Mental Health, University of Melbourne, Parkville, VIC, AustraliaDepartment of Neurosciences and Mental Health, Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca' Granda Foundation Major Hospital Polyclinic, University of Milan, Milan, Italy5Group of Psychiatric Neuroscience, Department of Basic Medical Science, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, ItalyDepartment of Psychiatry (Psychiatric University Hospital, UPK), University of Basel, Basel, SwitzerlandDepartment of Psychiatry and Psychotherapy, Ludwig-Maximilian-University, Munich, GermanyDepartment of Education, Psychology, Communication, University of Bari Aldo Moro, Bari, Italy6Department of Psychology and Mental Health, Faculty of Psychology, Airlangga University, Surabaya, IndonesiaIn community studies, both attenuated psychotic symptoms (APS) and basic symptoms (BS) were more frequent but less clinically relevant in children and adolescents compared to adults. In doing so, they displayed differential age thresholds that were around age 16 for APS, around age 18 for perceptive BS, and within the early twenties for cognitive BS. Only the age effect has previously been studied and replicated in clinical samples for APS. Thus, we examined the reported age effect on and age thresholds of 14 criteria-relevant BS in a patient sample at clinical-high risk of psychosis (N = 261, age 15–40 yrs.), recruited within the European multicenter PRONIA-study. BS and the BS criteria, “Cognitive Disturbances” (COGDIS) and “Cognitive-perceptive BS” (COPER), were assessed with the “Schizophrenia Proneness Instrument, Adult version” (SPI-A). Using logistic regressions, prevalence rates of perceptive and cognitive BS, and of COGDIS and COPER, as well as the impact of social and role functioning on the association between age and BS were studied in three age groups (15–18 years, 19–23 years, 24–40 years). Most patients (91.2%) reported any BS, 55.9% any perceptive and 87.4% any cognitive BS. Furthermore, 56.3% met COGDIS and 80.5% COPER. Not exhibiting the reported differential age thresholds, both perceptive and cognitive BS, and, at trend level only, COPER were less prevalent in the oldest age group (24–40 years); COGDIS was most frequent in the youngest group (15–18 years). Functional deficits did not better explain the association with age, particularly in perceptive BS and cognitive BS meeting the frequency requirement of BS criteria. Our findings broadly confirmed an age threshold in BS and, thus, the earlier assumed link between presence of BS and brain maturation processes. Yet, age thresholds of perceptive and cognitive BS did not differ. This lack of differential age thresholds might be due to more pronounced the brain abnormalities in this clinical sample compared to earlier community samples. These might have also shown in more frequently occurring and persistent BS that, however, also resulted from a sampling toward these, i.e., toward COGDIS. Future studies should address the neurobiological basis of CHR criteria in relation to age.https://www.frontiersin.org/articles/10.3389/fpsyt.2020.552175/fullpsychosisclinical high riskbasic symptomsagebrain maturation |
| spellingShingle | Helene Walger Linda A. Antonucci Alessandro Pigoni Alessandro Pigoni Rachel Upthegrove Raimo K. R. Salokangas Rebekka Lencer Katharine Chisholm Katharine Chisholm Anita Riecher-Rössler Theresa Haidl Eva Meisenzahl Marlene Rosen Stephan Ruhrmann Joseph Kambeitz Lana Kambeitz-Ilankovic Peter Falkai Anne Ruef Jarmo Hietala Christos Pantelis Stephen J. Wood Stephen J. Wood Stephen J. Wood Paolo Brambilla Alessandro Bertolino Stefan Borgwardt Nikolaos Koutsouleris Frauke Schultze-Lutter Frauke Schultze-Lutter Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study Frontiers in Psychiatry psychosis clinical high risk basic symptoms age brain maturation |
| title | Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study |
| title_full | Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study |
| title_fullStr | Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study |
| title_full_unstemmed | Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study |
| title_short | Basic Symptoms Are Associated With Age in Patients With a Clinical High-Risk State for Psychosis: Results From the PRONIA Study |
| title_sort | basic symptoms are associated with age in patients with a clinical high risk state for psychosis results from the pronia study |
| topic | psychosis clinical high risk basic symptoms age brain maturation |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2020.552175/full |
| work_keys_str_mv | AT helenewalger basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT lindaaantonucci basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT alessandropigoni basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT alessandropigoni basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT rachelupthegrove basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT raimokrsalokangas basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT rebekkalencer basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT katharinechisholm basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT katharinechisholm basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT anitariecherrossler basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT theresahaidl basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT evameisenzahl basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT marlenerosen basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT stephanruhrmann basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT josephkambeitz basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT lanakambeitzilankovic basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT peterfalkai basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT anneruef basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT jarmohietala basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT christospantelis basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT stephenjwood basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT stephenjwood basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT stephenjwood basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT paolobrambilla basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT alessandrobertolino basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT stefanborgwardt basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT nikolaoskoutsouleris basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT fraukeschultzelutter basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy AT fraukeschultzelutter basicsymptomsareassociatedwithageinpatientswithaclinicalhighriskstateforpsychosisresultsfromtheproniastudy |