Phospholipid transfer protein activity in two cholestatic patients
CONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes...
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Format: | Article |
Language: | English |
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Associação Paulista de Medicina
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Series: | São Paulo Medical Journal |
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Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400009&lng=en&tlng=en |
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author | Eliana Cotta de Faria Adriana Celeste Gebrin Wilson Nadruz Júnior Lucia Nassi Castilho |
author_facet | Eliana Cotta de Faria Adriana Celeste Gebrin Wilson Nadruz Júnior Lucia Nassi Castilho |
author_sort | Eliana Cotta de Faria |
collection | DOAJ |
description | CONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes a net movement of phospholipids, thereby generating small lipid-poor apolipoprotein AI that contains particles and subfractions that are good acceptors for cell cholesterol efflux. CASE REPORT: We measured the activity of plasma phospholipid transfer protein in two cholestatic patients, assuming that changes in activity would occur in serum that was positive for lipoprotein X. Both patients presented severe hypercholesterolemia, high levels of low density lipoprotein cholesterol and, in one case, low levels of high density lipoprotein cholesterol and high levels of phospholipid serum. The phospholipid transfer activity was close to the lower limit of the reference interval. To our knowledge, this is the first time such results have been presented. We propose that phospholipid transfer protein activity becomes reduced under cholestasis conditions because of changes in the chemical composition of high density lipoproteins, such as an increase in phospholipids content. Also, lipoprotein X, which is rich in phospholipids, could compete with high density lipoproteins as a substrate for phospholipid transfer protein. |
first_indexed | 2024-12-12T21:00:02Z |
format | Article |
id | doaj.art-e00deecea90046d09404b079952f282a |
institution | Directory Open Access Journal |
issn | 1806-9460 |
language | English |
last_indexed | 2024-12-12T21:00:02Z |
publisher | Associação Paulista de Medicina |
record_format | Article |
series | São Paulo Medical Journal |
spelling | doaj.art-e00deecea90046d09404b079952f282a2022-12-22T00:12:10ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460122417517710.1590/S1516-31802004000400009S1516-31802004000400009Phospholipid transfer protein activity in two cholestatic patientsEliana Cotta de Faria0Adriana Celeste Gebrin1Wilson Nadruz Júnior2Lucia Nassi Castilho3Universidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasCONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes a net movement of phospholipids, thereby generating small lipid-poor apolipoprotein AI that contains particles and subfractions that are good acceptors for cell cholesterol efflux. CASE REPORT: We measured the activity of plasma phospholipid transfer protein in two cholestatic patients, assuming that changes in activity would occur in serum that was positive for lipoprotein X. Both patients presented severe hypercholesterolemia, high levels of low density lipoprotein cholesterol and, in one case, low levels of high density lipoprotein cholesterol and high levels of phospholipid serum. The phospholipid transfer activity was close to the lower limit of the reference interval. To our knowledge, this is the first time such results have been presented. We propose that phospholipid transfer protein activity becomes reduced under cholestasis conditions because of changes in the chemical composition of high density lipoproteins, such as an increase in phospholipids content. Also, lipoprotein X, which is rich in phospholipids, could compete with high density lipoproteins as a substrate for phospholipid transfer protein.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400009&lng=en&tlng=enCholestasisLipoprotein XPhospholipidsApolipoprotein A-IHypercholesterolemia |
spellingShingle | Eliana Cotta de Faria Adriana Celeste Gebrin Wilson Nadruz Júnior Lucia Nassi Castilho Phospholipid transfer protein activity in two cholestatic patients São Paulo Medical Journal Cholestasis Lipoprotein X Phospholipids Apolipoprotein A-I Hypercholesterolemia |
title | Phospholipid transfer protein activity in two cholestatic patients |
title_full | Phospholipid transfer protein activity in two cholestatic patients |
title_fullStr | Phospholipid transfer protein activity in two cholestatic patients |
title_full_unstemmed | Phospholipid transfer protein activity in two cholestatic patients |
title_short | Phospholipid transfer protein activity in two cholestatic patients |
title_sort | phospholipid transfer protein activity in two cholestatic patients |
topic | Cholestasis Lipoprotein X Phospholipids Apolipoprotein A-I Hypercholesterolemia |
url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400009&lng=en&tlng=en |
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