Phospholipid transfer protein activity in two cholestatic patients

CONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes...

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Main Authors: Eliana Cotta de Faria, Adriana Celeste Gebrin, Wilson Nadruz Júnior, Lucia Nassi Castilho
Format: Article
Language:English
Published: Associação Paulista de Medicina
Series:São Paulo Medical Journal
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400009&lng=en&tlng=en
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author Eliana Cotta de Faria
Adriana Celeste Gebrin
Wilson Nadruz Júnior
Lucia Nassi Castilho
author_facet Eliana Cotta de Faria
Adriana Celeste Gebrin
Wilson Nadruz Júnior
Lucia Nassi Castilho
author_sort Eliana Cotta de Faria
collection DOAJ
description CONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes a net movement of phospholipids, thereby generating small lipid-poor apolipoprotein AI that contains particles and subfractions that are good acceptors for cell cholesterol efflux. CASE REPORT: We measured the activity of plasma phospholipid transfer protein in two cholestatic patients, assuming that changes in activity would occur in serum that was positive for lipoprotein X. Both patients presented severe hypercholesterolemia, high levels of low density lipoprotein cholesterol and, in one case, low levels of high density lipoprotein cholesterol and high levels of phospholipid serum. The phospholipid transfer activity was close to the lower limit of the reference interval. To our knowledge, this is the first time such results have been presented. We propose that phospholipid transfer protein activity becomes reduced under cholestasis conditions because of changes in the chemical composition of high density lipoproteins, such as an increase in phospholipids content. Also, lipoprotein X, which is rich in phospholipids, could compete with high density lipoproteins as a substrate for phospholipid transfer protein.
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spelling doaj.art-e00deecea90046d09404b079952f282a2022-12-22T00:12:10ZengAssociação Paulista de MedicinaSão Paulo Medical Journal1806-9460122417517710.1590/S1516-31802004000400009S1516-31802004000400009Phospholipid transfer protein activity in two cholestatic patientsEliana Cotta de Faria0Adriana Celeste Gebrin1Wilson Nadruz Júnior2Lucia Nassi Castilho3Universidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasUniversidade Estadual de CampinasCONTEXT: Plasma phospholipid transfer protein mediates the transfer of phospholipids from triglyceride-rich lipoproteins, very low density lipoproteins and low density lipoproteins to high density lipoproteins, a process that is also efficient between high density lipoprotein particles. It promotes a net movement of phospholipids, thereby generating small lipid-poor apolipoprotein AI that contains particles and subfractions that are good acceptors for cell cholesterol efflux. CASE REPORT: We measured the activity of plasma phospholipid transfer protein in two cholestatic patients, assuming that changes in activity would occur in serum that was positive for lipoprotein X. Both patients presented severe hypercholesterolemia, high levels of low density lipoprotein cholesterol and, in one case, low levels of high density lipoprotein cholesterol and high levels of phospholipid serum. The phospholipid transfer activity was close to the lower limit of the reference interval. To our knowledge, this is the first time such results have been presented. We propose that phospholipid transfer protein activity becomes reduced under cholestasis conditions because of changes in the chemical composition of high density lipoproteins, such as an increase in phospholipids content. Also, lipoprotein X, which is rich in phospholipids, could compete with high density lipoproteins as a substrate for phospholipid transfer protein.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400009&lng=en&tlng=enCholestasisLipoprotein XPhospholipidsApolipoprotein A-IHypercholesterolemia
spellingShingle Eliana Cotta de Faria
Adriana Celeste Gebrin
Wilson Nadruz Júnior
Lucia Nassi Castilho
Phospholipid transfer protein activity in two cholestatic patients
São Paulo Medical Journal
Cholestasis
Lipoprotein X
Phospholipids
Apolipoprotein A-I
Hypercholesterolemia
title Phospholipid transfer protein activity in two cholestatic patients
title_full Phospholipid transfer protein activity in two cholestatic patients
title_fullStr Phospholipid transfer protein activity in two cholestatic patients
title_full_unstemmed Phospholipid transfer protein activity in two cholestatic patients
title_short Phospholipid transfer protein activity in two cholestatic patients
title_sort phospholipid transfer protein activity in two cholestatic patients
topic Cholestasis
Lipoprotein X
Phospholipids
Apolipoprotein A-I
Hypercholesterolemia
url http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-31802004000400009&lng=en&tlng=en
work_keys_str_mv AT elianacottadefaria phospholipidtransferproteinactivityintwocholestaticpatients
AT adrianacelestegebrin phospholipidtransferproteinactivityintwocholestaticpatients
AT wilsonnadruzjunior phospholipidtransferproteinactivityintwocholestaticpatients
AT lucianassicastilho phospholipidtransferproteinactivityintwocholestaticpatients