The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder
Abstract Background Despite widespread acknowledgment of the impact of stressful life events on suicide risk, the understanding of the psychological mechanisms underlying the relationship between stressful life events and suicide risk in major depressive disorder (MDD) remain unclear. This study aim...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-04600-7 |
| _version_ | 1797863908762976256 |
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| author | Jing Zhong Xiao-Jie Huang Xue-Mei Wang Ming-Zhi Xu |
| author_facet | Jing Zhong Xiao-Jie Huang Xue-Mei Wang Ming-Zhi Xu |
| author_sort | Jing Zhong |
| collection | DOAJ |
| description | Abstract Background Despite widespread acknowledgment of the impact of stressful life events on suicide risk, the understanding of the psychological mechanisms underlying the relationship between stressful life events and suicide risk in major depressive disorder (MDD) remain unclear. This study aim to examine whether the distress tolerance mediates the relationship between the stressful life events and suicide risk in patients with MDD. Methods A cross-sectional study was carried out among 125 Chinese patients with MDD, mean age was 27.05 (SD=0.68) and 68.8% were females. The 17-item Hamilton Depression Rating scale (HAMD-17), the validated Chinese version of the Mini International Neuropsychiatric Interview (MINI) suicide module, Life Events Scale (LES) and Distress Tolerance Scale (DTS) were utilized to evaluate depressive symptoms, stressful life events, levels of distress tolerance, and suicide risk, respectively. Mediation analyses was used to test the mediation effect of distress tolerance on the relationship between stressful life events and suicide risk. Results The ratio of suicide risk in patients with MDD was 75.2%. Pearson correlation analysis showed that stressful life events were positively correlated with suicide risk(r=0.182, p<0.05). Stressful life events(r=-0.323, p<0.01) and suicide risk(r=-0.354, p<0.01) were negatively correlated with distress tolerance. Mediation analyses showed that the direct path from stressful life events to suicide risk was not significant (B= 0.012, 95% confidence interval (CI) [-0.017, 0.042]). Stressful life events affected suicide risk indirectly through distress tolerance (B= 0.018, 95% CI [0.007, 0.031]), and the mediating effect accounted for 60.0% of the total effect. Conclusion Distress tolerance completely played a mediating role between stressful life events and suicide risk. Further suicide prevention and intervention strategies should focus on increasing levels of distress tolerance in patients with MDD. |
| first_indexed | 2024-04-09T22:44:16Z |
| format | Article |
| id | doaj.art-e00f4f3a6abd47419fbf333efbee4ff4 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-09T22:44:16Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-e00f4f3a6abd47419fbf333efbee4ff42023-03-22T12:00:50ZengBMCBMC Psychiatry1471-244X2023-02-012311810.1186/s12888-023-04600-7The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorderJing Zhong0Xiao-Jie Huang1Xue-Mei Wang2Ming-Zhi Xu3School of Public Health, Southern Medical UniversityGuangdong Mental Health Center, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical UniversityGuangdong Provincial Hospital of Traditional Chinese Medicine, Guangdong Provincial Academy of Chinese Medical Sciences, and The Second Clinical College, Guangzhou University of Chinese MedicineSchool of Public Health, Southern Medical UniversityAbstract Background Despite widespread acknowledgment of the impact of stressful life events on suicide risk, the understanding of the psychological mechanisms underlying the relationship between stressful life events and suicide risk in major depressive disorder (MDD) remain unclear. This study aim to examine whether the distress tolerance mediates the relationship between the stressful life events and suicide risk in patients with MDD. Methods A cross-sectional study was carried out among 125 Chinese patients with MDD, mean age was 27.05 (SD=0.68) and 68.8% were females. The 17-item Hamilton Depression Rating scale (HAMD-17), the validated Chinese version of the Mini International Neuropsychiatric Interview (MINI) suicide module, Life Events Scale (LES) and Distress Tolerance Scale (DTS) were utilized to evaluate depressive symptoms, stressful life events, levels of distress tolerance, and suicide risk, respectively. Mediation analyses was used to test the mediation effect of distress tolerance on the relationship between stressful life events and suicide risk. Results The ratio of suicide risk in patients with MDD was 75.2%. Pearson correlation analysis showed that stressful life events were positively correlated with suicide risk(r=0.182, p<0.05). Stressful life events(r=-0.323, p<0.01) and suicide risk(r=-0.354, p<0.01) were negatively correlated with distress tolerance. Mediation analyses showed that the direct path from stressful life events to suicide risk was not significant (B= 0.012, 95% confidence interval (CI) [-0.017, 0.042]). Stressful life events affected suicide risk indirectly through distress tolerance (B= 0.018, 95% CI [0.007, 0.031]), and the mediating effect accounted for 60.0% of the total effect. Conclusion Distress tolerance completely played a mediating role between stressful life events and suicide risk. Further suicide prevention and intervention strategies should focus on increasing levels of distress tolerance in patients with MDD.https://doi.org/10.1186/s12888-023-04600-7Major depressive disorder (MDD)Suicide riskDistress toleranceStressful life eventsMediating effect |
| spellingShingle | Jing Zhong Xiao-Jie Huang Xue-Mei Wang Ming-Zhi Xu The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder BMC Psychiatry Major depressive disorder (MDD) Suicide risk Distress tolerance Stressful life events Mediating effect |
| title | The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder |
| title_full | The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder |
| title_fullStr | The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder |
| title_full_unstemmed | The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder |
| title_short | The mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder |
| title_sort | mediating effect of distress tolerance on the relationship between stressful life events and suicide risk in patients with major depressive disorder |
| topic | Major depressive disorder (MDD) Suicide risk Distress tolerance Stressful life events Mediating effect |
| url | https://doi.org/10.1186/s12888-023-04600-7 |
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