Reference Range of Kaolin-Activated Thromboelastography (TEG) Values in Healthy Pet Rabbits (<i>Oryctolagus cuniculus</i>)

Thromboelastography (TEG) is a viscoelastic technique that allows the examination of both cellular and plasma protein clotting factors. Thromboelastography helps to investigate the underlying coagulopathy and to monitor therapeutic modalities. Although viscoelastic techniques have been used in human...

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Bibliographic Details
Main Authors: Tiziana Bassan, Josep Pastor, Beatriz Agulla, Oriol Jornet, Jaume Martorell
Format: Article
Language:English
Published: MDPI AG 2023-07-01
Series:Animals
Subjects:
Online Access:https://www.mdpi.com/2076-2615/13/14/2389
Description
Summary:Thromboelastography (TEG) is a viscoelastic technique that allows the examination of both cellular and plasma protein clotting factors. Thromboelastography helps to investigate the underlying coagulopathy and to monitor therapeutic modalities. Although viscoelastic techniques have been used in human and veterinary medicine, reference ranges in pet rabbits are missing. The objective of this study is to establish the reference-range values of TEG parameters in healthy pet rabbits. 24 healthy pet rabbits of different breeds were included: 16 crossbreeds, four Californians, two lops, one lionhead, and one angora. Four rabbits were less than one year old and 20 were older than one year. Twelve rabbits were neutered females, 10 neutered males, and two were intact females. Health status was assessed through a physical examination, a complete blood work, and a coagulation profile. A TEG 5000 Thromboelastograph Hemostasis System was used with kaolin-activated citrated whole blood. All samples were analysed 30 min postextraction. The TEG reference ranges were reaction time (R) 1.4–6.9 min; clot formation time (K) 0.8–2.2 min; α angle 65.8–82.2 degrees; maximal amplitude (MA) 53.7–73.5 mm; measure of clot strength/firmness (G-value) 5796.6–13,885.9 dyn/cm<sup>2</sup>; and percentage of clot lysis in 30 min (LY30%) 0–41.5%. This study provides the reference ranges of TEG in pet rabbits.
ISSN:2076-2615