Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly

Eic1 links Mis18 with the CCAN/Mis6/Ctf19 complex to promote CENP-A assembly

CENP-A chromatin forms the foundation for kinetochore assembly. Replication-independent incorporation of CENP-A at centromeres depends on its chaperone HJURPScm3, and Mis18 in vertebrates and fission yeast. The recruitment of Mis18 and HJURPScm3 to centromeres is cell cycle regulated. Vertebrate Mis...

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Bibliographic Details
Main Authors: Lakxmi Subramanian, Nicholas R. T. Toda, Juri Rappsilber, Robin C. Allshire
Format: Article
Language:English
Published: The Royal Society 2014-01-01
Series:Open Biology
Subjects:
cenp-a
centromeres
epigenetics
fission yeast
mis18
Online Access:https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.140043

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