Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients
Abstract Background Alopecia Areata (AA) is an acquired autoimmune form of non-scarring hair loss. Adiponectin and its gene polymorphism were related to many autoimmune disorders. Objective Assessment of adiponectin serum levels and adiponectin gene (ADIPOQ) (rs2241766) Single Nucleoid Polymorphis...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Dermatologia
2024-04-01
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| Series: | Anais Brasileiros de Dermatologia |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962024000200181&lng=en&tlng=en |
| _version_ | 1797205737336733696 |
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| author | Azza Gaber Antar Farag Eman Abd-Elfatah Badr Banan Mohamed Gamal Abd-Elaty Nada Farag Elnaidany Mai Medhat Mohamed Ghanem |
| author_facet | Azza Gaber Antar Farag Eman Abd-Elfatah Badr Banan Mohamed Gamal Abd-Elaty Nada Farag Elnaidany Mai Medhat Mohamed Ghanem |
| author_sort | Azza Gaber Antar Farag |
| collection | DOAJ |
| description | Abstract Background Alopecia Areata (AA) is an acquired autoimmune form of non-scarring hair loss. Adiponectin and its gene polymorphism were related to many autoimmune disorders. Objective Assessment of adiponectin serum levels and adiponectin gene (ADIPOQ) (rs2241766) Single Nucleoid Polymorphism (SNP) in AA patients and correlating the results with the disease severity in those patients. Methods This study included 75 AA patients and 75 age and gender-matched healthy subjects (controls). The severity of Alopecia Tool (SALT) score assessment to evaluate AA severity was done. Adiponectin serum levels by ELISA and ADIPOQ (rs2241766) SNP using PCR were performed. Results Adiponectin serum levels were significantly lower in AA patients than controls (p = 0.001). ADIPOQ (rs2241766) TG genotype and G allele were significantly predominant in AA patients increasing its risk by 5 and 4 folds (OR = 5.17, p = 0.001), (OR = 3.82, p = 0.001) respectively. Serum adiponectin levels were negatively correlated with SALT score (r = -0.435, p = 0.001) and associated with alopecia totalis (p = 0.016). ADIPOQ (rs2241766) TG genotype was significantly associated with low serum adiponectin levels and higher SALT score (p = 0.001). Study limitations The small sample size. Conclusions ADIPOQ (rs2241766) gene polymorphism (TG genotype and G allele) may modulate AA risk and contribute to the development of AA in Egyptian populations. Decreased circulating adiponectin levels may have a dynamic role in AA etiopathogenesis. Adiponectin serum concentration can be considered a severity marker of hair loss in AA. |
| first_indexed | 2024-04-24T08:55:52Z |
| format | Article |
| id | doaj.art-e012a98e0091456d98a5d7f16c079cda |
| institution | Directory Open Access Journal |
| issn | 0365-0596 |
| language | English |
| last_indexed | 2024-04-24T08:55:52Z |
| publishDate | 2024-04-01 |
| publisher | Sociedade Brasileira de Dermatologia |
| record_format | Article |
| series | Anais Brasileiros de Dermatologia |
| spelling | doaj.art-e012a98e0091456d98a5d7f16c079cda2024-04-16T07:41:48ZengSociedade Brasileira de DermatologiaAnais Brasileiros de Dermatologia0365-05962024-04-0199218118810.1016/j.abd.2023.05.003Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patientsAzza Gaber Antar Faraghttps://orcid.org/0000-0002-0333-5506Eman Abd-Elfatah Badrhttps://orcid.org/0000-0001-9724-1596Banan Mohamed Gamal Abd-Elatyhttps://orcid.org/0009-0007-3952-3625Nada Farag Elnaidanyhttps://orcid.org/0000-0003-3013-3720Mai Medhat Mohamed Ghanemhttps://orcid.org/0000-0002-3572-4653Abstract Background Alopecia Areata (AA) is an acquired autoimmune form of non-scarring hair loss. Adiponectin and its gene polymorphism were related to many autoimmune disorders. Objective Assessment of adiponectin serum levels and adiponectin gene (ADIPOQ) (rs2241766) Single Nucleoid Polymorphism (SNP) in AA patients and correlating the results with the disease severity in those patients. Methods This study included 75 AA patients and 75 age and gender-matched healthy subjects (controls). The severity of Alopecia Tool (SALT) score assessment to evaluate AA severity was done. Adiponectin serum levels by ELISA and ADIPOQ (rs2241766) SNP using PCR were performed. Results Adiponectin serum levels were significantly lower in AA patients than controls (p = 0.001). ADIPOQ (rs2241766) TG genotype and G allele were significantly predominant in AA patients increasing its risk by 5 and 4 folds (OR = 5.17, p = 0.001), (OR = 3.82, p = 0.001) respectively. Serum adiponectin levels were negatively correlated with SALT score (r = -0.435, p = 0.001) and associated with alopecia totalis (p = 0.016). ADIPOQ (rs2241766) TG genotype was significantly associated with low serum adiponectin levels and higher SALT score (p = 0.001). Study limitations The small sample size. Conclusions ADIPOQ (rs2241766) gene polymorphism (TG genotype and G allele) may modulate AA risk and contribute to the development of AA in Egyptian populations. Decreased circulating adiponectin levels may have a dynamic role in AA etiopathogenesis. Adiponectin serum concentration can be considered a severity marker of hair loss in AA.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962024000200181&lng=en&tlng=enAdiponectinAlopecia areataGenetics |
| spellingShingle | Azza Gaber Antar Farag Eman Abd-Elfatah Badr Banan Mohamed Gamal Abd-Elaty Nada Farag Elnaidany Mai Medhat Mohamed Ghanem Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients Anais Brasileiros de Dermatologia Adiponectin Alopecia areata Genetics |
| title | Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients |
| title_full | Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients |
| title_fullStr | Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients |
| title_full_unstemmed | Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients |
| title_short | Adiponectin serum levels and ADIPOQ (rs2241766) polymorphism in alopecia areata Egyptian patients |
| title_sort | adiponectin serum levels and adipoq rs2241766 polymorphism in alopecia areata egyptian patients |
| topic | Adiponectin Alopecia areata Genetics |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0365-05962024000200181&lng=en&tlng=en |
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