Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test
Background: To establish the reference values of native T1 and extracellular volume (ECV) in patients without structural heart disease and had a negative adenosine stress 3T cardiac magnetic resonance. Methods: Short-axis T1 mapping images were acquired using a modified Look-Locker inversion recover...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-04-01
|
| Series: | International Journal of Cardiology: Heart & Vasculature |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S235290672300012X |
| _version_ | 1797854563532800000 |
|---|---|
| author | Weerapat Kositanurit Nonthikorn Theerasuwipakorn Yongkasem Vorasettakarnkij Kanokvalee Ponkanist Chonthicha Lerdkhonsan Monravee Tumkosit David C. Wendell Pairoj Chattranukulchai |
| author_facet | Weerapat Kositanurit Nonthikorn Theerasuwipakorn Yongkasem Vorasettakarnkij Kanokvalee Ponkanist Chonthicha Lerdkhonsan Monravee Tumkosit David C. Wendell Pairoj Chattranukulchai |
| author_sort | Weerapat Kositanurit |
| collection | DOAJ |
| description | Background: To establish the reference values of native T1 and extracellular volume (ECV) in patients without structural heart disease and had a negative adenosine stress 3T cardiac magnetic resonance. Methods: Short-axis T1 mapping images were acquired using a modified Look-Locker inversion recovery technique before and after administration of 0.15 mmol/kg gadobutrol to calculate both native T1 and ECV. To compare the agreement between measurement strategies, regions of interest (ROI) were drawn in all 16 segments then averaged to represent mean global native T1. Additionally, an ROI was drawn in the mid-ventricular septum on the same image to represent the mid-ventricular septal native T1. Results: Fifty-one patients (mean 65 years, 65 % women) were included. Mean global native T1 averaged from all 16 segments and a mid-ventricular septal native T1 were not significantly different (1221.2 ± 35.2 vs 1228.4 ± 43.7 ms, p = 0.21). Men had lower mean global native T1 (1195 ± 29.8 vs 1235.5 ± 29.4 ms, p < 0.001) than women. Both mean global and mid-ventricular septal native T1 were not correlated with age (r = 0.21, p = 0.13 and r = 0.18, p = 0.19, respectively). The calculated ECV was 26.6 ± 2.7 %, which was not influenced by either gender or age. Conclusions: We report the first study to validate the native T1 and ECV reference ranges, factors influencing T1, and the validation across measurement methods in older Asian patients without structural heart disease and had a negative adenosine stress test. These references allow for better detection of abnormal myocardial tissue characteristics in clinical practice. |
| first_indexed | 2024-04-09T20:08:07Z |
| format | Article |
| id | doaj.art-e0154ed058994c0f9f660eb4c434ea6c |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-04-09T20:08:07Z |
| publishDate | 2023-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-e0154ed058994c0f9f660eb4c434ea6c2023-04-01T08:50:21ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672023-04-0145101181Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress testWeerapat Kositanurit0Nonthikorn Theerasuwipakorn1Yongkasem Vorasettakarnkij2Kanokvalee Ponkanist3Chonthicha Lerdkhonsan4Monravee Tumkosit5David C. Wendell6Pairoj Chattranukulchai7Department of Physiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, ThailandDivision of Cardiovascular Medicine, Faculty of Medicine, Chulalongkorn University, Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, ThailandDivision of Hospital and Ambulatory Medicine, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, ThailandDepartment of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, ThailandDepartment of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, ThailandDepartment of Radiology, Faculty of Medicine, Chulalongkorn University, King Chulalongkorn Memorial Hospital, Bangkok 10330, ThailandDuke Cardiovascular Magnetic Resonance Center, Division of Cardiology, Duke University Medical Center, Durham, NC 27708, USADivision of Cardiovascular Medicine, Faculty of Medicine, Chulalongkorn University, Cardiac Center, King Chulalongkorn Memorial Hospital, Bangkok 10330, Thailand; Corresponding author at: Division of Cardiovascular Medicine, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Cardiac Center, King Chulalongkorn Memorial Hospital, 1873 Rama IV Road, Pathumwan, Bangkok 10330, Thailand.Background: To establish the reference values of native T1 and extracellular volume (ECV) in patients without structural heart disease and had a negative adenosine stress 3T cardiac magnetic resonance. Methods: Short-axis T1 mapping images were acquired using a modified Look-Locker inversion recovery technique before and after administration of 0.15 mmol/kg gadobutrol to calculate both native T1 and ECV. To compare the agreement between measurement strategies, regions of interest (ROI) were drawn in all 16 segments then averaged to represent mean global native T1. Additionally, an ROI was drawn in the mid-ventricular septum on the same image to represent the mid-ventricular septal native T1. Results: Fifty-one patients (mean 65 years, 65 % women) were included. Mean global native T1 averaged from all 16 segments and a mid-ventricular septal native T1 were not significantly different (1221.2 ± 35.2 vs 1228.4 ± 43.7 ms, p = 0.21). Men had lower mean global native T1 (1195 ± 29.8 vs 1235.5 ± 29.4 ms, p < 0.001) than women. Both mean global and mid-ventricular septal native T1 were not correlated with age (r = 0.21, p = 0.13 and r = 0.18, p = 0.19, respectively). The calculated ECV was 26.6 ± 2.7 %, which was not influenced by either gender or age. Conclusions: We report the first study to validate the native T1 and ECV reference ranges, factors influencing T1, and the validation across measurement methods in older Asian patients without structural heart disease and had a negative adenosine stress test. These references allow for better detection of abnormal myocardial tissue characteristics in clinical practice.http://www.sciencedirect.com/science/article/pii/S235290672300012XNative T1 mappingExtracellular volume3 TeslaCardiac magnetic resonance |
| spellingShingle | Weerapat Kositanurit Nonthikorn Theerasuwipakorn Yongkasem Vorasettakarnkij Kanokvalee Ponkanist Chonthicha Lerdkhonsan Monravee Tumkosit David C. Wendell Pairoj Chattranukulchai Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test International Journal of Cardiology: Heart & Vasculature Native T1 mapping Extracellular volume 3 Tesla Cardiac magnetic resonance |
| title | Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test |
| title_full | Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test |
| title_fullStr | Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test |
| title_full_unstemmed | Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test |
| title_short | Reference values of myocardial native T1 and extracellular volume in patients without structural heart disease and had negative 3T cardiac magnetic resonance adenosine stress test |
| title_sort | reference values of myocardial native t1 and extracellular volume in patients without structural heart disease and had negative 3t cardiac magnetic resonance adenosine stress test |
| topic | Native T1 mapping Extracellular volume 3 Tesla Cardiac magnetic resonance |
| url | http://www.sciencedirect.com/science/article/pii/S235290672300012X |
| work_keys_str_mv | AT weerapatkositanurit referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT nonthikorntheerasuwipakorn referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT yongkasemvorasettakarnkij referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT kanokvaleeponkanist referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT chonthichalerdkhonsan referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT monraveetumkosit referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT davidcwendell referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest AT pairojchattranukulchai referencevaluesofmyocardialnativet1andextracellularvolumeinpatientswithoutstructuralheartdiseaseandhadnegative3tcardiacmagneticresonanceadenosinestresstest |