The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling?
It has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-07-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00097/full |
| _version_ | 1811298687370919936 |
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| author | Joe eXie Anna Pearl Shapiro Joseph Isaac Shapiro |
| author_facet | Joe eXie Anna Pearl Shapiro Joseph Isaac Shapiro |
| author_sort | Joe eXie |
| collection | DOAJ |
| description | It has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and tissue concentrations have been made. More recently, it has been identified that CTS also mediate signal transduction through the Na/K-ATPase, and consequently been implicated in profibrotic pathways. This review will discuss the mechanism of CTS in renal sodium handling and a potential trade-off effect from their role in inducing tissue fibrosis. |
| first_indexed | 2024-04-13T06:23:04Z |
| format | Article |
| id | doaj.art-e015d926e5af4bd69c0fa7a71e149cf0 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-13T06:23:04Z |
| publishDate | 2014-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e015d926e5af4bd69c0fa7a71e149cf02022-12-22T02:58:34ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922014-07-01510.3389/fendo.2014.0009796208The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling?Joe eXie0Anna Pearl Shapiro1Joseph Isaac Shapiro2University of ColoradoUniversity of ToledoMarshall UniversityIt has been postulated for some time that endogenous digitalis-like substances, also called cardiotonic steroids (CTS), exist, and that these substances are involved in sodium handling. Within the past 20 years, these substances have been unequivocally identified and measurements of circulating and tissue concentrations have been made. More recently, it has been identified that CTS also mediate signal transduction through the Na/K-ATPase, and consequently been implicated in profibrotic pathways. This review will discuss the mechanism of CTS in renal sodium handling and a potential trade-off effect from their role in inducing tissue fibrosis.http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00097/fullFibrosisHypertensionsignalingrenal failuresodium pumpCardiotonic steroids |
| spellingShingle | Joe eXie Anna Pearl Shapiro Joseph Isaac Shapiro The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling? Frontiers in Endocrinology Fibrosis Hypertension signaling renal failure sodium pump Cardiotonic steroids |
| title | The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling? |
| title_full | The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling? |
| title_fullStr | The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling? |
| title_full_unstemmed | The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling? |
| title_short | The Trade-off Between Dietary Salt and Cardiovascular Disease; a role for Na/K-ATPase signaling? |
| title_sort | trade off between dietary salt and cardiovascular disease a role for na k atpase signaling |
| topic | Fibrosis Hypertension signaling renal failure sodium pump Cardiotonic steroids |
| url | http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00097/full |
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