Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2
The production of specific neutralizing antibodies by individuals is thought to be the best option for reducing the number of patients with severe COVID-19, which is the reason why multiple vaccines are currently being administered worldwide. We aimed to explore the effect of revaccination with BCG,...
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MDPI AG
2021-11-01
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| author | Espiridión Ramos-Martinez Ramcés Falfán-Valencia Gloria Pérez-Rubio Warrison Athanasio Andrade Jorge Rojas-Serrano Enrique Ambrocio-Ortiz Dennisse S. Galicia-Álvarez Isaac Bárcenas-Montiel Andrea Velasco-Medina Guillermo Velázquez-Sámano |
| author_facet | Espiridión Ramos-Martinez Ramcés Falfán-Valencia Gloria Pérez-Rubio Warrison Athanasio Andrade Jorge Rojas-Serrano Enrique Ambrocio-Ortiz Dennisse S. Galicia-Álvarez Isaac Bárcenas-Montiel Andrea Velasco-Medina Guillermo Velázquez-Sámano |
| author_sort | Espiridión Ramos-Martinez |
| collection | DOAJ |
| description | The production of specific neutralizing antibodies by individuals is thought to be the best option for reducing the number of patients with severe COVID-19, which is the reason why multiple vaccines are currently being administered worldwide. We aimed to explore the effect of revaccination with BCG, on the response to a subsequent anti-SARS-CoV-2 vaccine, in persons occupationally exposed to COVID-19 patients. Two groups of 30 randomized participants were selected: one group received a BCG revaccination, and the other group received a placebo. Subsequently, both groups were vaccinated against SARS-CoV-2. After each round of vaccination, the serum concentration of Th1/Th2 cytokines was determined. At the end of the protocol, neutralizing antibodies were determined and the HLA-DRB loci were genotyped. The participants from the BCG group and anti-SARS-CoV-2 vaccine group had increased serum cytokine concentrations (i.e., IL-1β, IL-4, IL-6, IL-12p70, IL-13, IL-18, GM-CSF, INF-γ, and TNF-α) and higher neutralizing antibody titers, compared to the group with Placebo–anti-SARS-CoV-2. Twelve HLA-DRB1 alleles were identified in the Placebo–anti-SARS-CoV-2 group, and only nine in the group revaccinated with BCG. The DRB1*04 allele exhibited increased frequency in the Placebo–anti-SARS-CoV-2 group; however, no confounding effects were found with this allele. We conclude that revaccination with BCG synergizes with subsequent vaccination against SARS-CoV-2 in occupationally exposed personnel. |
| first_indexed | 2024-03-10T05:36:49Z |
| format | Article |
| id | doaj.art-e0180518a2dc4017a7eec43451a048f3 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T05:36:49Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-e0180518a2dc4017a7eec43451a048f32023-11-22T22:52:28ZengMDPI AGCells2073-44092021-11-011011317910.3390/cells10113179Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2Espiridión Ramos-Martinez0Ramcés Falfán-Valencia1Gloria Pérez-Rubio2Warrison Athanasio Andrade3Jorge Rojas-Serrano4Enrique Ambrocio-Ortiz5Dennisse S. Galicia-Álvarez6Isaac Bárcenas-Montiel7Andrea Velasco-Medina8Guillermo Velázquez-Sámano9Unidad de Investigación en Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Ciudad de México 06720, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoDepartamento de Biologia Celular e Molecular e Bioagentes Patogênicos, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14049-900, SP, BrazilUnidad de enfermedades del Intersticio Pulmonar y Reumatología, Instituto Nacional de Enfermedades Respiratorias, “Ismael Cosío Villegas”, Ciudad de México 14080, MexicoHLA Laboratory, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City 14080, MexicoServicio de Alergia e Inmunología Clínica, Hospital General de México, “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoServicio de Alergia e Inmunología Clínica, Hospital General de México, “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoServicio de Alergia e Inmunología Clínica, Hospital General de México, “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoServicio de Alergia e Inmunología Clínica, Hospital General de México, “Dr. Eduardo Liceaga”, Mexico City 06720, MexicoThe production of specific neutralizing antibodies by individuals is thought to be the best option for reducing the number of patients with severe COVID-19, which is the reason why multiple vaccines are currently being administered worldwide. We aimed to explore the effect of revaccination with BCG, on the response to a subsequent anti-SARS-CoV-2 vaccine, in persons occupationally exposed to COVID-19 patients. Two groups of 30 randomized participants were selected: one group received a BCG revaccination, and the other group received a placebo. Subsequently, both groups were vaccinated against SARS-CoV-2. After each round of vaccination, the serum concentration of Th1/Th2 cytokines was determined. At the end of the protocol, neutralizing antibodies were determined and the HLA-DRB loci were genotyped. The participants from the BCG group and anti-SARS-CoV-2 vaccine group had increased serum cytokine concentrations (i.e., IL-1β, IL-4, IL-6, IL-12p70, IL-13, IL-18, GM-CSF, INF-γ, and TNF-α) and higher neutralizing antibody titers, compared to the group with Placebo–anti-SARS-CoV-2. Twelve HLA-DRB1 alleles were identified in the Placebo–anti-SARS-CoV-2 group, and only nine in the group revaccinated with BCG. The DRB1*04 allele exhibited increased frequency in the Placebo–anti-SARS-CoV-2 group; however, no confounding effects were found with this allele. We conclude that revaccination with BCG synergizes with subsequent vaccination against SARS-CoV-2 in occupationally exposed personnel.https://www.mdpi.com/2073-4409/10/11/3179SARS-CoV-2COVID-19BCGvaccinationneutralizing antibodies |
| spellingShingle | Espiridión Ramos-Martinez Ramcés Falfán-Valencia Gloria Pérez-Rubio Warrison Athanasio Andrade Jorge Rojas-Serrano Enrique Ambrocio-Ortiz Dennisse S. Galicia-Álvarez Isaac Bárcenas-Montiel Andrea Velasco-Medina Guillermo Velázquez-Sámano Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2 Cells SARS-CoV-2 COVID-19 BCG vaccination neutralizing antibodies |
| title | Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2 |
| title_full | Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2 |
| title_fullStr | Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2 |
| title_full_unstemmed | Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2 |
| title_short | Effect of BCG Revaccination on Occupationally Exposed Medical Personnel Vaccinated against SARS-CoV-2 |
| title_sort | effect of bcg revaccination on occupationally exposed medical personnel vaccinated against sars cov 2 |
| topic | SARS-CoV-2 COVID-19 BCG vaccination neutralizing antibodies |
| url | https://www.mdpi.com/2073-4409/10/11/3179 |
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