Bioactive Metabolites from Terrestrial and Marine Actinomycetes
Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities. In this review, we delve into the life cycle, ecolo...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-08-01
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| Series: | Molecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1420-3049/28/15/5915 |
| _version_ | 1827731033682870272 |
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| author | Chananan Ngamcharungchit Nutsuda Chaimusik Watanalai Panbangred Jirayut Euanorasetr Bungonsiri Intra |
| author_facet | Chananan Ngamcharungchit Nutsuda Chaimusik Watanalai Panbangred Jirayut Euanorasetr Bungonsiri Intra |
| author_sort | Chananan Ngamcharungchit |
| collection | DOAJ |
| description | Actinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, and classification of actinomycetes, as well as their varied bioactive metabolites recently discovered between 2015 and 2023. Additionally, we explore promising strategies to unveil and investigate new bioactive metabolites, encompassing genome mining, activation of silent genes through signal molecules, and co-cultivation approaches. By presenting this comprehensive and up-to-date review, we hope to offer a potential solution to uncover novel bioactive compounds with essential activities. |
| first_indexed | 2024-03-11T00:20:59Z |
| format | Article |
| id | doaj.art-e01943e4c874408e9f3acb3a36116f61 |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-11T00:20:59Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-e01943e4c874408e9f3acb3a36116f612023-11-18T23:20:34ZengMDPI AGMolecules1420-30492023-08-012815591510.3390/molecules28155915Bioactive Metabolites from Terrestrial and Marine ActinomycetesChananan Ngamcharungchit0Nutsuda Chaimusik1Watanalai Panbangred2Jirayut Euanorasetr3Bungonsiri Intra4Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandResearch, Innovation and Partnerships Office, King Mongkut’s University of Technology Thonburi, Bangkok 10140, ThailandDepartment of Microbiology, Faculty of Science, King Mongkut’s University of Technology Thonburi, Bangkok 10140, ThailandDepartment of Biotechnology, Faculty of Science, Mahidol University, Bangkok 10400, ThailandActinomycetes inhabit both terrestrial and marine ecosystems and are highly proficient in producing a wide range of natural products with diverse biological functions, including antitumor, immunosuppressive, antimicrobial, and antiviral activities. In this review, we delve into the life cycle, ecology, taxonomy, and classification of actinomycetes, as well as their varied bioactive metabolites recently discovered between 2015 and 2023. Additionally, we explore promising strategies to unveil and investigate new bioactive metabolites, encompassing genome mining, activation of silent genes through signal molecules, and co-cultivation approaches. By presenting this comprehensive and up-to-date review, we hope to offer a potential solution to uncover novel bioactive compounds with essential activities.https://www.mdpi.com/1420-3049/28/15/5915actinomycetesbioactive metabolitesbiodiversitygenome miningsilent gene activation |
| spellingShingle | Chananan Ngamcharungchit Nutsuda Chaimusik Watanalai Panbangred Jirayut Euanorasetr Bungonsiri Intra Bioactive Metabolites from Terrestrial and Marine Actinomycetes Molecules actinomycetes bioactive metabolites biodiversity genome mining silent gene activation |
| title | Bioactive Metabolites from Terrestrial and Marine Actinomycetes |
| title_full | Bioactive Metabolites from Terrestrial and Marine Actinomycetes |
| title_fullStr | Bioactive Metabolites from Terrestrial and Marine Actinomycetes |
| title_full_unstemmed | Bioactive Metabolites from Terrestrial and Marine Actinomycetes |
| title_short | Bioactive Metabolites from Terrestrial and Marine Actinomycetes |
| title_sort | bioactive metabolites from terrestrial and marine actinomycetes |
| topic | actinomycetes bioactive metabolites biodiversity genome mining silent gene activation |
| url | https://www.mdpi.com/1420-3049/28/15/5915 |
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