Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis
Objective:. This study aimed to compare operative time, blood loss, and transfusion requirement in patients receiving a high tranexamic acid (TXA) dose of greater than 10 mg/kg versus those receiving a low dose of 10 mg/kg or less. Methods:. PubMed, Cochrane Central, and Embase were queried to perfo...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer
2022-10-01
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| Series: | Plastic and Reconstructive Surgery, Global Open |
| Online Access: | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004526 |
| _version_ | 1817978655044796416 |
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| author | Devon B. O’Donnell, BS Sima Vazquez, MS Jacob D. Greisman, BA Anaz Uddin, MS Gillian Graifman, BS Jose F. Dominguez, MD Elizabeth Zellner, MD Carrie R. Muh, MD |
| author_facet | Devon B. O’Donnell, BS Sima Vazquez, MS Jacob D. Greisman, BA Anaz Uddin, MS Gillian Graifman, BS Jose F. Dominguez, MD Elizabeth Zellner, MD Carrie R. Muh, MD |
| author_sort | Devon B. O’Donnell, BS |
| collection | DOAJ |
| description | Objective:. This study aimed to compare operative time, blood loss, and transfusion requirement in patients receiving a high tranexamic acid (TXA) dose of greater than 10 mg/kg versus those receiving a low dose of 10 mg/kg or less.
Methods:. PubMed, Cochrane Central, and Embase were queried to perform a systematic review with meta-analysis. Studies reporting outcomes of TXA use in craniosynostosis surgery were included. TXA dosing, operative time, blood loss, and transfusion requirement were the primary outcomes studied. Other variables studied included age and types of craniosynostosis.
Results:. In total, 398 individuals in the included articles received TXA for craniosynostosis surgery. TXA loading doses ranged from 10 mg/kg to 50 mg/kg. Overall, administration of TXA was not associated with changes in operative time, but was associated with decreased blood loss and transfusion requirement on meta-analysis. Comparison of high dose TXA (>10 mg/kg) versus low dose (10 mg/kg or less) showed no statistical differences in changes in operative time, blood loss, or transfusion requirement.
Conclusions:. Overall, TXA reduced blood loss and transfusion requirement in patients undergoing surgery for craniosynostosis. There was no difference in outcomes between high dose and low dose regimens amongst those receiving TXA. Low dose TXA appears adequate to achieve clinical efficacy with a low adverse event rate. |
| first_indexed | 2024-04-13T22:32:53Z |
| format | Article |
| id | doaj.art-e01a668e20fb4db299899de0d85d11d4 |
| institution | Directory Open Access Journal |
| issn | 2169-7574 |
| language | English |
| last_indexed | 2024-04-13T22:32:53Z |
| publishDate | 2022-10-01 |
| publisher | Wolters Kluwer |
| record_format | Article |
| series | Plastic and Reconstructive Surgery, Global Open |
| spelling | doaj.art-e01a668e20fb4db299899de0d85d11d42022-12-22T02:26:53ZengWolters KluwerPlastic and Reconstructive Surgery, Global Open2169-75742022-10-011010e452610.1097/GOX.0000000000004526202210000-00029Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysisDevon B. O’Donnell, BS0Sima Vazquez, MS1Jacob D. Greisman, BA2Anaz Uddin, MS3Gillian Graifman, BS4Jose F. Dominguez, MD5Elizabeth Zellner, MD6Carrie R. Muh, MD7From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.† Department of Surgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.From the * Department of Neurosurgery, Westchester Medical Center, New York Medical College, Valhalla, N.Y.Objective:. This study aimed to compare operative time, blood loss, and transfusion requirement in patients receiving a high tranexamic acid (TXA) dose of greater than 10 mg/kg versus those receiving a low dose of 10 mg/kg or less. Methods:. PubMed, Cochrane Central, and Embase were queried to perform a systematic review with meta-analysis. Studies reporting outcomes of TXA use in craniosynostosis surgery were included. TXA dosing, operative time, blood loss, and transfusion requirement were the primary outcomes studied. Other variables studied included age and types of craniosynostosis. Results:. In total, 398 individuals in the included articles received TXA for craniosynostosis surgery. TXA loading doses ranged from 10 mg/kg to 50 mg/kg. Overall, administration of TXA was not associated with changes in operative time, but was associated with decreased blood loss and transfusion requirement on meta-analysis. Comparison of high dose TXA (>10 mg/kg) versus low dose (10 mg/kg or less) showed no statistical differences in changes in operative time, blood loss, or transfusion requirement. Conclusions:. Overall, TXA reduced blood loss and transfusion requirement in patients undergoing surgery for craniosynostosis. There was no difference in outcomes between high dose and low dose regimens amongst those receiving TXA. Low dose TXA appears adequate to achieve clinical efficacy with a low adverse event rate.http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004526 |
| spellingShingle | Devon B. O’Donnell, BS Sima Vazquez, MS Jacob D. Greisman, BA Anaz Uddin, MS Gillian Graifman, BS Jose F. Dominguez, MD Elizabeth Zellner, MD Carrie R. Muh, MD Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis Plastic and Reconstructive Surgery, Global Open |
| title | Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis |
| title_full | Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis |
| title_fullStr | Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis |
| title_full_unstemmed | Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis |
| title_short | Tranexamic Acid Dosing in Craniosynostosis Surgery: A Systematic Review with Meta-analysis |
| title_sort | tranexamic acid dosing in craniosynostosis surgery a systematic review with meta analysis |
| url | http://journals.lww.com/prsgo/fulltext/10.1097/GOX.0000000000004526 |
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