Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology
Background: Dental implantology has witnessed substantial progress in recent years, driven by a growing emphasis on optimizing bone regeneration around dental implants. Nanoparticles have emerged as a potential tool for enhancing osseointegration and bone tissue regeneration. Materials and Methods:...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-01-01
|
| Series: | Journal of Pharmacy and Bioallied Sciences |
| Subjects: | |
| Online Access: | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2024;volume=16;issue=5;spage=847;epage=849;aulast=Sitamahalakshmi |
| _version_ | 1827293054725259264 |
|---|---|
| author | K Sitamahalakshmi Abhishek P George Skariah Reghunathan S Preethanath Samiksha Dubey Tazeen Dawood |
| author_facet | K Sitamahalakshmi Abhishek P George Skariah Reghunathan S Preethanath Samiksha Dubey Tazeen Dawood |
| author_sort | K Sitamahalakshmi |
| collection | DOAJ |
| description | Background: Dental implantology has witnessed substantial progress in recent years, driven by a growing emphasis on optimizing bone regeneration around dental implants. Nanoparticles have emerged as a potential tool for enhancing osseointegration and bone tissue regeneration. Materials and Methods: This human clinical trial enrolled 60 adult participants requiring dental implants. Patients were randomly assigned to one of two groups: a control group receiving conventional dental implants, and an experimental group receiving dental implants with nanoparticle-coated surfaces. Radiographic imaging, histological analysis of bone biopsies, and implant stability assessments were conducted at three and six months post-implantation. Results: Histological examination of bone biopsies revealed a statistically significant increase in new bone formation in the experimental group compared to the control group at both three and six months (P < 0.05). Radiographic assessment demonstrated a 25% higher bone density around nanoparticle-coated implants (P < 0.01) at the six-month mark. Implant stability quotient (ISQ) measurements indicated a 20% greater stability in the experimental group (P < 0.05) at the same time point. Conclusion: This human clinical trial provides strong evidence that the incorporation of nanoparticles on dental implant surfaces enhances bone regeneration and osseointegration in a human population. |
| first_indexed | 2024-04-24T13:18:42Z |
| format | Article |
| id | doaj.art-e01e73a1249d4578b497e04f8b32a5bb |
| institution | Directory Open Access Journal |
| issn | 0975-7406 |
| language | English |
| last_indexed | 2024-04-24T13:18:42Z |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pharmacy and Bioallied Sciences |
| spelling | doaj.art-e01e73a1249d4578b497e04f8b32a5bb2024-04-04T16:37:41ZengWolters Kluwer Medknow PublicationsJournal of Pharmacy and Bioallied Sciences0975-74062024-01-0116584784910.4103/jpbs.jpbs_1057_23Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantologyK SitamahalakshmiAbhishekP George SkariahReghunathan S PreethanathSamiksha DubeyTazeen DawoodBackground: Dental implantology has witnessed substantial progress in recent years, driven by a growing emphasis on optimizing bone regeneration around dental implants. Nanoparticles have emerged as a potential tool for enhancing osseointegration and bone tissue regeneration. Materials and Methods: This human clinical trial enrolled 60 adult participants requiring dental implants. Patients were randomly assigned to one of two groups: a control group receiving conventional dental implants, and an experimental group receiving dental implants with nanoparticle-coated surfaces. Radiographic imaging, histological analysis of bone biopsies, and implant stability assessments were conducted at three and six months post-implantation. Results: Histological examination of bone biopsies revealed a statistically significant increase in new bone formation in the experimental group compared to the control group at both three and six months (P < 0.05). Radiographic assessment demonstrated a 25% higher bone density around nanoparticle-coated implants (P < 0.01) at the six-month mark. Implant stability quotient (ISQ) measurements indicated a 20% greater stability in the experimental group (P < 0.05) at the same time point. Conclusion: This human clinical trial provides strong evidence that the incorporation of nanoparticles on dental implant surfaces enhances bone regeneration and osseointegration in a human population.http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2024;volume=16;issue=5;spage=847;epage=849;aulast=Sitamahalakshmibone regenerationclinical trialdental implantologydental implantshistologyimplant stabilitynanoparticlesosseointegrationradiography |
| spellingShingle | K Sitamahalakshmi Abhishek P George Skariah Reghunathan S Preethanath Samiksha Dubey Tazeen Dawood Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology Journal of Pharmacy and Bioallied Sciences bone regeneration clinical trial dental implantology dental implants histology implant stability nanoparticles osseointegration radiography |
| title | Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology |
| title_full | Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology |
| title_fullStr | Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology |
| title_full_unstemmed | Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology |
| title_short | Evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology |
| title_sort | evaluating the role of nanoparticles in enhancing bone regeneration in dental implantology |
| topic | bone regeneration clinical trial dental implantology dental implants histology implant stability nanoparticles osseointegration radiography |
| url | http://www.jpbsonline.org/article.asp?issn=0975-7406;year=2024;volume=16;issue=5;spage=847;epage=849;aulast=Sitamahalakshmi |
| work_keys_str_mv | AT ksitamahalakshmi evaluatingtheroleofnanoparticlesinenhancingboneregenerationindentalimplantology AT abhishek evaluatingtheroleofnanoparticlesinenhancingboneregenerationindentalimplantology AT pgeorgeskariah evaluatingtheroleofnanoparticlesinenhancingboneregenerationindentalimplantology AT reghunathanspreethanath evaluatingtheroleofnanoparticlesinenhancingboneregenerationindentalimplantology AT samikshadubey evaluatingtheroleofnanoparticlesinenhancingboneregenerationindentalimplantology AT tazeendawood evaluatingtheroleofnanoparticlesinenhancingboneregenerationindentalimplantology |