Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation

Progesterone Receptor B signaling Reduces Breast Cancer Cell Aggressiveness: Role of Cyclin-D1/Cdk4 Mediating Paxillin Phosphorylation

Progesterone-Receptor (PR) positivity is related with an enhanced response to breast cancer therapy, conversely cyclin D1 (CD1) is a retained marker of poor outcome. Herein, we demonstrate that hydroxyprogesterone (OHPg) through progesterone receptor B (PR-B) reduces breast cancer cell aggressivenes...

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Bibliographic Details
Main Authors: Francesca Ida Montalto, Francesca Giordano, Chiara Chiodo, Stefania Marsico, Loredana Mauro, Diego Sisci, Saveria Aquila, Marilena Lanzino, Maria Luisa Panno, Sebastiano Andò, Francesca De Amicis
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Cancers
Subjects:
invasion
EMT
luminal A
paxillin
Rho GTPase
Online Access:https://www.mdpi.com/2072-6694/11/8/1201

Internet

https://www.mdpi.com/2072-6694/11/8/1201

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