Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature
Abstract Background Peripheral manifestations secondary to progressive vascular occlusions are characteristic of the rare condition termed thromboangiitis obliternas (TAO) or Buerger’s disease. The central manifestations of this disease are however poorly characterized, particularly those of psychia...
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Journal of Medical Case Reports |
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| Online Access: | https://doi.org/10.1186/s13256-022-03694-z |
| _version_ | 1811171727241117696 |
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| author | Mahmoud A. Awara Laura M. Downing Manal O. Elnenaei |
| author_facet | Mahmoud A. Awara Laura M. Downing Manal O. Elnenaei |
| author_sort | Mahmoud A. Awara |
| collection | DOAJ |
| description | Abstract Background Peripheral manifestations secondary to progressive vascular occlusions are characteristic of the rare condition termed thromboangiitis obliternas (TAO) or Buerger’s disease. The central manifestations of this disease are however poorly characterized, particularly those of psychiatric nature, and their prevalence is largely unknown. Speculations have been made around the polymorphic nature and triggers of observed psychopathology in TAO; much however remains to be unraveled in this area. Case presentation We present the case of a 33-year-old Caucasian male who developed first episode of psychosis at the age of 29 years. There was no history of previous mental illness either in the patient, or in any of his family members. He had been a long- term heavy smoker and was experiencing progressive lower limb claudication since the age of 22 years; however, all inflammatory, autoimmune and atherosclerotic markers were negative. His psychosis was characterized by retention of a warm affect, and despite some amelioration, was generally resistant to a fair trial of several anti-psychotic medications including Clozapine. Conclusion The pathophysiology of psychosis secondary to Buerger’s is not yet well characterized which adds to the complexity of managing these cases. Recognizing that cerebral manifestations of this disease may evolve several years after the onset of peripheral thromboangiitic features is important for following the natural history and considering measures that may reduce the burden of illness. |
| first_indexed | 2024-04-10T17:18:49Z |
| format | Article |
| id | doaj.art-e01eedcd475c46d5b77134c65cb9386b |
| institution | Directory Open Access Journal |
| issn | 1752-1947 |
| language | English |
| last_indexed | 2024-04-10T17:18:49Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Medical Case Reports |
| spelling | doaj.art-e01eedcd475c46d5b77134c65cb9386b2023-02-05T12:14:02ZengBMCJournal of Medical Case Reports1752-19472023-01-011711810.1186/s13256-022-03694-zPsychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature Mahmoud A. Awara0Laura M. Downing1Manal O. Elnenaei2Department of Psychiatry, Dalhousie University, Medical SchoolDepartment of Psychiatry, Dalhousie University, Medical SchoolThe College of Physicians and Surgeons of Nova ScotiaAbstract Background Peripheral manifestations secondary to progressive vascular occlusions are characteristic of the rare condition termed thromboangiitis obliternas (TAO) or Buerger’s disease. The central manifestations of this disease are however poorly characterized, particularly those of psychiatric nature, and their prevalence is largely unknown. Speculations have been made around the polymorphic nature and triggers of observed psychopathology in TAO; much however remains to be unraveled in this area. Case presentation We present the case of a 33-year-old Caucasian male who developed first episode of psychosis at the age of 29 years. There was no history of previous mental illness either in the patient, or in any of his family members. He had been a long- term heavy smoker and was experiencing progressive lower limb claudication since the age of 22 years; however, all inflammatory, autoimmune and atherosclerotic markers were negative. His psychosis was characterized by retention of a warm affect, and despite some amelioration, was generally resistant to a fair trial of several anti-psychotic medications including Clozapine. Conclusion The pathophysiology of psychosis secondary to Buerger’s is not yet well characterized which adds to the complexity of managing these cases. Recognizing that cerebral manifestations of this disease may evolve several years after the onset of peripheral thromboangiitic features is important for following the natural history and considering measures that may reduce the burden of illness.https://doi.org/10.1186/s13256-022-03694-zTreatment resistant organic psychosisThromboangiitis obliterans inducing psychosisCase reportBuerger's disease and schizophrenia-like-psychosis |
| spellingShingle | Mahmoud A. Awara Laura M. Downing Manal O. Elnenaei Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature Journal of Medical Case Reports Treatment resistant organic psychosis Thromboangiitis obliterans inducing psychosis Case report Buerger's disease and schizophrenia-like-psychosis |
| title | Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature |
| title_full | Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature |
| title_fullStr | Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature |
| title_full_unstemmed | Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature |
| title_short | Psychiatric sequelae of thromboangiitis obliterans: a case report and review of the literature |
| title_sort | psychiatric sequelae of thromboangiitis obliterans a case report and review of the literature |
| topic | Treatment resistant organic psychosis Thromboangiitis obliterans inducing psychosis Case report Buerger's disease and schizophrenia-like-psychosis |
| url | https://doi.org/10.1186/s13256-022-03694-z |
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