TMEM16K is an interorganelle regulator of endosomal sorting
The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting.
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-17016-8 |
| _version_ | 1818856255700074496 |
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| author | Maja Petkovic Juan Oses-Prieto Alma Burlingame Lily Yeh Jan Yuh Nung Jan |
| author_facet | Maja Petkovic Juan Oses-Prieto Alma Burlingame Lily Yeh Jan Yuh Nung Jan |
| author_sort | Maja Petkovic |
| collection | DOAJ |
| description | The endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting. |
| first_indexed | 2024-12-19T08:21:36Z |
| format | Article |
| id | doaj.art-e026443ef1f54cb589f59433ef9e4058 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-19T08:21:36Z |
| publishDate | 2020-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e026443ef1f54cb589f59433ef9e40582022-12-21T20:29:23ZengNature PortfolioNature Communications2041-17232020-07-0111111610.1038/s41467-020-17016-8TMEM16K is an interorganelle regulator of endosomal sortingMaja Petkovic0Juan Oses-Prieto1Alma Burlingame2Lily Yeh Jan3Yuh Nung Jan4Departments of Physiology, Biochemistry and Biophysics, University of California at San FranciscoDepartment of Pharmaceutical Chemistry, University of California San FranciscoDepartment of Pharmaceutical Chemistry, University of California San FranciscoDepartments of Physiology, Biochemistry and Biophysics, University of California at San FranciscoDepartments of Physiology, Biochemistry and Biophysics, University of California at San FranciscoThe endolysosomal pathway plays an important role in regulating protein and lipid sorting and degradation. Here, the authors show that TMEM16K, an endoplasmic reticulum lipid scramblase, forms ER-endosome contact sites where it regulates endosomal sorting.https://doi.org/10.1038/s41467-020-17016-8 |
| spellingShingle | Maja Petkovic Juan Oses-Prieto Alma Burlingame Lily Yeh Jan Yuh Nung Jan TMEM16K is an interorganelle regulator of endosomal sorting Nature Communications |
| title | TMEM16K is an interorganelle regulator of endosomal sorting |
| title_full | TMEM16K is an interorganelle regulator of endosomal sorting |
| title_fullStr | TMEM16K is an interorganelle regulator of endosomal sorting |
| title_full_unstemmed | TMEM16K is an interorganelle regulator of endosomal sorting |
| title_short | TMEM16K is an interorganelle regulator of endosomal sorting |
| title_sort | tmem16k is an interorganelle regulator of endosomal sorting |
| url | https://doi.org/10.1038/s41467-020-17016-8 |
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