Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy
Yuanyuan Fan,1,* Nazeer Hussain Khan,1,* Muhammad Farhan Ali Khan,2 MD Faysal Ahammad,3 Tayyaba Zulfiqar,2 Razia Virk,4 Enshe Jiang5 1School of Life Sciences, Henan University, Kaifeng, Henan, 475004, People’s Republic of China; 2Department of Pharmacy, Quaid I Azam University, Islam...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2022-04-01
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| Series: | Cancer Management and Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-of-hypertension-and-breast-cancer-antihypertensive-drugs-a-peer-reviewed-fulltext-article-CMAR |
| _version_ | 1819157525941977088 |
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| author | Fan Y Khan NH Farhan Ali Khan M Ahammad MF Zulfiqar T Virk R Jiang E |
| author_facet | Fan Y Khan NH Farhan Ali Khan M Ahammad MF Zulfiqar T Virk R Jiang E |
| author_sort | Fan Y |
| collection | DOAJ |
| description | Yuanyuan Fan,1,* Nazeer Hussain Khan,1,* Muhammad Farhan Ali Khan,2 MD Faysal Ahammad,3 Tayyaba Zulfiqar,2 Razia Virk,4 Enshe Jiang5 1School of Life Sciences, Henan University, Kaifeng, Henan, 475004, People’s Republic of China; 2Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan; 3Key Laboratory of Natural Medicine and Immune Engineering, School of Medicine, Henan University, Kaifeng, People’s Republic of China; 4Department of Bio-Sciences, University Wah, Rawalpindi, Pakistan; 5Institute of Nursing and Health, Henan University, Kaifeng, 475004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Enshe Jiang, Email esjiang@gmail.comAbstract: Breast cancer (BC) is the most common malignancy affecting women, and its incidence in younger women is rising worldwide. Early-onset of BC is a multi-step process involving various biological aggressive tumors such as triple negative and human epidermal growth factor 2 (HER2)-positive cancers. BC prevention is still arduous across the globe. A series of observational studies have established a conclusive non-genetic clinical link between hypertension (HTN) and the development of invasive BC. Those clinical associations have driven a pharmacological seek to use the anti-hypertension (AHTN) drugs as an effective adjunctive in BC therapy. The use of AHTN, especially beta-blockers and thiazides, has been recognized as a potent anti-tumor drug to mitigate BC progression, reduce the side effects of cancer treatment, and stop the reoccurrence of cancer in the survivors. Considering the dire need to disseminate the research on how AHTN drugs can be opted as the effective adjunctive therapy to cure the BC, the current review aimed to provide an update on novel understandings on association and mechanisms of AHTN-drugs against BC as an additional cancer therapy.Keywords: breast cancer, beta blockers, hypertension, hypertensive drugs, thiazides |
| first_indexed | 2024-12-22T16:10:09Z |
| format | Article |
| id | doaj.art-e028836b319941f7b1e6ed68716cd157 |
| institution | Directory Open Access Journal |
| issn | 1179-1322 |
| language | English |
| last_indexed | 2024-12-22T16:10:09Z |
| publishDate | 2022-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Cancer Management and Research |
| spelling | doaj.art-e028836b319941f7b1e6ed68716cd1572022-12-21T18:20:30ZengDove Medical PressCancer Management and Research1179-13222022-04-01Volume 141323132974126Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer TherapyFan YKhan NHFarhan Ali Khan MAhammad MFZulfiqar TVirk RJiang EYuanyuan Fan,1,* Nazeer Hussain Khan,1,* Muhammad Farhan Ali Khan,2 MD Faysal Ahammad,3 Tayyaba Zulfiqar,2 Razia Virk,4 Enshe Jiang5 1School of Life Sciences, Henan University, Kaifeng, Henan, 475004, People’s Republic of China; 2Department of Pharmacy, Quaid I Azam University, Islamabad, Pakistan; 3Key Laboratory of Natural Medicine and Immune Engineering, School of Medicine, Henan University, Kaifeng, People’s Republic of China; 4Department of Bio-Sciences, University Wah, Rawalpindi, Pakistan; 5Institute of Nursing and Health, Henan University, Kaifeng, 475004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Enshe Jiang, Email esjiang@gmail.comAbstract: Breast cancer (BC) is the most common malignancy affecting women, and its incidence in younger women is rising worldwide. Early-onset of BC is a multi-step process involving various biological aggressive tumors such as triple negative and human epidermal growth factor 2 (HER2)-positive cancers. BC prevention is still arduous across the globe. A series of observational studies have established a conclusive non-genetic clinical link between hypertension (HTN) and the development of invasive BC. Those clinical associations have driven a pharmacological seek to use the anti-hypertension (AHTN) drugs as an effective adjunctive in BC therapy. The use of AHTN, especially beta-blockers and thiazides, has been recognized as a potent anti-tumor drug to mitigate BC progression, reduce the side effects of cancer treatment, and stop the reoccurrence of cancer in the survivors. Considering the dire need to disseminate the research on how AHTN drugs can be opted as the effective adjunctive therapy to cure the BC, the current review aimed to provide an update on novel understandings on association and mechanisms of AHTN-drugs against BC as an additional cancer therapy.Keywords: breast cancer, beta blockers, hypertension, hypertensive drugs, thiazideshttps://www.dovepress.com/association-of-hypertension-and-breast-cancer-antihypertensive-drugs-a-peer-reviewed-fulltext-article-CMARbreast cancerbeta blockershypertensionhypertensive drugsthiazides |
| spellingShingle | Fan Y Khan NH Farhan Ali Khan M Ahammad MF Zulfiqar T Virk R Jiang E Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy Cancer Management and Research breast cancer beta blockers hypertension hypertensive drugs thiazides |
| title | Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy |
| title_full | Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy |
| title_fullStr | Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy |
| title_full_unstemmed | Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy |
| title_short | Association of Hypertension and Breast Cancer: Antihypertensive Drugs as an Effective Adjunctive in Breast Cancer Therapy |
| title_sort | association of hypertension and breast cancer antihypertensive drugs as an effective adjunctive in breast cancer therapy |
| topic | breast cancer beta blockers hypertension hypertensive drugs thiazides |
| url | https://www.dovepress.com/association-of-hypertension-and-breast-cancer-antihypertensive-drugs-a-peer-reviewed-fulltext-article-CMAR |
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