Analysis of the Deleterious Single-Nucleotide Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder

Analysis of the Deleterious Single-Nucleotide Polymorphisms Associated With Antidepressant Efficacy in Major Depressive Disorder

Major depressive disorder (MDD) is a serious mental disease with negative effects on both mental and physical health of the patient. Currently, antidepressants are among the major ways to ease or treat MDD. However, the existing antidepressants have limited efficacy in treating MDD, with a large fra...

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Bibliographic Details
Main Authors: Juncai Xin, Meng Yuan, Yonglin Peng, Ju Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-03-01
Series:Frontiers in Psychiatry
Subjects:
major depressive disorder
antidepressants
non-synonymous SNPs
protein structure
molecular dynamics simulations
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2020.00151/full

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